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EM-800

NMR下載 COA and HPLC MSDS下載
names：
2,2-Dimethyl-propionic acid 3-[4-(2,2-dimethyl-propionyloxy)-phenyl]-4-methyl-2(S)-[4-(2-piperidin- 1-yl-ethoxy)-phenyl]-2H-chromen-7-yl ester
CAS號：
182167-03-9
MDL Number：
MF(分子式)： C39H47NO6 MW(分子量)： 625.81
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文別名	EM-800
英文別名	EM-800; EM 800; EM800;
CAS號	182167-03-9
Inchi	InChI=1S/C39H47NO6/c1-26-32-20-19-31(45-37(42)39(5,6)7)25-33(32)46-35(34(26)27-11-17-30(18-12-27)44-36(41)38(2,3)4)28-13-15-29(16-14-28)43-24-23-40-21-9-8-10-22-40/h11-20,25,35H,8-10,21-24H2,1-7H3/t35-/m0/s1
InchiKey	OEKMGABCSLYWOP-DHUJRADRSA-N
分子式 Formula	C39H47NO6
分子量 Molecular Weight	625.81
溶解度Solubility
性狀	Solid powder
儲藏條件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

產品說明	EM-800(CAS:182167-03-9):僅限應用于工業(yè)或者科學研究過程中非醫(yī)療目的，不應用于人類或動物的臨床診斷以及治過程療，該產品非藥用，非食用。
Introduction	EM-800 is a high affinity ligand for estrogen receptor-α (ERα), the prodrug of EM-652. EM-800 independently suppressed the growth of E1-stimulated ZR-75-1 xenograft tumors in nude mice.
Application1
Application2
Application3

警示圖
危險性	Warning
危險性警示
安全聲明
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備注

[1]Couillard S, Labrie C, Bélanger A, Candas B, Pouliot F, Labrie F. Effect of dehydroepiandrosterone and the antiestrogen EM-800 on growth of human ZR-75-1 breast cancer xenografts. J Natl Cancer Inst. 1998 May 20;90(10):772-8. PubMed PMID: 9605648.

[2]Sourla A, Luo S, Labrie C, Bélanger A, Labrie F. Morphological changes induced by 6-month treatment of intact and ovariectomized mice with tamoxifen and the pure antiestrogen EM-800. Endocrinology. 1997 Dec;138(12):5605-17. PubMed PMID: 9389549.

[3] Luo S, Martel C, Sourla A, Gauthier S, Mérand Y, Belanger A, Labrie C, Labrie F. Comparative effects of 28-day treatment with the new anti-estrogen EM-800 and tamoxifen on estrogen-sensitive parameters in intact mice. Int J Cancer. 1997 Nov 4;73(3):381-91. PubMed PMID: 9359486.

[4] Labrie F, Champagne P, Labrie C, Roy J, Laverdière J, Provencher L, Potvin M, Drolet Y, Pollak M, Panasci L, L'Espérance B, Dufresne J, Latreille J, Robert J, Samson B, Jolivet J, Yelle L, Cusan L, Diamond P, Candas B. Activity and safety of the antiestrogen EM-800, the orally active precursor of acolbifene, in tamoxifen-resistant breast cancer. J Clin Oncol. 2004 Mar 1;22(5):864-71. PubMed PMID: 14990642.

[5] Luo S, Sourla A, Labrie C, Gauthier S, Merand Y, Belanger A, Labrie F. Effect of twenty-four-week treatment with the antiestrogen EM-800 on estrogen-sensitive parameters in intact and ovariectomized mice. Endocrinology. 1998 May;139(5):2645-56. PubMed PMID: 9564882.

6: Luo S, Sourla A, Labrie C, Bélanger A, Labrie F. Combined effects of dehydroepiandrosterone and EM-800 on bone mass, serum lipids, and the development of dimethylbenz(A)anthracene-induced mammary carcinoma in the rat. Endocrinology. 1997 Oct;138(10):4435-44. PubMed PMID: 9322961.7: Luo S, Stojanovic M, Labrie C, Labrie F. Inhibitory effect of the novel anti-estrogen EM-800 and medroxyprogesterone acetate on estrone-stimulated growth of dimethylbenz[a]anthracene-induced mammary carcinoma in rats. Int J Cancer. 1997 Nov 14;73(4):580-6. PubMed PMID: 9389575.8: Couillard S, Gutman M, Labrie F, Candas B, Labrie C. Effect of combined treatment with the pure antiestrogen EM-800 and radiotherapy on the growth of human ZR-75-1 breast cancer xenografts in nude mice. Cancer Res. 1999 Oct 1;59(19):4857-63. PubMed PMID: 10519396.9: Gutman M, Couillard S, Labrie F, Candas B, Labrie C. Effect of treatment sequence with radiotherapy and the antiestrogen EM 800 on the growth of ZR 75 1 human mammary carcinoma in nude mice. Int J Cancer. 2003 Jan 10;103(2):268-76. PubMed PMID: 12455043.10: Couillard S, Gutman M, Labrie C, Bélanger A, Candas B, Labrie F. Comparison of the effects of the antiestrogens EM-800 and tamoxifen on the growth of human breast ZR-75-1 cancer xenografts in nude mice. Cancer Res. 1998 Jan 1;58(1):60-4. PubMed PMID: 9426058.1

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