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QX-314 bromide

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names：
QX-314 bromide (N-Ethyllidocaine bromide), Na+ channel blocker
CAS號(hào)：
21306-56-9
MDL Number：
MF(分子式)： C16H27BrN2O MW(分子量)： 343.309
EINECS: Reaxys Number:
Pubchem ID:9884487 Brand:BIOFOUNT

QX-314 bromide (N-Ethyllidocaine bromide), Na+ channel blocker(21306-56-9)是一種不透膜的利多卡因衍生物，當(dāng)通過 TRPV1 通道在細(xì)胞內(nèi)遞送時(shí)，它選擇性地阻斷傷害性神經(jīng)元上的鈉通道，但據(jù)報(bào)道對(duì)細(xì)胞外應(yīng)用無效。當(dāng)與 1 µM 辣椒素結(jié)合使用時(shí)，一種 TRPV1 受體激動(dòng)劑，5 mM QX-314 可阻斷電壓鉗制傷害性 DRG 神經(jīng)元中 98% 的鈉電流。

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中文別名	QX-314 bromide(21306-56-9);Na+通道阻滯劑;鈉離子通道阻滯劑
英文別名	QX-314 bromide (N-Ethyllidocaine bromide), Na+ channel blocker(21306-56-9);Lidocaine N-ethyl bromide
CAS號(hào)	21306-56-9
Inchi	InChI=1S/C16H26N2O.BrH/c1-6-18(7-2,8-3)12-15(19)17-16-13(4)10-9-11-14(16)5;/h9-11H,6-8,12H2,1-5H3;1H
InchiKey	DLHMKHREUTXMCH-UHFFFAOYSA-N
分子式 Formula	C16H27BrN2O
分子量 Molecular Weight	343.309
溶解度Solubility
性狀	Solid powder
儲(chǔ)藏條件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

QX-314 bromide (N-Ethyllidocaine bromide), Na+ channel blocker(21306-56-9)實(shí)驗(yàn)注意事項(xiàng)：
1.使用10034-96-5實(shí)驗(yàn)前需戴好防護(hù)眼鏡，穿戴防護(hù)服和口罩，佩戴手套，避免與皮膚接觸。
2.使用10034-96-5實(shí)驗(yàn)過程中如遇到有毒或者刺激性物質(zhì)及有害物質(zhì)產(chǎn)生，必要時(shí)實(shí)驗(yàn)操作需要手套箱內(nèi)完成以免對(duì)實(shí)驗(yàn)人員造成傷害。
3.取樣品10034-96-5的移液槍頭需及時(shí)更換，必要時(shí)為避免交叉污染盡可能選擇濾芯吸頭。
4.稱量藥品時(shí)選用稱量紙，并無風(fēng)處取藥和稱量以免揚(yáng)撒，試劑的容器使用前務(wù)必確保干凈，并消毒。
5.取藥品10034-96-5時(shí)盡量采用多個(gè)藥勺分別使用，使用后清洗干凈。
6.實(shí)驗(yàn)后產(chǎn)生的廢棄物需分類存儲(chǔ)，并交于專業(yè)生物廢氣物處理公司處理，以免造成環(huán)境污染。
大規(guī)格定制：定制產(chǎn)品請(qǐng)將信息發(fā)送至sales@bio-fount.com。
Experimental considerations:
1. Wear protective glasses, protective clothing and masks, gloves, and avoid contact with the skin during the experiment.
2. The waste generated after the experiment needs to be stored separately, and handed over to a professional biological waste gas treatment company to avoid environmental pollution.

產(chǎn)品說明	QX-314 bromide (N-Ethyllidocaine bromide), Na+ channel blocker(21306-56-9)是一種不透膜的利多卡因衍生物，當(dāng)通過 TRPV1 通道在細(xì)胞內(nèi)遞送時(shí)，它選擇性地阻斷傷害性神經(jīng)元上的鈉通道
Introduction	Lidocaine N-ethyl bromide is a non-membrane-permeable blocker of fast Na+-dependent action potentials and voltage-dependent, non-inactivating Na+ conductance.
Application1
Application2
Application3

警示圖
危險(xiǎn)性	Warning
危險(xiǎn)性警示	P264處理后徹底清洗+P280戴防護(hù)手套/穿防護(hù)服/戴防護(hù)眼罩/戴防護(hù)面具+P305如果進(jìn)入眼睛+P351用水小心沖洗幾分鐘+P338取出隱形眼鏡（如果有）并且易于操作,繼續(xù)沖洗+P337如果眼睛刺激持續(xù)+P313獲得醫(yī)療建議/護(hù)理
安全聲明	H315 H319 H335
安全防護(hù)	P264 P302+P352 P304+P340 P305+P351+P338 P332+P313 P337+P313
備注

[1]Yin Q, Ke B, Chen X, Guan Y, Feng P, Chen G, Kang Y, Zhang W, Nie Y. Effects of Liposomes Charge on Extending Sciatic Nerve Blockade of N-ethyl Bromide of Lidocaine in Rats. Sci Rep. 2016 Dec 7;

[2]Binshtok, A.M., Bean, B.P., and Woolf, C.J. Inhibition of nociceptors by TRPV1-mediated entry of impermeant sodium channel blockers. Nature 449, 607-610 (2007).

[3]Brenneis C, Kistner K, Puopolo M, Jo S, Roberson D, Sisignano M, Segal D, Cobos EJ, Wainger BJ, Labocha S, Ferreirós N, von Hehn C, Tran J, Geisslinger G, Reeh PW, Bean BP, Woolf CJ. Bupivacaine-induced cellular entry of QX-314 and its contribution to differential nerve block. Br J Pharmacol. 2014 Jan;171(2):438-51. doi: 10.1111/bph.12466. PubMed PMID: 24117225; PubMed Central PMCID: PMC3904263.

[4]Roberson DP, Binshtok AM, Blasl F, Bean BP, Woolf CJ. Targeting of sodium channel blockers into nociceptors to produce long-duration analgesia: a systematic study and review. Br J Pharmacol. 2011 Sep;164(1):48-58. doi: 10.1111/j.1476-5381.2011.01391.x. Review. PubMed PMID: 21457220; PubMed Central PMCID: PMC3171859.

[5] Inan S, Dun NJ, Cowan A. Inhibitory effect of lidocaine on pain and itch using formalin-induced nociception and 5'-guanidinonaltrindole-induced scratching models in mice: behavioral and neuroanatomical evidence. Eur J Pharmacol. 2009 Aug 15;616(1-3):141-6. doi: 10.1016/j.ejphar.2009.06.026. Epub 2009 Jun 21. PubMed PMID: 19549515; PubMed Central PMCID: PMC2735214.

5: Bonjardim LR, da Silva AP, Gameiro GH, Tambeli CH, Ferraz de Arruda Veiga MC. Nociceptive behavior induced by mustard oil injection into the temporomandibular joint is blocked by a peripheral non-opioid analgesic and a central opioid analgesic. Pharmacol Biochem Behav. 2009 Jan;91(3):321-6. doi: 10.1016/j.pbb.2008.08.001. Epub 2008 Aug 8. PubMed PMID: 18755210.

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