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Ganoderiol A

NMR下載 COA and HPLC MSDS下載
names：
(3S,6R)-6-((3S,5R,10S,13R,14R,17R)-3-hydroxy-4,4,10,13,14-pentamethyl-2,3,4,5,6,10,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl)-2-methylheptane-1,2,3-triol
CAS號(hào)：
106518-61-0
MDL Number：
MF(分子式)： C30H50O4 MW(分子量)： 474.72
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文別名	Ganoderiol A
英文別名	Ganoderiol A; Ganoderiol A, (+)-; (+)-Ganoderiol A;
CAS號(hào)	106518-61-0
Inchi	InChI=1S/C30H50O4/c1-19(8-11-25(33)30(7,34)18-31)20-12-16-29(6)22-9-10-23-26(2,3)24(32)14-15-27(23,4)21(22)13-17-28(20,29)5/h9,13,19-20,23-25,31-34H,8,10-12,14-18H2,1-7H3/t19-,20-,23+,24+,25+,27-,28-,29+,30?/m1/s1
InchiKey	VMEFPSOTFFVAQJ-OBGNTNONSA-N
分子式 Formula	C30H50O4
分子量 Molecular Weight	474.72
溶解度Solubility
性狀	Solid powder
儲(chǔ)藏條件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

產(chǎn)品說明	Ganoderiol A(CAS:106518-61-0):僅限應(yīng)用于工業(yè)或者科學(xué)研究過程中非醫(yī)療目的，不應(yīng)用于人類或動(dòng)物的臨床診斷以及治過程療，該產(chǎn)品非藥用，非食用。
Introduction	Ganoderiol A is a tetracyclic triterpene isolated from Ganoderma amboinense.
Application1
Application2
Application3

警示圖
危險(xiǎn)性	Warning
危險(xiǎn)性警示
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[1]Wu GS, Song YL, Yin ZQ, Guo JJ, Wang SP, Zhao WW, Chen XP, Zhang QW, Lu JJ, Wang YT. Ganoderiol A-enriched extract suppresses migration and adhesion of MDA-MB-231 cells by inhibiting FAK-SRC-paxillin cascade pathway. PLoS One. 2013 Oct 29;8(10):e76620. doi: 10.1371/journal.pone.0076620. eCollection 2013. PubMed PMID: 24204647; PubMed Central PMCID: PMC3812178.

[2]Chang UM, Li CH, Lin LI, Huang CP, Kan LS, Lin SB. Ganoderiol F, a ganoderma triterpene, induces senescence in hepatoma HepG2 cells. Life Sci. 2006 Aug 15;79(12):1129-39. Epub 2006 Mar 28. PubMed PMID: 16635496.

[3] Liu JQ, Wang CF, Li Y, Luo HR, Qiu MH. Isolation and bioactivity evaluation of terpenoids from the medicinal fungus Ganoderma sinense. Planta Med. 2012 Mar;78(4):368-76. doi: 10.1055/s-0031-1280441. Epub 2011 Dec 12. PubMed PMID: 22161763.

[4] Zhang Q, Zuo F, Nakamura N, Ma CM, Hattori M. Metabolism and pharmacokinetics in rats of ganoderiol F, a highly cytotoxic and antitumor triterpene from Ganoderma lucidum. J Nat Med. 2009 Jul;63(3):304-10. doi: 10.1007/s11418-009-0337-5. Epub 2009 May 1. PubMed PMID: 19407927.

[5] el-Mekkawy S, Meselhy MR, Nakamura N, Tezuka Y, Hattori M, Kakiuchi N, Shimotohno K, Kawahata T, Otake T. Anti-HIV-1 and anti-HIV-1-protease substances from Ganoderma lucidum. Phytochemistry. 1998 Nov;49(6):1651-7. PubMed PMID: 9862140.

6: Sato N, Ma CM, Komatsu K, Hattori M. Triterpene-farnesyl hydroquinone conjugates from Ganoderma sinense. J Nat Prod. 2009 May 22;72(5):958-61. doi: 10.1021/np800687t. PubMed PMID: 19331378.7: Choi S, Nguyen VT, Tae N, Lee S, Ryoo S, Min BS, Lee JH. Anti-inflammatory and heme oxygenase-1 inducing activities of lanostane triterpenes isolated from mushroom Ganoderma lucidum in RAW264.7 cells. Toxicol Appl Pharmacol. 2014 Nov 1;280(3):434-42. doi: 10.1016/j.taap.2014.09.007. Epub 2014 Sep 16. PubMed PMID: 25239868.8: Qiao Y, Zhang XM, Qiu MH. Two novel lanostane triterpenoids from Ganoderma sinense. Molecules. 2007 Aug 23;12(8):2038-46. PubMed PMID: 17960104.9: Grienke U, Mihály-Bison J, Schuster D, Afonyushkin T, Binder M, Guan SH, Cheng CR, Wolber G, Stuppner H, Guo DA, Bochkov VN, Rollinger JM. Pharmacophore-based discovery of FXR-agonists. Part II: identification of bioactive triterpenes from Ganoderma lucidum. Bioorg Med Chem. 2011 Nov 15;19(22):6779-91. doi: 10.1016/j.bmc.2011.09.039. Epub 2011 Sep 29. PubMed PMID: 22014750; PubMed Central PMCID: PMC3254236.10: Zhang SS, Ma QY, Huang SZ, Dai HF, Guo ZK, Yu ZF, Zhao YX. Lanostanoids with acetylcholinesterase inhibitory activity from the mushroom Haddowia longipes. Phytochemistry. 2015 Feb;110:133-9. doi: 10.1016/j.phytochem.2014.12.012. Epub 2015 Jan 7. PubMed PMID: 25577284.1

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