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Justicidin A

NMR下載 COA and HPLC MSDS下載
names：
9-(benzo[d][1,3]dioxol-5-yl)-4,6,7-trimethoxynaphtho[2,3-c]furan-1(3H)-one
CAS號：
25001-57-4
MDL Number：
MF(分子式)： C22H18O7 MW(分子量)： 394.37
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文別名	Justicidin A
英文別名	Justicidin A; Justicidins; Justicidin;
CAS號	25001-57-4
Inchi	InChI=1S/C22H18O7/c1-24-16-7-12-13(8-17(16)25-2)21(26-3)14-9-27-22(23)20(14)19(12)11-4-5-15-18(6-11)29-10-28-15/h4-8H,9-10H2,1-3H3
InchiKey	ANFSXHKDCKWWDB-UHFFFAOYSA-N
分子式 Formula	C22H18O7
分子量 Molecular Weight	394.37
溶解度Solubility
性狀	Solid powder
儲藏條件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

產品說明	Justicidin A(CAS:25001-57-4):僅限應用于工業(yè)或者科學研究過程中非醫(yī)療目的，不應用于人類或動物的臨床診斷以及治過程療，該產品非藥用，非食用。
Introduction	Justicidin A is a bioactive chemical isolaed from Justica procumbens.
Application1
Application2
Application3

警示圖
危險性	Warning
危險性警示
安全聲明
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備注

[1]Youm J, Lee H, Choi Y, Yoon J. DW2008S and its major constituents from Justicia procumbens exert anti-asthmatic effect via multitargeting activity. J Cell Mol Med. 2018 May;22(5):2680-269[1]doi: 10.1111/jcmm.13550. Epub 2018 Mar 7. PubMed PMID: 29512870; PubMed Central PMCID: PMC5908124.

[2]Jiang J, Dong H, Wang T, Zhao R, Mu Y, Geng Y, Zheng Z, Wang X. A Strategy for Preparative Separation of 10 Lignans from Justicia procumbens L. by High-Speed Counter-Current Chromatography. Molecules. 2017 Nov 23;22(12). pii: E2024. doi: 10.3390/molecules22122024. PubMed PMID: 29168751.

[3] Youm J, Lee H, Chang HB, Jeon J, Yoon MH, Woo JY, Choi MS, Hwang Y, Seong S, Na K, Yoon J. Justicia procumbens Extract (DW2008) Selectively Suppresses Th2 Cytokines in Splenocytes and Ameliorates Ovalbumin-Induced Airway Inflammation in a Mouse Model of Asthma. Biol Pharm Bull. 2017;40(9):1416-1422. doi: 10.1248/bpb.b17-00179. PubMed PMID: 28867724.

[4] Chun YS, Kim J, Chung S, Khorombi E, Naidoo D, Nthambeleni R, Harding N, Maharaj V, Fouche G, Yang HO. Protective Roles of Monsonia angustifolia and Its Active Compounds in Experimental Models of Alzheimer's Disease. J Agric Food Chem. 2017 Apr 19;65(15):3133-3140. doi: 10.1021/acs.jafc.6b04451. Epub 2017 Apr 5. PubMed PMID: 28378593.

[5] Snyder JC, Rochelle LK, Ray C, Pack TF, Bock CB, Lubkov V, Lyerly HK, Waggoner AS, Barak LS, Caron MG. Inhibiting clathrin-mediated endocytosis of the leucine-rich G protein-coupled receptor-5 diminishes cell fitness. J Biol Chem. 2017 Apr 28;292(17):7208-7222. doi: 10.1074/jbc.M116.756635. Epub 2017 Mar 8. PubMed PMID: 28275053; PubMed Central PMCID: PMC5409487.

6: Luo J, Hu Y, Qin J, Yang M. Ultra high performance liquid chromatography-electrospray ionization-tandem mass spectrometry and pharmacokinetic analysis of justicidin B and 6'-hydroxy justicidin C in rats. J Sep Sci. 2017 Feb;40(3):604-611. doi: 10.1002/jssc.201600961. Epub 2016 Dec 29. PubMed PMID: 27874243.7: Hemmati S, Seradj H. Justicidin B: A Promising Bioactive Lignan. Molecules. 2016 Jun 23;21(7). pii: E820. doi: 10.3390/molecules21070820. Review. PubMed PMID: 27347906.8: Gu MY, Kim J, Yang HO. The Neuroprotective Effects of Justicidin A on Amyloid Beta25-35-Induced Neuronal Cell Death Through Inhibition of Tau Hyperphosphorylation and Induction of Autophagy in SH-SY5Y Cells. Neurochem Res. 2016 Jun;41(6):1458-67. doi: 10.1007/s11064-016-1857-5. Epub 2016 Feb 18. PubMed PMID: 26887582.9: Naresh G, Kant R, Narender T. Silver(I)-Catalyzed Regioselective Construction of Highly Substituted α-Naphthols and Its Application toward Expeditious Synthesis of Lignan Natural Products. Org Lett. 2015 Jul 17;17(14):3446-9. doi: 10.1021/acs.orglett.5b01477. Epub 2015 Jul 9. PubMed PMID: 26158760.10: Kao TT, Lin CC, Shia KS. The Total Synthesis of Retrojusticidin B, Justicidin E, and Helioxanthin. J Org Chem. 2015 Jul 2;80(13):6708-14. doi: 10.1021/acs.joc.5b00866. Epub 2015 Jun 15. PubMed PMID: 26047161.1

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