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L 858051

NMR下載 COA and HPLC MSDS下載
names：
(3R,4aR,5S,6S,6aS,10S,10aR,10bS)-6,10,10b-trihydroxy-3,4a,7,7,10a-pentamethyl-1-oxo-3-vinyldodecahydro-1H-benzo[f]chromen-5-yl 4-(4-methylpiperazin-1-yl)butanoate
CAS號：
110452-75-0
MDL Number：
MF(分子式)： C29H48N2O7 MW(分子量)： 536.71
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文別名	L 858051
英文別名	L 858051; L-858051; L858051; 7B-Forskolin; Dmpb-forskolin;
CAS號	110452-75-0
Inchi	InChI=1S/C29H48N2O7/c1-8-26(4)18-20(33)29(36)27(5)19(32)11-12-25(2,3)23(27)22(35)24(28(29,6)38-26)37-21(34)10-9-13-31-16-14-30(7)15-17-31/h8,19,22-24,32,35-36H,1,9-18H2,2-7H3/t19-,22-,23-,24-,26-,27-,28+,29-/m0/s1
InchiKey	PAYHDZDDAHVPDU-ZQVYKFDISA-N
分子式 Formula	C29H48N2O7
分子量 Molecular Weight	536.71
溶解度Solubility
性狀	Solid powder
儲藏條件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

產(chǎn)品說明	L 858051(CAS:110452-75-0):僅限應(yīng)用于工業(yè)或者科學(xué)研究過程中非醫(yī)療目的，不應(yīng)用于人類或動物的臨床診斷以及治過程療，該產(chǎn)品非藥用，非食用。
Introduction	L 858051 activates adenylate cyclase and inhibits glucose transport in rat adipocytes.
Application1
Application2
Application3

警示圖
危險性	Warning
危險性警示
安全聲明
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備注

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5:118-128. doi: 10.1016/j.cellsig.2017.03.025. Epub 2017 Apr 4. PubMed PMID: 28389413.

[3]Haj Slimane Z, Bedioune I, Lechêne P, Varin A, Lefebvre F, Mateo P, Domergue-Dupont V, Dewenter M, Richter W, Conti M, El-Armouche A, Zhang J, Fischmeister R, Vandecasteele G. Control of cytoplasmic and nuclear protein kinase A by phosphodiesterases and phosphatases in cardiac myocytes. Cardiovasc Res. 2014 Apr 1;102(1):97-106. doi: 10.1093/cvr/cvu029. Epub 2014 Feb 18. PubMed PMID: 24550350; PubMed Central PMCID: PMC3958623.

[4]Funaki C, Hodges RR, Dartt DA. Role of cAMP inhibition of p44/p42 mitogen-activated protein kinase in potentiation of protein secretion in rat lacrimal gland. Am J Physiol Cell Physiol. 2007 Nov;293(5):C1551-60. Epub 2007 Aug 8. PubMed PMID: 17687004.

[5] Rochais F, Vandecasteele G, Lefebvre F, Lugnier C, Lum H, Mazet JL, Cooper DM, Fischmeister R. Negative feedback exerted by cAMP-dependent protein kinase and cAMP phosphodiesterase on subsarcolemmal cAMP signals in intact cardiac myocytes: an in vivo study using adenovirus-mediated expression of CNG channels. J Biol Chem. 2004 Dec 10;279(50):52095-105. Epub 2004 Oct 1. PubMed PMID: 15466415.

5: Loir M. Adenosine receptor-adenylate cyclase system in the trout testis: involvement in the regulation of germ cell proliferation. Mol Reprod Dev. 2001 Mar;58(3):307-17. PubMed PMID: 11170272.

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