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Javanicin

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names：
5,8-dihydroxy-6-methoxy-2-methyl-3-(2-oxopropyl)naphthalene-1,4-dione
CAS號(hào)：
476-45-9
MDL Number：
MF(分子式)： C15H14O6 MW(分子量)： 290.27
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文別名	Javanicin
英文別名	Javanicin; HSDB 3501; HSDB-3501; HSDB3501; BRN 2296055; Javanicin (Fusarium);
CAS號(hào)	476-45-9
Inchi	InChI=1S/C15H14O6/c1-6(16)4-8-7(2)13(18)11-9(17)5-10(21-3)15(20)12(11)14(8)19/h5,17,20H,4H2,1-3H3
InchiKey	UWONIGLSEZRPGH-UHFFFAOYSA-N
分子式 Formula	C15H14O6
分子量 Molecular Weight	290.27
溶解度Solubility
性狀	Solid powder
儲(chǔ)藏條件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

產(chǎn)品說(shuō)明	Javanicin(CAS:476-45-9):僅限應(yīng)用于工業(yè)或者科學(xué)研究過(guò)程中非醫(yī)療目的，不應(yīng)用于人類(lèi)或動(dòng)物的臨床診斷以及治過(guò)程療，該產(chǎn)品非藥用，非食用。
Introduction	Javanicin is an Antibacterial Naphthaquinone from an Endophytic Fungus of Neem, Chloridium sp.
Application1
Application2
Application3

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危險(xiǎn)性	Warning
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[1]Kehelpannala C, Kumar NS, Jayasinghe L, Araya H, Fujimoto Y. Naphthoquinone Metabolites Produced by Monacrosporium ambrosium, the Ectosymbiotic Fungus of Tea Shot-Hole Borer, Euwallacea fornicatus, in Stems of Tea, Camellia sinensis. J Chem Ecol. 2018 Jan;44(1):95-10[1]doi: 10.1007/s10886-017-0913-[1]Epub 2018 Jan 2. PubMed PMID: 29292470.

[2]Shah A, Rather MA, Hassan QP, Aga MA, Mushtaq S, Shah AM, Hussain A, Baba SA, Ahmad Z. Discovery of anti-microbial and anti-tubercular molecules from Fusarium solani: an endophyte of Glycyrrhiza glabra. J Appl Microbiol. 2017 May;122(5):1168-1176. doi: 10.1111/jam.13410. Epub 2017 Apr 4. PubMed PMID: 28150900.

[3] Win NN, Ito T, Win YY, Ngwe H, Kodama T, Abe I, Morita H. Quassinoids: Viral protein R inhibitors from Picrasma javanica bark collected in Myanmar for HIV infection. Bioorg Med Chem Lett. 2016 Oct 1;26(19):4620-4624. doi: 10.1016/j.bmcl.2016.08.055. Epub 2016 Aug 21. PubMed PMID: 27575477.

[4] Alvin A, Kalaitzis JA, Sasia B, Neilan BA. Combined genetic and bioactivity-based prioritization leads to the isolation of an endophyte-derived antimycobacterial compound. J Appl Microbiol. 2016 May;120(5):1229-39. doi: 10.1111/jam.13062. Epub 2016 Apr 4. PubMed PMID: 26785029.

[5] Takemoto K, Kamisuki S, Chia PT, Kuriyama I, Mizushina Y, Sugawara F. Bioactive dihydronaphthoquinone derivatives from Fusarium solani. J Nat Prod. 2014 Sep 26;77(9):1992-6. doi: 10.1021/np500175j. Epub 2014 Aug 28. PubMed PMID: 25163667.

6: Hashimoto J, Motohashi K, Sakamoto K, Hashimoto S, Yamanouchi M, Tanaka H, Takahashi T, Takagi M, Shin-ya K. Screening and evaluation of new inhibitors of hepatic glucose production. J Antibiot (Tokyo). 2009 Nov;62(11):625-9. doi: 10.1038/ja.2009.93. Epub 2009 Sep 25. PubMed PMID: 19779500.7: Kharwar RN, Verma VC, Kumar A, Gond SK, Harper JK, Hess WM, Lobkovosky E, Ma C, Ren Y, Strobel GA. Javanicin, an antibacterial naphthaquinone from an endophytic fungus of neem, Chloridium sp. Curr Microbiol. 2009 Mar;58(3):233-8. doi: 10.1007/s00284-008-9313-7. Epub 2008 Nov 19. PubMed PMID: 19018591.8: Medentsev AG, Arinbasarova AIu, Akimenko VK. [Biosynthesis of naphthoquinone pigments by fungi of the genus Fusarium]. Prikl Biokhim Mikrobiol. 2005 Sep-Oct;41(5):573-7. Russian. PubMed PMID: 16240659.9: Bironaité DA, Cénas NK, Anusevicius ZJ, Medentsev AG, Akimenko VK, Usanov SA. Fungal quinone pigments as oxidizers and inhibitors of mitochondrial NADH:ubiquinone reductase. Arch Biochem Biophys. 1992 Sep;297(2):253-7. PubMed PMID: 1497345.10: Ohmoto T, Koike K, Mitsunaga K, Fukuda H, Kagei K. Studies on the constituents of Indonesian Picrasma javanica. III. Structures of new quassinoids, javanicins A, C and D. Chem Pharm Bull (Tokyo). 1989 Nov;37(11):2991-4. PubMed PMID: 2632044.1

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