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Lateritin

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names：
3-benzyl-6-isopropyl-4-methylmorpholine-2,5-dione
CAS號：
65454-13-9
MDL Number：
MF(分子式)： C15H19NO3 MW(分子量)： 261.31
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文別名	Lateritin
英文別名	Lateritin; Bassiatin;
CAS號	65454-13-9
Inchi	InChI=1S/C15H19NO3/c1-10(2)13-14(17)16(3)12(15(18)19-13)9-11-7-5-4-6-8-11/h4-8,10,12-13H,9H2,1-3H3
InchiKey	YOKBTBNVNCFOBF-UHFFFAOYSA-N
分子式 Formula	C15H19NO3
分子量 Molecular Weight	261.31
溶解度Solubility
性狀	Solid powder
儲藏條件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

產(chǎn)品說明	Lateritin(CAS:65454-13-9):僅限應(yīng)用于工業(yè)或者科學(xué)研究過程中非醫(yī)療目的，不應(yīng)用于人類或動物的臨床診斷以及治過程療，該產(chǎn)品非藥用，非食用。
Introduction	Lateritin is An Acyl-CoAcholesterol acyltransferase (ACAT) inhibitor and a platelet aggregation inhibitor isolated from the mycelial cake of Gibberella lateritium; bassiatin is the (3S,6R) isomer.
Application1
Application2
Application3

警示圖
危險性	Warning
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[1]Pettit RK, Pettit GR, Xu JP, Weber CA, Richert LA. Isolation of human cancer cell growth inhibitory, antimicrobial lateritin from a mixed fungal culture. Planta Med. 2010 Mar;76(5):500-[1]doi: 10.1055/s-0029-1240617. Epub 2009 Nov 25. PubMed PMID: 19941263.

[2]Hasumi K, Shinohara C, Iwanaga T, Endo A. Lateritin, a new inhibitor of acyl-CoA:cholesterol acyltransferase produced by Gibberella lateritium IFO 7188. J Antibiot (Tokyo). 1993 Dec;46(12):1782-7. PubMed PMID: 8294234.

[3] Meng L, Tao H, Dong G, Yang T, Zhang W, Zhu W, Huang C. ERK1/2 and Akt pathway activated during (3R,6R)-bassiatin(1)-induced apoptosis in MCF-7 cells. Cell Biol Int. 2012 Apr 1;36(4):345-8. doi: 10.1042/CBI20110388. PubMed PMID: 22150072.

[4] Meng L, Feng B, Tao H, Yang T, Meng Y, Zhu W, Huang C. A novel antioestrogen agent (3R,6R)-bassiatin inhibits cell proliferation and cell cycle progression by repressing cyclin D1 expression in 17β-oestradiol-treated MCF-7 cells. Cell Biol Int. 2011 Jun;35(6):599-605. doi: 10.1042/CBI20100765. PubMed PMID: 21241249.

[5] Kagamizono T, Nishino E, Matsumoto K, Kawashima A, Kishimoto M, Sakai N, He BM, Chen ZX, Adachi T, Morimoto S, et al. Bassiatin, a new platelet aggregation inhibitor produced by Beauveria bassiana K-717. J Antibiot (Tokyo). 1995 Dec;48(12):1407-12. PubMed PMID: 8557595.

6: Tang CY, Chen YW, Jow GM, Chou CJ, Jeng CJ. Beauvericin activates Ca2+-activated Cl- currents and induces cell deaths in Xenopus oocytes via influx of extracellular Ca2+. Chem Res Toxicol. 2005 May;18(5):825-33. PubMed PMID: 15892576.7: Oh H, Kim T, Oh GS, Pae HO, Hong KH, Chai KY, Kwon TO, Chung HT, Lee HS. (3R,6R)-4-methyl-6-(1-methylethyl)-3-phenylmethyl-perhydro-1,4-oxazine-2,5-dione: an apoptosis-inducer from the fruiting bodies of Isaria japonica. Planta Med. 2002 Apr;68(4):345-8. PubMed PMID: 11988860.8: Hughes AB, Sleebs MM. Total synthesis of bassiatin and its stereoisomers: novel divergent behavior of substrates in Mitsunobu cyclizations. J Org Chem. 2005 Apr 15;70(8):3079-88. PubMed PMID: 15822967.9: Jow GM, Chou CJ, Chen BF, Tsai JH. Beauvericin induces cytotoxic effects in human acute lymphoblastic leukemia cells through cytochrome c release, caspase 3 activation: the causative role of calcium. Cancer Lett. 2004 Dec 28;216(2):165-73. PubMed PMID: 15533592.10: Huang LH, Chen YX, Yu JC, Yuan J, Li HJ, Ma WZ, Watanapokasin R, Hu KC, Niaz SI, Yang DP, Lan WJ. Secondary Metabolites from the Marine-Derived Fungus Dichotomomyces sp. L-8 and Their Cytotoxic Activity. Molecules. 2017 Mar 11;22(3). pii: E444. doi: 10.3390/molecules22030444. PubMed PMID: 28287456.1

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