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Linogliride

NMR下載 COA and HPLC MSDS下載
names：
(E)-N-((E)-1-methylpyrrolidin-2-ylidene)-N'-phenylmorpholine-4-carboximidamide
CAS號：
75358-37-1
MDL Number：
MF(分子式)： C16H22N4O MW(分子量)： 286.37
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文別名	Linogliride
英文別名	Linogliride; McN 3935; McN-3935; McN3935; Linogliridum; Linoglirida;
CAS號	75358-37-1
Inchi	InChI=1S/C16H22N4O/c1-19-9-5-8-15(19)18-16(20-10-12-21-13-11-20)17-14-6-3-2-4-7-14/h2-4,6-7H,5,8-13H2,1H3/b17-16-,18-15+
InchiKey	OPPLDIXFHYTSSR-YQFKSOGVSA-N
分子式 Formula	C16H22N4O
分子量 Molecular Weight	286.37
溶解度Solubility
性狀	Solid powder
儲藏條件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

產(chǎn)品說明	Linogliride(CAS:75358-37-1):僅限應用于工業(yè)或者科學研究過程中非醫(yī)療目的，不應用于人類或動物的臨床診斷以及治過程療，該產(chǎn)品非藥用，非食用。
Introduction	Linogliride is an antidiabetic agent.
Application1
Application2
Application3

警示圖
危險性	Warning
危險性警示
安全聲明
安全防護
備注

[1]Levin PA, Jovanovic L, Chalew SA, Martin L, Pitarra DK, Kim F, Kowarski AA. Linogliride fumarate, representing a new class of oral hypoglycemic agent for diabetes. Clin Pharmacol Ther. 1987 Nov;42(5):498-503. PubMed PMID: 3315390.

[2]Ronner P, Cheong E, Khalid P, Tuman RW, Matschinsky FM. Effect of linogliride on hormone release from perfused rat pancreas. Fuel dependence and desensitization by tolbutamide. Diabetes. 1991 Jul;40(7):878-84. PubMed PMID: 2060724.

[3] Ronner P, Higgins TJ, Kimmich GA. Inhibition of ATP-sensitive K+ channels in pancreatic beta-cells by nonsulfonylurea drug linogliride. Diabetes. 1991 Jul;40(7):885-92. PubMed PMID: 2060725.

[4] Zawalich WS, Rasmussen G, Tuman RW, Tutwiler GF. Influence of the oral hypoglycemic agent linogliride (McN-3935) on insulin secretion from isolated rat islets of Langerhans. Endocrinology. 1987 Mar;120(3):880-5. PubMed PMID: 3542516.

[5] Wu WN, Mutter MS. Biotransformation of linogliride, a hypoglycemic agent in laboratory animals and humans. J Pharm Biomed Anal. 1995 Jun;13(7):857-67. PubMed PMID: 8562609.

6: Salhanick AI, Leighty SJ, Amatruda JM. Postreceptor regulation of insulin action in primary cultures of rat hepatocytes by oral hypoglycemic agents: effects of linogliride and chlorpropamide. Horm Metab Res. 1989 Nov;21(11):596-601. PubMed PMID: 2687145.7: Ng KT, Holland ML, Plutte JA. Determination of linogliride in biological fluids by high-performance liquid chromatography. J Chromatogr. 1984 Nov 28;311(2):418-23. PubMed PMID: 6520190.8: Chrzanowski FA, Ahmad K. The preparation and evaluation of salt forms of linogliride with reduced solubilities as candidates for extended release. Drug Dev Ind Pharm. 2017 Mar;43(3):421-431. doi: 10.1080/03639045.2016.1257019. Epub 2016 Nov 21. PubMed PMID: 27808569.9: Woodfork KA, Wonderlin WF, Peterson VA, Strobl JS. Inhibition of ATP-sensitive potassium channels causes reversible cell-cycle arrest of human breast cancer cells in tissue culture. J Cell Physiol. 1995 Feb;162(2):163-71. PubMed PMID: 7822427.10: Klimatcheva E, Wonderlin WF. An ATP-sensitive K(+) current that regulates progression through early G1 phase of the cell cycle in MCF-7 human breast cancer cells. J Membr Biol. 1999 Sep 1;171(1):35-46. PubMed PMID: 10485992.1

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