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DN 1417

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names：
(2S)-1-((5-oxotetrahydrofuran-2-carbonyl)-L-histidyl)pyrrolidine-2-carboxamide 2-hydroxypropane-1,2,3-tricarboxylate
CAS號：
77026-81-4
MDL Number：
MF(分子式)： C22H29N5O12 MW(分子量)： 555.49
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文別名	DN 1417
英文別名	DN 1417; DN-1417; DN1417;
CAS號	77026-81-4
Inchi	InChI=1S/C16H21N5O5.C6H8O7/c17-14(23)11-2-1-5-21(11)16(25)10(6-9-7-18-8-19-9)20-15(24)12-3-4-13(22)26-12;7-3(8)1-6(13,5(11)12)2-4(9)10/h7-8,10-12H,1-6H2,(H2,17,23)(H,18,19)(H,20,24);13H,1-2H2,(H,7,8)(H,9,10)(H,11,12)/t10-,11-,12?;/m0./s1
InchiKey	YYPBZNVNEDBLON-MEMPEZCVSA-N
分子式 Formula	C22H29N5O12
分子量 Molecular Weight	555.49
溶解度Solubility
性狀	Solid powder
儲藏條件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

產(chǎn)品說明	DN 1417(CAS:77026-81-4):僅限應(yīng)用于工業(yè)或者科學(xué)研究過程中非醫(yī)療目的，不應(yīng)用于人類或動物的臨床診斷以及治過程療，該產(chǎn)品非藥用，非食用。
Introduction	DN 1417 is a thyrotropin releasing hormone analog.
Application1
Application2
Application3

警示圖
危險性	Warning
危險性警示
安全聲明
安全防護
備注

[1]Nakahara T, Matsumoto T, Hirano M, Uchimura H, Yokoo H, Nakamura K, Ishibashi K, Hirano H. Effect of DN-1417, a thyrotropin releasing hormone analog, on dopaminergic neurons in rat brain. Peptides. 1985 Nov-Dec;6(6):1093-9. PubMed PMID: 3938840.

[2]Oshima I, Saito S, Shiota K, Miyake A, Oka Y, Nakayama R. Kinetic study on disappearance of gamma-butyrolactone-gamma-carbonyl-L-histidyl-L-prolinamide (DN-1417) from plasma using a radioimmunoassay for DN-1417 isobutylamide. J Pharmacobiodyn. 1983 Mar;6(3):202-8. PubMed PMID: 6410041.

[3] Mori N, Fukatsu T. Anticonvulsant effect of DN-1417, a derivative of thyrotropin-releasing hormone, and liposome-entrapped DN-1417, on amygdaloid-kindled rats. Epilepsia. 1992 Nov-Dec;33(6):994-1000. PubMed PMID: 1464282.

[4] Sakai S, Baba H, Sato M, Wada JA. Effect of DN-1417 on photosensitivity and cortically kindled seizure in Senegalese baboons, Papio papio. Epilepsia. 1991 Jan-Feb;32(1):16-21. PubMed PMID: 1898719.

[5] Hawley RJ, Kratz R, Goodman RR, McCutchen CB, Sirdofsky M, Hanson PA. Treatment of amyotrophic lateral sclerosis with the TRH analog DN-1417. Neurology. 1987 Apr;37(4):715-7. PubMed PMID: 3104820.

6: Mizuki Y, Ushijima I, Yamada M, Tanaka M, Inanaga K. A treatment trial with an analog of thyrotropin-releasing hormone (DN-1417) and des-tyrosine-gamma-endorphin in schizophrenia. Int Clin Psychopharmacol. 1986 Oct;1(4):303-13. PubMed PMID: 2881964.7: Nagai Y, Narumi S, Saji Y, Nagawa Y. [A TRH analog (DN-1417). Antagonistic effects on reserpine-induced decreases in local cerebral glucose utilization and cerebral monoamine levels]. Nihon Yakurigaku Zasshi. 1985 May;85(5):315-26. Japanese. PubMed PMID: 3928465.8: Nagai Y, Narumi S, Miyamoto M, Shima T, Saji Y, Nagawa Y. [A TRH analog (DN-1417). Effects on the levels of monoamines and the metabolites in the various brain regions in rats]. Nihon Yakurigaku Zasshi. 1985 Apr;85(4):209-20. Japanese. PubMed PMID: 3924795.9: Ogawa T, Moriwake T, Morimoto K, Sato M, Otsuki S. [The effect of a novel TRH analog (DN-1417) on postictal seizure inhibition in amygdaloid kindled cats]. No To Shinkei. 1984 Oct;36(10):951-5. Japanese. PubMed PMID: 6440585.10: Yokoo H, Nakahara T, Matsumoto T, Inanaga K, Uchimura H. Effect of TRH analog (DN-1417) on tyrosine hydroxylase activity in mesocortical, mesolimbic and nigrostriatal dopaminergic neurons of rat brain. Peptides. 1987 Jan-Feb;8(1):49-53. PubMed PMID: 2883633.1

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