購物車 
-
Leinamycin
- names：
(2Z,9E,13Z,15E)-4',11-dihydroxy-2,4',9-trimethylspiro[3-aza-1(2,4)-thiazolacyclohexadecaphanene-6,3'-[1,2]dithiolane]-9,13,15-triene-4,5',12-trione 2'-oxide
- CAS號：
120500-15-4
MDL Number： - MF(分子式)： C22H26N2O6S3 MW(分子量)： 510.63
- EINECS: Reaxys Number:
- Pubchem ID: Brand:BIOFOUNT
| 貨品編碼 | 規(guī)格 | 純度 | 價格 (￥) | 現(xiàn)價(￥) | 特價(￥) | 庫存描述 | 數(shù)量 | 總計 (￥) |
|---|---|---|---|---|---|---|---|---|
| FMK17423-100mg | 100mg | >98% | ￥ 0.00 | ￥ 0.00 | Get quote | ￥ 0.00 |
| 中文別名 | Leinamycin |
| 英文別名 | Leinamycin; Antibiotic DC 107; DC 107; DC-107; DC107; (+)-Leinamycin; |
| CAS號 | 120500-15-4 |
| Inchi | InChI=1S/C22H26N2O6S3/c1-13-8-9-22(21(3,29)20(28)32-33(22)30)11-18(27)23-14(2)19-24-15(12-31-19)6-4-5-7-16(25)17(26)10-13/h4-7,10,12,14,17,26,29H,8-9,11H2,1-3H3,(H,23,27)/b6-4+,7-5-,13-10+ |
| InchiKey | ZHTRILQJTPJGNK-WQGJMKSQSA-N |
| 分子式 Formula | C22H26N2O6S3 |
| 分子量 Molecular Weight | 510.63 |
| 溶解度Solubility | |
| 性狀 | Solid powder |
| 儲藏條件 Storage conditions | Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years). |
| 產(chǎn)品說明 | Leinamycin(CAS:120500-15-4):僅限應用于工業(yè)或者科學研究過程中非醫(yī)療目的，不應用于人類或動物的臨床診斷以及治過程療，該產(chǎn)品非藥用，非食用。 |
| Introduction | Leinamycin is a thiazole containing macrolide characterized by an unusual 1,3-dioxo-1,2-dithiolane moiety that is spiro fused to an 18 member macrolactam ring; isolated from Streptomyces; possible DNA alkylator; the leinamycin biosynthetic gene cluster from Streptomyces atroolivaceus S-140 consists of two polyketide synthases genes. |
| Application1 | |
| Application2 | |
| Application3 |
| [1]Huang SX, Yun BS, Ma M, Basu HS, Church DR, Ingenhorst G, Huang Y, Yang D, Lohman JR, Tang GL, Ju J, Liu T, Wilding G, Shen B. Leinamycin E1 acting as an anticancer prodrug activated by reactive oxygen species. Proc Natl Acad Sci U S A. 2015 Jul 7;112(27):8278-83. doi: 10.1073/pnas.1506761112. Epub 2015 Jun 8. PubMed PMID: 26056295; PubMed Central PMCID: PMC4500275. |
| [2]Keerthi K, Rajapakse A, Sun D, Gates KS. Synthesis and characterization of a small analogue of the anticancer natural product leinamycin. Bioorg Med Chem. 2013 Jan 1;21(1):235-41. doi: 10.1016/j.bmc.2012.10.021. Epub 2012 Oct 27. PubMed PMID: 23168080; PubMed Central PMCID: PMC3532941. |
| [3] Viswesh V, Hays AM, Gates K, Sun D. DNA cleavage induced by antitumor antibiotic leinamycin and its biological consequences. Bioorg Med Chem. 2012 Jul 15;20(14):4413-21. doi: 10.1016/j.bmc.2012.05.033. Epub 2012 May 23. PubMed PMID: 22682923; PubMed Central PMCID: PMC3389147. |
| [4] Katt WP, Cerione RA. Less than the sum of its parts, a leinamycin precursor has superior properties. Proc Natl Acad Sci U S A. 2015 Jul 7;112(27):8164-5. doi: 10.1073/pnas.1510122112. Epub 2015 Jun 23. PubMed PMID: 26106161; PubMed Central PMCID: PMC4500279. |
