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L 651896

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names：
(E)-6-(3-(2-(hydroxymethyl)phenyl)allyl)-2,3-dihydrobenzofuran-5-ol
CAS號(hào)：
99134-29-9
MDL Number：
MF(分子式)： C18H18O3 MW(分子量)： 282.33
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文別名	L 651896
英文別名	L 651896; L-651896; L651896;
CAS號(hào)	99134-29-9
Inchi	InChI=1S/C18H18O3/c19-12-16-5-2-1-4-13(16)6-3-7-14-11-18-15(8-9-21-18)10-17(14)20/h1-6,10-11,19-20H,7-9,12H2/b6-3+
InchiKey	RRKABGWFFMSVQH-ZZXKWVIFSA-N
分子式 Formula	C18H18O3
分子量 Molecular Weight	282.33
溶解度Solubility
性狀	Solid powder
儲(chǔ)藏條件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

產(chǎn)品說(shuō)明	L 651896(CAS:99134-29-9):僅限應(yīng)用于工業(yè)或者科學(xué)研究過(guò)程中非醫(yī)療目的，不應(yīng)用于人類(lèi)或動(dòng)物的臨床診斷以及治過(guò)程療，該產(chǎn)品非藥用，非食用。
Introduction	L 651896 is a 5-lipoxygenase inhibitor.
Application1
Application2
Application3

警示圖
危險(xiǎn)性	Warning
危險(xiǎn)性警示
安全聲明
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[1]Millichamp NJ, Dziezyc J, Rohde BH, Chiou GC, Smith WB. Acute effects of anti-inflammatory drugs on neodymium:yttrium aluminum garnet laser-induced uveitis in dogs. Am J Vet Res. 1991 Aug;52(8):1279-84. PubMed PMID: 1656823.

[2]Hammond ML, Zambias RA, Chang MN, Jensen NP, McDonald J, Thompson K, Boulton DA, Kopka IE, Hand KM, Opas EE, et al. Antioxidant-based inhibitors of leukotriene biosynthesis. The discovery of 6-[1-[2-(hydroxymethyl)phenyl]-1-propen-3-yl]-2,3-dihydro-5- benzofuranol, a potent topical antiinflammatory agent. J Med Chem. 1990 Mar;33(3):908-18. PubMed PMID: 2308140.

[3] Dembinska-Kiec A, Novak P, Peskar BM, Peskar BA. Release of cysteinyl leukotrienes is of minor importance in platelet-activating factor-induced reduction of perfusion rate in the rat gastric vascular bed. Prog Clin Biol Res. 1989;301:487-91. PubMed PMID: 2798459.

[4] Dembinska-Kiec A, Peskar BA, Muller MK, Peskar BM. The effects of platelet-activating factor on flow rate and eicosanoid release in the isolated perfused rat gastric vascular bed. Prostaglandins. 1989 Jan;37(1):69-91. PubMed PMID: 2717778.

[5] Jones TR, Charette L, Denis D. Leukotriene and anti-IgE induced contractions of human isolated trachea: studies with leukotriene receptor antagonists and a novel 5-lipoxygenase inhibitor. Can J Physiol Pharmacol. 1988 Jun;66(6):762-8. PubMed PMID: 2844372.

6: Matuszewski BK, Constanzer ML, Bayne WF. Determination of 2,3-dihydro-6-[3-(2-hydroxymethyl)phenyl-2-propenyl]-5-benzofuranol in plasma using liquid chromatography with electrochemical detection. J Chromatogr. 1988 Apr 29;426(2):295-304. PubMed PMID: 3392142.7: Bonney RJ, Davies P, Dougherty H, Egan RW, Gale PH, Chang M, Hammond M, Jensen N, MacDonald J, Thompson K, et al. Biochemical and biological activities of 2,3-dihydro-6-[3-(2-hydroxymethyl)phenyl-2-propenyl]-5-benzofuranol (L-651,896), a novel topical anti-inflammatory agent. Biochem Pharmacol. 1987 Nov 15;36(22):3885-91. PubMed PMID: 3120729.8: Garceau D, Ford-Hutchinson AW, Charleson S. 5-Lipoxygenase inhibitors and allergic conjunctivitis reactions in the guinea-pig. Eur J Pharmacol. 1987 Nov 3;143(1):1-7. PubMed PMID: 2826183.9: Chan CC, Dubois L, Young V. Effects of two novel inhibitors of 5-lipoxygenase, L-651,392 and L-651,896, in a guinea-pig model of epidermal hyperproliferation. Eur J Pharmacol. 1987 Jul 2;139(1):11-8. PubMed PMID: 2820754.

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