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GL-331

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names：
(5R,5aR,8aS,9S)-5-(4-hydroxy-3,5-dimethoxyphenyl)-9-((4-nitrophenyl)amino)-5,8,8a,9-tetrahydrofuro[3',4'6,7]naphtho[2,3-d][1,3]dioxol-6(5aH)-one
CAS號(hào)：
127882-73-9
MDL Number：
MF(分子式)： C27H24N2O9 MW(分子量)： 520.49
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文別名	GL-331
英文別名	GL-331; W-68; GL331; W68; GL 331; W 68
CAS號(hào)	127882-73-9
Inchi	InChI=1S/C27H24N2O9/c1-34-21-7-13(8-22(35-2)26(21)30)23-16-9-19-20(38-12-37-19)10-17(16)25(18-11-36-27(31)24(18)23)28-14-3-5-15(6-4-14)29(32)33/h3-10,18,23-25,28,30H,11-12H2,1-2H3/t18-,23+,24-,25+/m0/s1
InchiKey	DLROLUIVVKTFPW-LVEBQJTPSA-N
分子式 Formula	C27H24N2O9
分子量 Molecular Weight	520.49
溶解度Solubility
性狀	Solid powder
儲(chǔ)藏條件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

產(chǎn)品說明	GL-331(CAS:127882-73-9):僅限應(yīng)用于工業(yè)或者科學(xué)研究過程中非醫(yī)療目的，不應(yīng)用于人類或動(dòng)物的臨床診斷以及治過程療，該產(chǎn)品非藥用，非食用。
Introduction	GL-331, also known as W-68, is a DNA topoisomerase II inhibitor potentially for the treatment of small cell lung cancer and gastric cancer.
Application1
Application2
Application3

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[1]Wang YJ, Chen XG, Xiao ZY, Liu GT, Sun H. Induction of cell cycle arrest by GL331 via triggering an ATM-dependent DNA damage response in HepG2 cells. J Asian Nat Prod Res. 2012;14(7):657-64. doi: 10.1080/10286020.2012.684683. Epub 2012 May 15. PubMed PMID: 22583615.

[2]Lee CC, Huang TS. A novel topoisomerase II poison GL331 preferentially induces DNA cleavage at (C/G)T sites and can cause telomere DNA damage. Pharm Res. 2001 Jun;18(6):846-51. PubMed PMID: 11474790.

[3] Huang TS, Lee CC, Chao Y, Shu CH, Chen LT, Chen LL, Chen MH, Yuan CC, Whang-Peng J. A novel podophyllotoxin-derived compound GL331 is more potent than its congener VP-16 in killing refractory cancer cells. Pharm Res. 1999 Jul;16(7):997-1002. PubMed PMID: 10450922.

[4] Chen Y, Su YH, Wang CH, Wu JM, Chen JC, Tseng SH. Induction of apoptosis and cell cycle arrest in glioma cells by GL331 (a topoisomerase II inhibitor). Anticancer Res. 2005 Nov-Dec;25(6B):4203-8. PubMed PMID: 16309217.

[5] Huang TS, Lee CC, Chang AC, Lin S, Chao CC, Jou YS, Chu YW, Wu CW, Whang-Peng J. Shortening of microsatellite deoxy(CA) repeats involved in GL331-induced down-regulation of matrix metalloproteinase-9 gene expression. Biochem Biophys Res Commun. 2003 Jan 24;300(4):901-7. PubMed PMID: 12559958.

6: Huang TS, Shu CH, Lee CC, Chen LT, Whang-Peng J. In vitro evaluation of GL331's cancer cell killing and apoptosis-inducing activity in combination with other chemotherapeutic agents. Apoptosis. 2000 Feb;5(1):79-85. PubMed PMID: 11227495.7: Chang H, Shyu KG, Lee CC, Tsai SC, Wang BW, Hsien Lee Y, Lin S. GL331 inhibits HIF-1alpha expression in a lung cancer model. Biochem Biophys Res Commun. 2003 Feb 28;302(1):95-100. PubMed PMID: 12593853.8: Huang TS, Shu CH, Yang WK, Whang-Peng J. Activation of CDC 25 phosphatase and CDC 2 kinase involved in GL331-induced apoptosis. Cancer Res. 1997 Jul 15;57(14):2974-8. PubMed PMID: 9230211.9: Kuo ML, Shen SC, Yang CH, Chuang SE, Cheng AL, Huang TS. Bcl-2 prevents topoisomerase II inhibitor GL331-induced apoptosis is mediated by down-regulation of poly(ADP-ribose)polymerase activity. Oncogene. 1998 Oct 29;17(17):2225-34. PubMed PMID: 9811453.10: Liu JM, Chen LT, Chao Y, Li AF, Wu CW, Liu TS, Shiah HS, Chang JY, Chen JD, Wu HW, Lin WC, Lan C, Whang-Peng J. Phase II and pharmacokinetic study of GL331 in previously treated Chinese gastric cancer patients. Cancer Chemother Pharmacol. 2002 May;49(5):425-8. Epub 2002 Mar 8. PubMed PMID: 11976838.1

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