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Hyperforin-DCHA

NMR下載 COA and HPLC MSDS下載
names：
(1R,5R,7S,8R)-4-hydroxy-1-isobutyryl-8-methyl-3,5,7-tris(3-methylbut-2-en-1-yl)-8-(4-methylpent-3-en-1-yl)bicyclo[3.3.1]non-3-ene-2,9-dione compound with dicyclohexylamine (11)
CAS號：
238074-03-8
MDL Number：
MF(分子式)： C47H75NO4 MW(分子量)： 718.12
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文別名	Hyperforin-DCHA
英文別名	RT-013293; RT013293; RT 013293; J-015220; J015220; J 015220; Hyperforin-DCHA, Hyperforin Dicyclohexylammonium
CAS號	238074-03-8
Inchi	InChI=1S/C35H52O4.C12H23N/c1-22(2)13-12-19-33(11)27(16-14-23(3)4)21-34(20-18-25(7)8)30(37)28(17-15-24(5)6)31(38)35(33,32(34)39)29(36)26(9)10;1-3-7-11(8-4-1)13-12-9-5-2-6-10-12/h13-15,18,26-27,37H,12,16-17,19-21H2,1-11H3;11-13H,1-10H2/t27-,33+,34+,35-;/m0./s1
InchiKey	KJVNMVCMFQAPDM-DNSWOBEMSA-N
分子式 Formula	C47H75NO4
分子量 Molecular Weight	718.12
溶解度Solubility
性狀	White to off-white solid powder
儲藏條件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

產(chǎn)品說明	Hyperforin-DCHA(CAS:238074-03-8):僅限應(yīng)用于工業(yè)或者科學(xué)研究過程中非醫(yī)療目的，不應(yīng)用于人類或動物的臨床診斷以及治過程療，該產(chǎn)品非藥用，非食用。
Introduction	Hyperforin-DCHA, also known as Hyperforin Dicyclohexylammonium, is a stable salt form of hyperforin, a compound found in Hypericum perforatum. It induces cell cycle arrest and apoptosis in chronic myelogenous leukemia cells, prevents LPS- and substance P-induced release of IL-6 in astrocytoma cells, and suppresses the development of croton oil-induced edema.
Application1
Application2
Application3

警示圖
危險性	Warning
危險性警示
安全聲明
安全防護(hù)
備注

[1]Liu JY, Liu Z, Wang DM, Li MM, Wang SX, Wang R, Chen JP, Wang YF, Yang DP. Induction of apoptosis in K562 cells by dicyclohexylammonium salt of hyperforin through a mitochondrial-related pathway. Chem Biol Interact. 2011 Apr 25;190(2-3):91-10[1]doi: 10.1016/j.cbi.2011.02.026. Epub 2011 Mar 3. PubMed PMID: 21376709.

[2]Cervo L, Rozio M, Ekalle-Soppo CB, Guiso G, Morazzoni P, Caccia S. Role of hyperforin in the antidepressant-like activity of Hypericum perforatum extracts. Psychopharmacology (Berl). 2002 Dec;164(4):423-8. Epub 2002 Sep 24. PubMed PMID: 12457273.

[3] Gaid M, Haas P, Beuerle T, Scholl S, Beerhues L. Hyperforin production in Hypericum perforatum root cultures. J Biotechnol. 2016 Mar 20;22

2:47-55. doi: 10.1016/j.jbiotec.2016.02.016. Epub 2016 Feb 10. PubMed PMID: 26876610.

[5] Cervo L, Mennini T, Rozio M, Ekalle-Soppo CB, Canetta A, Burbassi S, Guiso G, Pirona L, Riva A, Morazzoni P, Caccia S, Gobbi M. Potential antidepressant properties of IDN 5491 (hyperforin-trimethoxybenzoate), a semisynthetic ester of hyperforin. Eur Neuropsychopharmacol. 2005 Mar;15(2):211-8. PubMed PMID: 15695067.

5: Sosa S, Pace R, Bornancin A, Morazzoni P, Riva A, Tubaro A, Della Loggia R. Topical anti-inflammatory activity of extracts and compounds from Hypericum perforatum L. J Pharm Pharmacol. 2007 May;59(5):703-9. PubMed PMID: 17524236.

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