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JWH-018

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names：
1-Pentyl-3-(1-naphthoyl) indole
CAS號(hào)：
209414-07-3
MDL Number：
MF(分子式)： C24H23NO MW(分子量)： 341.45
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文別名	JWH-018
英文別名	1-Pentyl-3-(1-naphthoyl) indole; AM-678; AM678; AM 678; JWH018; JWH 018; JWH-018
CAS號(hào)	209414-07-3
Inchi	InChI=1S/C24H23NO/c1-2-3-8-16-25-17-22(20-13-6-7-15-23(20)25)24(26)21-14-9-11-18-10-4-5-12-19(18)21/h4-7,9-15,17H,2-3,8,16H2,1H3
InchiKey	JDNLPKCAXICMBW-UHFFFAOYSA-N
分子式 Formula	C24H23NO
分子量 Molecular Weight	341.45
溶解度Solubility
性狀	Solid powder
儲(chǔ)藏條件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

產(chǎn)品說(shuō)明	JWH-018(CAS:209414-07-3):僅限應(yīng)用于工業(yè)或者科學(xué)研究過(guò)程中非醫(yī)療目的，不應(yīng)用于人類或動(dòng)物的臨床診斷以及治過(guò)程療，該產(chǎn)品非藥用，非食用。
Introduction	JWH-018, or AM-678, is an analgesic chemical from the naphthoylindole family that acts as a full agonist at both the CB1 and CB2 cannabinoid receptors, with some selectivity for CB2. It is discontinued (DEA controlled substance)
Application1
Application2
Application3

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危險(xiǎn)性	Warning
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[1]Thaxton-Weissenfluh A, Alsegiani AS, Abiedalla Y, DeRuiter J, Smith F, Clark CR. Analytical studies on the 2-naphthoyl substituted-1-n-pentylindoles: Regioisomeric synthetic cannabinoids. J Chromatogr B Analyt Technol Biomed Life Sci. 2018 Mar 1;1077-1078:77-84. doi: 10.1016/j.jchromb.2018.01.036. Epub 2018 Jan 3[1]PubMed PMID: 29413581.

[2]Thomas BF, Lefever TW, Cortes RA, Grabenauer M, Kovach AL, Cox AO, Patel PR, Pollard GT, Marusich JA, Kevin RC, Gamage TF, Wiley JL. Thermolytic Degradation of Synthetic Cannabinoids: Chemical Exposures and Pharmacological Consequences. J Pharmacol Exp Ther. 2017 Apr;361(1):162-171. doi: 10.1124/jpet.116.238717. Epub 2017 Jan 13. Erratum in: J Pharmacol Exp Ther. 2017 May;361(2):245. PubMed PMID: 28087785; PubMed Central PMCID: PMC5363769.

[3] Nakayama H, Kenjyou N, Ito Y. Development and Characterization of Monoclonal Antibodies Specific for 3-(1-naphthoyl) Indole Derivatives. Monoclon Antib Immunodiagn Immunother. 2016 Feb;35(1):48-51. doi: 10.1089/mab.2015.0045. Epub 2016 Jan 26. PubMed PMID: 26871514.

[4] Thaxton A, Belal TS, Smith F, DeRuiter J, Abdel-Hay KM, Clark CR. Mass spectral studies on 1-n-pentyl-3-(1-naphthoyl)indole (JWH-018), three deuterium-labeled analogues and the inverse isomer 1-naphthoyl-3-n-pentylindole. Rapid Commun Mass Spectrom. 2015 May 15;29(9):871-7. doi: 10.1002/rcm.7171. PubMed PMID: 26377015.

[5] De Luca MA, Bimpisidis Z, Melis M, Marti M, Caboni P, Valentini V, Margiani G, Pintori N, Polis I, Marsicano G, Parsons LH, Di Chiara G. Stimulation of in vivo dopamine transmission and intravenous self-administration in rats and mice by JWH-018, a Spice cannabinoid. Neuropharmacology. 2015 Dec;99:705-14. doi: 10.1016/j.neuropharm.2015.08.041. Epub 2015 Oct 23. PubMed PMID: 26327678.

6: Wiley JL, Marusich JA, Lefever TW, Antonazzo KR, Wallgren MT, Cortes RA, Patel PR, Grabenauer M, Moore KN, Thomas BF. AB-CHMINACA, AB-PINACA, and FUBIMINA: Affinity and Potency of Novel Synthetic Cannabinoids in Producing Δ9-Tetrahydrocannabinol-Like Effects in Mice. J Pharmacol Exp Ther. 2015 Sep;354(3):328-39. doi: 10.1124/jpet.115.225326. Epub 2015 Jun 23. PubMed PMID: 26105953; PubMed Central PMCID: PMC4538877.7: Thaxton A, Belal TS, Smith F, DeRuiter J, Abdel-Hay KM, Clark CR. GC-MS studies on the six naphthoyl-substituted 1-n-pentyl-indoles: JWH-018 and five regioisomeric equivalents. Forensic Sci Int. 2015 Jul;25

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