購(gòu)物車(chē) 
-
Grifolin
- names：
5,7,11-Tridecatriene-3,4-diol, 3,8,12-trimethyl-
- CAS號(hào)：
6379-55-1
MDL Number： - MF(分子式)： C16H28O2 MW(分子量)： 252.398
- EINECS: Reaxys Number:
- Pubchem ID: Brand:BIOFOUNT
| 貨品編碼 | 規(guī)格 | 純度 | 價(jià)格 (￥) | 現(xiàn)價(jià)(￥) | 特價(jià)(￥) | 庫(kù)存描述 | 數(shù)量 | 總計(jì) (￥) |
|---|
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| 中文別名 | Grifolin |
| 英文別名 | Grifolin; BRN 1782428 |
| CAS號(hào) | 6379-55-1 |
| Inchi | InChI=1S/C16H28O2/c1-6-16(5,18)15(17)12-8-11-14(4)10-7-9-13(2)3/h8-9,11-12,15,17-18H,6-7,10H2,1-5H3/b12-8+,14-11+ |
| InchiKey | LYXITZQJPFABBF-ZZAMHKPASA-N |
| 分子式 Formula | C16H28O2 |
| 分子量 Molecular Weight | 252.398 |
| 溶解度Solubility | |
| 性狀 | Solid powder |
| 儲(chǔ)藏條件 Storage conditions | Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years). |
| 產(chǎn)品說(shuō)明 | Grifolin(CAS:6379-55-1):僅限應(yīng)用于工業(yè)或者科學(xué)研究過(guò)程中非醫(yī)療目的，不應(yīng)用于人類(lèi)或動(dòng)物的臨床診斷以及治過(guò)程療，該產(chǎn)品非藥用，非食用。 |
| Introduction | Grifolin is a secondary metabolite isolated from the fresh fruiting bodies of the mushroom Albatrellus confluens that has been shown to inhibit the growth of some cancer cell lines in vitro by induction of apoptosis via targeting DAPK1. |
| Application1 | |
| Application2 | |
| Application3 |
| [1]Luo XJ, Li LL, Deng QP, Yu XF, Yang LF, Luo FJ, Xiao LB, Chen XY, Ye M, Liu JK, Cao Y. Grifolin, a potent antitumour natural product upregulates death-associated protein kinase 1 DAPK1 via p53 in nasopharyngeal carcinoma cells. Eur J Cancer. 2011 Jan;47(2):316-25. doi: 10.1016/j.ejca.2010.09.02[1]Epub 2010 Oct 1[1]PubMed PMID: 20943371. |
| [2]Luo X, Yu X, Liu S, Deng Q, Liu X, Peng S, Li H, Liu J, Cao Y. The role of targeting kinase activity by natural products in cancer chemoprevention and chemotherapy (Review). Oncol Rep. 2015 Aug;34(2):547-54. doi: 10.3892/or.2015.4029. Epub 2015 Jun 4. Review. PubMed PMID: 26044950. |
| [3] Liu LY, Li ZH, Ding ZH, Dong ZJ, Li GT, Li Y, Liu JK. Meroterpenoid pigments from the basidiomycete Albatrellus ovinus. J Nat Prod. 2013 Jan 25;76(1):79-84. doi: 10.1021/np300751m. Epub 2013 Jan 10. PubMed PMID: 23305465. |
| [4] Luo XJ, Li W, Yang LF, Yu XF, Xiao LB, Tang M, Dong X, Deng QP, Bode AM, Liu JK, Cao Y. DAPK1 mediates the G1 phase arrest in human nasopharyngeal carcinoma cells induced by grifolin, a potential antitumor natural product. Eur J Pharmacol. 2011 Nov 30;670(2-3):427-34. doi: 10.1016/j.ejphar.2011.08.026. Epub 2011 Sep 6. PubMed PMID: 21914449. |
| [5] Song J, Manir MM, Moon SS. Cytotoxic grifolin derivatives isolated from the wild mushroom Boletus pseudocalopus (Basidiomycetes). Chem Biodivers. 2009 Sep;6(9):1435-42. doi: 10.1002/cbdv.200800217. PubMed PMID: 19774605. |
6: HIRATA Y, NAKANISHI K. Grifolin, an antibiotic from a basidiomycete. J Biol Chem. 1950 May;184(1):135-43. PubMed PMID: 15421982.7: Liu LY, Li ZH, Wang GQ, Wei K, Dong ZJ, Feng T, Li GT, Li Y, Liu JK. Nine new farnesylphenols from the basidiomycete albatrellus caeruleoporus. Nat Prod Bioprospect. 2014 Apr;4(2):119-28. doi: 10.1007/s13659-014-0015-5. Epub 2014 Apr 23. PubMed PMID: 24858140; PubMed Central PMCID: PMC4004861.8: Luo X, Yang L, Xiao L, Xia X, Dong X, Zhong J, Liu Y, Li N, Chen L, Li H, Li W, Liu W, Yu X, Chen H, Tang M, Weng X, Yi W, Bode A, Dong Z, Liu J, Cao Y. Grifolin directly targets ERK1/2 to epigenetically suppress cancer cell metastasis. Oncotarget. 2015 Dec 15;6(40):42704-16. doi: 10.18632/oncotarget.5678. PubMed PMID: 26516701; PubMed Central PMCID: PMC4767464.9: Alves MJ, Ferreira IC, Dias J, Teixeira V, Martins A, Pintado M. A review on antifungal activity of mushroom (basidiomycetes) extracts and isolated compounds. Curr Top Med Chem. 2013;13(21):2648-59. Review. PubMed PMID: 24083794.10: Quang DN, Hashimoto T, Arakawa Y, Kohchi C, Nishizawa T, Soma G, Asakawa Y. Grifolin derivatives from Albatrellus caeruleoporus, new inhibitors of nitric oxide production in RAW 264.7 cells. Bioorg Med Chem. 2006 Jan 1;14(1):164-8. Epub 2005 Sep 16. PubMed PMID: 16169234.1
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