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JM-244

NMR下載 COA and HPLC MSDS下載
names：
Platinum, amminebis(benzoato-O)dichloro(1-propanamine)-, (OC-6-43)-
CAS號(hào)：
129580-58-1
MDL Number：
MF(分子式)： C17H22Cl2N2O4Pt MW(分子量)： 584.36
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文別名	JM-244
英文別名	JM 244, JM-244, JM244
CAS號(hào)	129580-58-1
Inchi	1S/2C7H6O2.C3H9N.2ClH.H3N.Pt/c28-7(9)6-4-2-1-3-5-6;1-2-3-4;;;;/h21-5H,(H,8,9);2-4H2,1H3;2*1H;1H3;/q;;;;;;+4/p-4
InchiKey	CEIAKSIEJLYWAV-UHFFFAOYSA-J
分子式 Formula	C17H22Cl2N2O4Pt
分子量 Molecular Weight	584.36
溶解度Solubility
性狀	Solid powder
儲(chǔ)藏條件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

產(chǎn)品說明	JM-244(CAS:129580-58-1):僅限應(yīng)用于工業(yè)或者科學(xué)研究過程中非醫(yī)療目的，不應(yīng)用于人類或動(dòng)物的臨床診斷以及治過程療，該產(chǎn)品非藥用，非食用。
Introduction	JM-244amine is a Pt(IV) dicarboxylates that may be useful in the study of carcinoma cell lines. JM-244 slows S-phase transit and blocks G2. Studies show cells die either through apoptosis (largely during S-phase) or by failing to overcome the G2 block (some days after treatment). In G2, the cells either divided or became enlarged and died.
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警示圖
危險(xiǎn)性	Warning
危險(xiǎn)性警示
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[1]Ormerod MG, Orr RM, O'Neill CF, Chwalinski T, Titley JC, Kelland LR, Harrap KR. The cytotoxic action of four ammine/amine platinum(IV) dicarboxylates: a flow cytometric study. Br J Cancer. 1996 Dec;74(12):1935-43. PubMed PMID: 8980393; PubMed Central PMCID: PMC2074815.

[2]Orr RM, O'Neill CF, Nicolson MC, Barnard CF, Murrer BA, Giandomenico CM, Vollano JF, Harrap KR. Evaluation of novel ammine/amine platinum (IV) dicarboxylates in L1210 murine leukaemia cells sensitive and resistant to cisplatin, tetraplatin or carboplatin. Br J Cancer. 1994 Sep;70(3):415-20. PubMed PMID: 8080724; PubMed Central PMCID: PMC2033379.

[3] Kelland LR, Mistry P, Abel G, Loh SY, O'Neill CF, Murrer BA, Harrap KR. Mechanism-related circumvention of acquired cis-diamminedichloroplatinum(II) resistance using two pairs of human ovarian carcinoma cell lines by ammine/amine platinum(IV) dicarboxylates. Cancer Res. 1992 Jul 15;52(14):3857-64. PubMed PMID: 1617660.

[4] Kelland LR, Murrer BA, Abel G, Giandomenico CM, Mistry P, Harrap KR. Ammine/amine platinum(IV) dicarboxylates: a novel class of platinum complex exhibiting selective cytotoxicity to intrinsically cisplatin-resistant human ovarian carcinoma cell lines. Cancer Res. 1992 Feb 15;52(4):822-8. PubMed PMID: 1737343.

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