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Levoxadrol

NMR下載 COA and HPLC MSDS下載
names：
(2R)-2-[(4R)-2,2-Diphenyl-1,3-dioxolan-4-yl]piperidine
CAS號：
4792-18-1
MDL Number：
MF(分子式)： C20H23NO2 MW(分子量)： 309.4
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文別名	Levoxadrol
英文別名	Levoxadrol;
CAS號	4792-18-1
Inchi	InChI=1S/C20H23NO2/c1-3-9-16(10-4-1)20(17-11-5-2-6-12-17)22-15-19(23-20)18-13-7-8-14-21-18/h1-6,9-12,18-19,21H,7-8,13-15H2/t18-,19+/m1/s1
InchiKey	HGKAMARNFGKMLC-MOPGFXCFSA-N
分子式 Formula	C20H23NO2
分子量 Molecular Weight	309.4
溶解度Solubility
性狀	Solid powder
儲藏條件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

產(chǎn)品說明	Levoxadrol(CAS:4792-18-1):僅限應(yīng)用于工業(yè)或者科學(xué)研究過程中非醫(yī)療目的，不應(yīng)用于人類或動物的臨床診斷以及治過程療，該產(chǎn)品非藥用，非食用。
Introduction	Levoxadrol is an inhibitor of the phencyclidine (PCP) receptor. It acts by producing morphine-like antinociception and sedation, relieving pain without the loss of consciousness.
Application1
Application2
Application3

警示圖
危險性	Warning
危險性警示
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備注

[1]Grant KA, Colombo G, Grant J, Rogawski MA. Dizocilpine-like discriminative stimulus effects of low-affinity uncompetitive NMDA antagonists. Neuropharmacology. 1996;35(12):1709-19. PubMed PMID: 9076750.

[2]Pechnick RN, Poland RE. Neuroendocrine responses produced by enantiomeric pairs of drugs that interact with phencyclidine and sigma receptors. Eur J Pharmacol. 1994 Sep 22;263(1-2):115-20. PubMed PMID: 7821343.

[3] Jamieson GA, Agrawal AK, Greco NJ, Tenner TE Jr, Jones GD, Rice KC, Jacobson AE, White JG, Tandon NN. Phencyclidine binds to blood platelets with high affinity and specifically inhibits their activation by adrenaline. Biochem J. 1992 Jul 1;285 ( Pt 1):35-9. PubMed PMID: 1322125; PubMed Central PMCID: PMC1132740.

[4] Domino EF. Chemical dissociation of human awareness: focus on non-competitive NMDA receptor antagonists. J Psychopharmacol. 1992 Jan;6(3):418-24. doi: 10.1177/026988119200600312. PubMed PMID: 22291389.

[5] Haring R, Pellegrini-Giampietro DE, Zukin SR, Zukin RS, Scheideler MA. High efficiency reconstitution of a phencyclidine/MK-801 receptor binding site solubilized from rat forebrain membranes. Mol Pharmacol. 1991 Nov;40(5):666-73. PubMed PMID: 1658603.

6: Brog JS, Beinfeld MC. Inhibition of carbachol-induced inositol phosphate accumulation by phencyclidine, phencyclidine-like ligands and sigma agonists involves blockade of the muscarinic cholinergic receptor: a novel dioxadrol-preferring interaction. J Pharmacol Exp Ther. 1990 Sep;254(3):952-6. PubMed PMID: 2203900.7: Mount H, Boksa P, Chaudieu I, Quirion R. Phencyclidine and related compounds evoked [3H]dopamine release from rat mesencephalic cell cultures by a mechanism independent of the phencyclidine receptor, sigma binding site, or dopamine uptake site. Can J Physiol Pharmacol. 1990 Sep;68(9):1200-6. PubMed PMID: 1980428.8: Allard LR, Brog JS, Viereck JC, Contreras PC, Jacobson AE, Rice KC, Beinfeld MC. Inhibition of potassium-evoked release of cholecystokinin from rat caudate-putamen, cerebral cortex and hippocampus incubated in vitro by phencyclidine and related compounds. Brain Res. 1990 Jul 9;522(2):224-6. PubMed PMID: 2171716.9: ffrench-Mullen JM, Rogawski MA. Interaction of phencyclidine with voltage-dependent potassium channels in cultured rat hippocampal neurons: comparison with block of the NMDA receptor-ionophore complex. J Neurosci. 1989 Nov;9(11):4051-61. PubMed PMID: 2555461.10: Pechnick RN, Wong CA, George R, Thurkauf A, Jacobson AE, Rice KC. Comparison of the effects of the acute administration of dexoxadrol, levoxadrol, MK-801 and phencyclidine on body temperature in the rat. Neuropharmacology. 1989 Aug;28(8):829-35. PubMed PMID: 2674766.1

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