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KB 5666

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names：
Quinazoline, 4-(pentyloxy)-2-(4-(2-propenyl)-1-piperazinyl)-, (E)-2-butenedioate (11)
CAS號(hào)：
131916-69-3
MDL Number：
MF(分子式)： C24H32N4O5 MW(分子量)： 456.54
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文別名	KB 5666
英文別名	KB 5666; KB-5666; KB5666;
CAS號(hào)	131916-69-3
Inchi	InChI=1S/C20H28N4O.C4H4O4/c1-3-5-8-16-25-19-17-9-6-7-10-18(17)21-20(22-19)24-14-12-23(11-4-2)13-15-24;5-3(6)1-2-4(7)8/h4,6-7,9-10H,2-3,5,8,11-16H2,1H3;1-2H,(H,5,6)(H,7,8)/b;2-1+
InchiKey	SGDNWFHKGDZSEZ-WLHGVMLRSA-N
分子式 Formula	C24H32N4O5
分子量 Molecular Weight	456.54
溶解度Solubility
性狀	Solid powder
儲(chǔ)藏條件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

產(chǎn)品說明	KB 5666(CAS:131916-69-3):僅限應(yīng)用于工業(yè)或者科學(xué)研究過程中非醫(yī)療目的，不應(yīng)用于人類或動(dòng)物的臨床診斷以及治過程療，該產(chǎn)品非藥用，非食用。
Introduction	KB 5666 is a quinazoline derivative and lipid peroxidation inhibitor. Histologic, immunohistochemical and receptor-autoradiographic data indicate that KB-5666 protects the brain from both cellular and functional consequences of ischemia.
Application1
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危險(xiǎn)性	Warning
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[1]Shimohara K, Niida H, Okabe S. Effects of KB-5492, 1-(3,4,5-trimethoxybenzyl)-4-((4-methoxyphenyl)oxycarbonylmethyl) p iperazine monofumarate monohydrate, on gastric lesions and gastric secretion in rats. Jpn J Pharmacol. 1990 Jun;53(2):275-9. PubMed PMID: 2385012.

[2]Harada Y, Hara H, Sukamoto T. Binding properties of KB-5492, a novel anti-ulcer agent, at sigma receptors in porcine gastric fundic mucosa. Eur J Pharmacol. 1994 Aug 11;261(1-2):91-6. PubMed PMID: 8001658.

[3] Harada Y, Hara H, Sukamoto T. Receptor binding profiles of KB-5492, a novel anti-ulcer agent, at sigma receptors in guinea-pig brain. Eur J Pharmacol. 1994 May 2;256(3):321-8. PubMed PMID: 8045277.

[4] Morimoto Y, Shimohara K, Oshima S, Sukamoto T. Effects of the new anti-ulcer agent KB-5492 on experimental gastric mucosal lesions and gastric mucosal defensive factors, as compared to those of teprenone and cimetidine. Jpn J Pharmacol. 1991 Dec;57(4):495-505. PubMed PMID: 1803065.

[5] Morimoto Y, Oshima S, Hara H, Sukamoto T. Effects of KB-5492, a new anti-ulcer agent, on ethanol- and acidified aspirin-induced gastric mucosal damage in vivo and in vitro. Jpn J Pharmacol. 1994 Jan;64(1):41-7. PubMed PMID: 8164392.

6: Morimoto Y, Shimohara K, Tanaka K, Hara H, Sukamoto T. 4-Methoxyphenyl 4-(3,4,5-trimethoxybenzyl)-1-piperazineacetate monofumarate monohydrate (KB-5492), a new anti-ulcer agent with a selective affinity for the sigma receptor, prevents cysteamine-induced duodenal ulcers in rats by a mechanism different from that of cimetidine. Jpn J Pharmacol. 1994 Mar;64(3):221-4. PubMed PMID: 8022123.7: Hara H, Tanaka K, Harada Y, Sukamoto T. Sigma receptor-mediated effects of a new antiulcer agent, KB-5492, on experimental gastric mucosal lesions and gastric alkaline secretion in rats. J Pharmacol Exp Ther. 1994 May;269(2):799-805. PubMed PMID: 8182548.8: Morimoto Y, Shimohara K, Oshima S, Hara H, Sukamoto T. Effects of KB-5492, a new anti-ulcer agent with a selective affinity for the sigma-receptor, on aspirin-induced disruption of the rat gastric mucosal barrier. Jpn J Pharmacol. 1994 Jan;64(1):49-55. PubMed PMID: 8164393.

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