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Levorphanol hydrobromide

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names：
(4bR,8aR,9R)-11-methyl-6,7,8,8a,9,10-hexahydro-5H-9,4b-(epiminoethano)phenanthren-3-ol hydrobromide
CAS號(hào)：
17140-05-5
MDL Number：
MF(分子式)： C17H24BrNO MW(分子量)： 338.28
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文別名	Levorphanol hydrobromide
英文別名	Levorphanol hydrobromide; l-Dromoran hydrobromide; Methorphinan hydrobromide;
CAS號(hào)	17140-05-5
Inchi	InChI=1S/C17H23NO.BrH/c1-18-9-8-17-7-3-2-4-14(17)16(18)10-12-5-6-13(19)11-15(12)17;/h5-6,11,14,16,19H,2-4,7-10H2,1H3;1H/t14-,16+,17+;/m0./s1
InchiKey	WVFGKGPFQSEWON-DYWKTHLTSA-N
分子式 Formula	C17H24BrNO
分子量 Molecular Weight	338.28
溶解度Solubility
性狀	Solid powder
儲(chǔ)藏條件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

產(chǎn)品說(shuō)明	Levorphanol hydrobromide(CAS:17140-05-5):僅限應(yīng)用于工業(yè)或者科學(xué)研究過(guò)程中非醫(yī)療目的，不應(yīng)用于人類(lèi)或動(dòng)物的臨床診斷以及治過(guò)程療，該產(chǎn)品非藥用，非食用。
Introduction	Levorphanol hydrobromide is an opioid medication used to treat moderate to severe pain. It is one of four enantiomers of the compound racemorphan, and was first described in Germany in 1948 as an orally active, morphine-like analgesic. Levorphanol hydrobromide is discontinued (DEA controlled substance).
Application1
Application2
Application3

警示圖
危險(xiǎn)性	Warning
危險(xiǎn)性警示
安全聲明
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[1]Larrey D, Babany G, Tinel M, Freneaux E, Amouyal G, Habersetzer F, Letteron P, Pessayre D. Effect of liver disease on dextromethorphan oxidation capacity and phenotype: a study in 107 patients. Br J Clin Pharmacol. 1989 Sep;28(3):297-304. PubMed PMID: 2789923; PubMed Central PMCID: PMC1379948.

[2]Larrey D, Tinel M, Amouyal G, Freneaux E, Berson A, Fouin-Fortunet H, Babany G, Letteron P, Iglicki F, Slama JL, et al. Genetically determined oxidation polymorphism and drug hepatotoxicity. Study of 51 patients. J Hepatol. 1989 Mar;8(2):158-64. PubMed PMID: 2715619.

[3] Vetticaden SJ, Cabana BE, Prasad VK, Purich ED, Jonkman JH, de Zeeuw R, Ball L, Leeson LJ, Braun RL. Phenotypic differences in dextromethorphan metabolism. Pharm Res. 1989 Jan;6(1):13-9. PubMed PMID: 2717511.

[4] Chen TM, Pacifico JR, Daly RE. High-pressure liquid chromatographic assay of dextromethorphan hydrobromide, guaifenesin, and sodium benzoate in an expectorant syrup. J Chromatogr Sci. 1988 Dec;26(12):636-9. PubMed PMID: 3230118.

[5] Murtha JL, Julian TN, Radebaugh GW. Simultaneous determination of pseudoephedrine hydrochloride, chlorpheniramine maleate, and dextromethorphan hydrobromide by second-derivative photodiode array spectroscopy. J Pharm Sci. 1988 Aug;77(8):715-8. PubMed PMID: 3210162.

6: Svensson CK, Ware JA. Dextromethorphan pretreatment induces antipyrine clearance in the rat. Pharm Res. 1988 Jul;5(7):437-9. PubMed PMID: 3247313.7: Larrey D, Amouyal G, Tinel M, Letteron P, Berson A, Labbe G, Pessayre D. Polymorphism of dextromethorphan oxidation in a French population. Br J Clin Pharmacol. 1987 Nov;24(5):676-9. PubMed PMID: 3435696; PubMed Central PMCID: PMC1386343.8: Fleming PM. Dependence on dextromethorphan hydrobromide. Br Med J (Clin Res Ed). 1986 Sep 6;293(6547):597. PubMed PMID: 3092943; PubMed Central PMCID: PMC1341386.9: Schmid B, Bircher J, Preisig R, Küpfer A. Polymorphic dextromethorphan metabolism: co-segregation of oxidative O-demethylation with debrisoquin hydroxylation. Clin Pharmacol Ther. 1985 Dec;38(6):618-24. PubMed PMID: 4064464.10: Das Gupta V, Heble AR. Quantitation of acetaminophen, chlorpheniramine maleate, dextromethorphan hydrobromide, and phenylpropanolamine hydrochloride in combination using high-performance liquid chromatography. J Pharm Sci. 1984 Nov;73(11):1553-6. PubMed PMID: 6520756.1

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