| [5] Sivaramakrishnan S, Breydo L, Sun D, Gates KS. The macrocycle of leinamycin imparts hydrolytic stability to the thiol-sensing 1,2-dithiolan-3-one 1-oxide unit of the natural product. Bioorg Med Chem Lett. 2012 Jun 1;22(11):3791-4. doi: 10.1016/j.bmcl.2012.04.003. Epub 2012 Apr 12. PubMed PMID: 22560586; PubMed Central PMCID: PMC3376404. |
6: Liu T, Ma M, Ge HM, Yang C, Cleveland J, Shen B. Synthesis and evaluation of 8,4'-dideshydroxy-leinamycin revealing new insights into the structure-activity relationship of the anticancer natural product leinamycin. Bioorg Med Chem Lett. 2015 Nov 1;25(21):4899-4902. doi: 10.1016/j.bmcl.2015.05.078. Epub 2015 May 30. PubMed PMID: 26071634; PubMed Central PMCID: PMC4607584.7: Lohman JR, Bingman CA, Phillips GN Jr, Shen B. Structure of the bifunctional acyltransferase/decarboxylase LnmK from the leinamycin biosynthetic pathway revealing novel activity for a double-hot-dog fold. Biochemistry. 2013 Feb 5;52(5):902-11. doi: 10.1021/bi301652y. Epub 2013 Jan 24. PubMed PMID: 23320975; PubMed Central PMCID: PMC3567400.8: Viswesh V, Gates K, Sun D. Characterization of DNA damage induced by a natural product antitumor antibiotic leinamycin in human cancer cells. Chem Res Toxicol. 2010 Jan;23(1):99-107. doi: 10.1021/tx900301r. PubMed PMID: 20017514; PubMed Central PMCID: PMC2810146.9: Huang Y, Tang GL, Pan G, Chang CY, Shen B. Characterization of the Ketosynthase and Acyl Carrier Protein Domains at the LnmI Nonribosomal Peptide Synthetase-Polyketide Synthase Interface for Leinamycin Biosynthesis. Org Lett. 2016 Sep 2;18(17):4288-91. doi: 10.1021/acs.orglett.6b02033. Epub 2016 Aug 19. PubMed PMID: 27541042; PubMed Central PMCID: PMC5013926.10: Huang Y, Yang D, Pan G, Tang GL, Shen B. Characterization of LnmO as a pathway-specific Crp/Fnr-type positive regulator for leinamycin biosynthesis in Streptomyces atroolivaceus and its application for titer improvement. Appl Microbiol Biotechnol. 2016 Dec;100(24):10555-10562. Epub 2016 Oct 5. PubMed PMID: 27704182; PubMed Central PMCID: PMC5121087.1
對不起，暫無產(chǎn)品評價！
MSDS
SDS 1.0 中文
展開
SDS 1.0 英文
展開
- 相關產(chǎn)品
-
< >
- 推薦產(chǎn)品
-
< >
- 最新產(chǎn)品
-
< >
新聞
怎么做細胞爬片免疫組化染色實驗
細胞爬片免疫組化染色，是通過細胞爬片是讓玻片浸在細胞培養(yǎng)基內(nèi)，細胞在玻片上生長，主要用于組織學，免疫組織化學...
2020/7/20 22:04:33
提取病毒RNA的實驗方法
提取病毒RNA方法分別有：異硫氰酸胍的提取病毒RNA方法、TRIzol LS提取法、Trizol法提取法等等...
2020/7/22 20:29:26
chelex 100樹脂國產(chǎn)替代之路-BIOFOUNT范德生物
Chelex 100螯合離子交換樹脂對銅、鐵和其他重金屬?的偏好顯著高于對鈉、鉀等一價陽離子的偏好。它對二價...
2025/11/4 14:22:46
9月開學季——助研新學期 范德送好禮
2025/8/28 15:30:55
Waxfilm 實驗室封口膜：技術與國際市場的雙重突破
在實驗室耗材領域，封口膜是保障實驗準確性與穩(wěn)定性的關鍵產(chǎn)品之一。近年來，Waxfilm?實驗室封口膜憑借其卓...
2025/5/13 13:03:40
Waxfilm實驗室封口膜的5大突破
Waxfilm實驗室封口膜作為生物功能膜領域的國產(chǎn)技術突破和品牌突破，是生物領域中國技術發(fā)展的縮影。
2025/5/6 17:02:07
各種微流控芯片鍵合方法的優(yōu)缺點
微流控芯片鍵合：目前主要有激光焊接、熱壓鍵合、膠鍵合、超音波焊接，每種方法都有各自的優(yōu)缺點。本文主要介紹聚酯...
2023/7/28 10:43:09
新一代微流控鍵合解決方案
微流控鍵合解決方案：微流控芯片制造的一個重要環(huán)節(jié)，也是最容易被忽視的--芯片鍵合。其中一個重要因素是：微流控...
2023/7/27 12:44:28
熒光素鉀鹽使用說明
D-熒光素鉀鹽（K+）設計用于體外和體內(nèi)生物發(fā)光測定。D-熒光素的質(zhì)量和純度對于獲得良好和可重復的結(jié)果至關重...
2023/7/20 11:05:11
如何選BSA（牛血清白蛋白）
如何選BSA（牛血清白蛋白）：牛血清白蛋白（BSA）有多種形式，如何選擇適合自己的牛血清白蛋白（BSA）是一...
2023/2/14 13:09:18
