購物車 
-
Furegrelate
- names：
sodium;5-(pyridin-3-ylmethyl)-1-benzofuran-2-carboxylate
- CAS號：
85666-17-7
MDL Number： - MF(分子式)： C15H10NNaO3 MW(分子量)： 275.2388
- EINECS: Reaxys Number:
- Pubchem ID: Brand:BIOFOUNT
| 貨品編碼 | 規(guī)格 | 純度 | 價格 (￥) | 現(xiàn)價(￥) | 特價(￥) | 庫存描述 | 數(shù)量 | 總計 (￥) |
|---|
| 中文別名 | Furegrelate |
| 英文別名 | Furegrelate; U 63557A; U-63557A; U63557A |
| CAS號 | 85666-17-7 |
| Inchi | InChI=1S/C15H11NO3.Na/c17-15(18)14-8-12-7-10(3-4-13(12)19-14)6-11-2-1-5-16-9-11;/h1-5,7-9H,6H2,(H,17,18);/q;+1/p-1 |
| InchiKey | XBTIPIZROJAKOJ-UHFFFAOYSA-M |
| 分子式 Formula | C15H10NNaO3 |
| 分子量 Molecular Weight | 275.2388 |
| 溶解度Solubility | |
| 性狀 | Solid powder |
| 儲藏條件 Storage conditions | Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years). |
| 產(chǎn)品說明 | Furegrelate(CAS:85666-17-7):僅限應(yīng)用于工業(yè)或者科學(xué)研究過程中非醫(yī)療目的，不應(yīng)用于人類或動物的臨床診斷以及治過程療，該產(chǎn)品非藥用，非食用。 |
| Introduction | Furegrelate is a thromboxane synthase inhibitor that attenuates the renal vasoconstriction of angiotensin II, presumably by enhancing the formation of vasodilator prostaglandins. |
| Application1 | |
| Application2 | |
| Application3 |
| [1]Hirenallur-S DK, Detweiler ND, Haworth ST, Leming JT, Gordon JB, Rusch NJ. Furegrelate, a thromboxane synthase inhibitor, blunts the development of pulmonary arterial hypertension in neonatal piglets. Pulm Circ. 2012 Apr-Jun;2(2):193-200. doi: 10.4103/2045-8932.97605. PubMed PMID: 22837860; PubMed Central PMCID: PMC3401873. |
| [2]Pestel S, Nath A, Jungermann K, Schieferdecker HL. Inhibition of prostaglandin D2 clearance in rat hepatocytes by the thromboxane receptor antagonists daltroban and ifetroban and the thromboxane synthase inhibitor furegrelate. Biochem Pharmacol. 2003 Aug 15;66(4):643-52. PubMed PMID: 12906929. |
| [3] Kaushal RD, Wilson TW. Effect of furegrelate on renal plasma flow after angiotensin II infusion. Can J Physiol Pharmacol. 1990 Apr;68(4):500-4. PubMed PMID: 2328452. |
| [4] Martorell A, Sagredo A, Aras-López R, Balfagón G, Ferrer M. Ovariectomy increases the formation of prostanoids and modulates their role in acetylcholine-induced relaxation and nitric oxide release in the rat aorta. Cardiovasc Res. 2009 Nov 1;84(2):300-8. doi: 10.1093/cvr/cvp214. Epub 2009 Jun 30. PubMed PMID: 19567483. |
| [5] Mohrland JS, Vander Lugt JT, Lakings DB. Multiple dose trial of the thromboxane synthase inhibitor furegrelate in normal subjects. Eur J Clin Pharmacol. 1990;38(5):485-8. PubMed PMID: 2379533. |
6: Mohrland JS, Vander Lugt JT, Gorman RR, Lakings DB. Thromboxane synthase activity and platelet function after furegrelate administration in man. J Clin Pharmacol. 1989 Jan;29(1):53-8. PubMed PMID: 2708549.7: Payne JE, Langsfeld M, Joseph M, Huber D, Gray-Weale A, Meyer JH, Smith T, Lusby RJ. Effects of Furegrelate (Upjohn 63557A) on patency and platelet deposition after canine carotid endarterectomy. Aust N Z J Surg. 1991 Aug;61(8):619-25. PubMed PMID: 1867616.8: Addison MP, Singh TU, Parida S, Choudhury S, Kasa JK, Sukumaran SV, Darzi SA, Kandasamy K, Singh V, Kumar D, Mishra SK. NO synthase inhibition attenuates EDHF-mediated relaxation induced by TRPV4 channel agonist GSK1016790A in the rat pulmonary artery: Role of TxA2. Pharmacol Rep. 2016 Jun;68(3):620-6. doi: 10.1016/j.pharep.2016.01.003. Epub 2016 Jan 19. PubMed PMID: 26991376.9: Xavier FE, Blanco-Rivero J, Sastre E, Badimón L, Balfagón G. Simultaneous inhibition of TXA(2) and PGI(2) synthesis increases NO release in mesenteric resistance arteries from cirrhotic rats. Clin Sci (Lond). 2010 Jun 25;119(7):283-92. doi: 10.1042/CS20090536. PubMed PMID: 20459396.10: Wilson TW, Badahman AH, Kaushal RD. Thromboxane synthase inhibition enhances furosemide-induced renal vasodilation. Clin Invest Med. 1993 Oct;16(5):372-8. PubMed PMID: 8261690.1
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