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Epirizole

NMR下載 COA and HPLC MSDS下載
names：
4-methoxy-2-(5-methoxy-3-methyl-1H-pyrazol-1-yl)-6-methylpyrimidine
CAS號：
18694-40-1
MDL Number：
MF(分子式)： C11H14N4O2 MW(分子量)： 234.259
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文別名	Epirizole
英文別名	Epirizole; DA-398; DA398; DA 398; Methopyrimazole; Dalex; Mebron;
CAS號	18694-40-1
Inchi	InChI=1S/C11H14N4O2/c1-7-5-9(16-3)13-11(12-7)15-10(17-4)6-8(2)14-15/h5-6H,1-4H3
InchiKey	RHAXSHUQNIEUEY-UHFFFAOYSA-N
分子式 Formula	C11H14N4O2
分子量 Molecular Weight	234.259
溶解度Solubility
性狀	Solid powder
儲藏條件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

產(chǎn)品說明	Epirizole(CAS:18694-40-1):僅限應(yīng)用于工業(yè)或者科學(xué)研究過程中非醫(yī)療目的，不應(yīng)用于人類或動(dòng)物的臨床診斷以及治過程療，該產(chǎn)品非藥用，非食用。
Introduction	Epirizole, also known as DA-398, is a pyrimidinyl pyrazole with antipyretic, analgesic, and anti-inflammatory activity.
Application1
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危險(xiǎn)性	Warning
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[1]Kawashima Y, Lin SY, Ogawa M, Handa T, Takenaka H. Preparations of agglomerated crystals of polymorphic mixtures and a new complex of indomethacin-epirizole by the spherical crystallization technique. J Pharm Sci. 1985 Nov;74(11):1152-6. PubMed PMID: 4087173.

[2]Khomenko T, Deng X, Ahluwalia A, Tarnawski A, Patel KN, Sandor Z, Szabo S. STAT3 and importins are novel mediators of early molecular and cellular responses in experimental duodenal ulceration. Dig Dis Sci. 2014 Feb;59(2):297-306. doi: 10.1007/s10620-013-2807-6. Epub 2014 Jan 3. PubMed PMID: 24385009.

[3] Gallo M, La Montagna G. [Controlled research on the use of epirizole in the therapy of rheumatoid arthritis]. Clin Ter. 1983 Sep 30;106(6):429-33. Italian. PubMed PMID: 6357595.

[4] Rovira M, Huang W, Yusuff S, Shim JS, Ferrante AA, Liu JO, Parsons MJ. Chemical screen identifies FDA-approved drugs and target pathways that induce precocious pancreatic endocrine differentiation. Proc Natl Acad Sci U S A. 2011 Nov 29;108(48):19264-9. doi: 10.1073/pnas.1113081108. Epub 2011 Nov 14. PubMed PMID: 22084084; PubMed Central PMCID: PMC3228434.

[5] Ueshima K, Takeuchi K, Ohuchi T, Okabe S. Acid secretory and duodenal ulcerogenic responses induced by mepirizole in anesthetized rats. Relation to body temperature. Dig Dis Sci. 1994 Aug;39(8):1625-32. PubMed PMID: 7914158.

6: Okabe S, Ishihara Y, Inoo H, Tanaka H. Mepirizole-induced duodenal ulcers in rats and their pathogenesis. Dig Dis Sci. 1982 Mar;27(3):242-9. PubMed PMID: 6122549.7: Tabata K, Jacobson ED, Chen MH, Murphy RF, Joffe SN. Decrease in alkaline secretion during duodenal ulceration induced by mepirizole in rats. Gastroenterology. 1984 Aug;87(2):396-401. PubMed PMID: 6735082.8: Tanaka Y, Sano M. Analytical studies on mepirizole and its metabolites. II. Identification of the human urinary metabolites of mepirizole with stable isotope labeling. Chem Pharm Bull (Tokyo). 1976 Apr;24(4):804-7. PubMed PMID: 949819.9: Sano M, Tanaka Y. Analytical studies on mepirizole and its metabolites. I. Mass spectra of mepirizole and its some metabolites. Chem Pharm Bull (Tokyo). 1975 Jan;23(1):209-16. PubMed PMID: 1164778.10: Onoa GB, Moreno V. Study of the modifications caused by cisplatin, transplatin, and Pd(II) and Pt(II) mepirizole derivatives on pBR322 DNA by atomic force microscopy. Int J Pharm. 2002 Oct 1;245(1-2):55-65. PubMed PMID: 12270242.1

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