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Dicentrine, (-)-

NMR下載 COA and HPLC MSDS下載
names：
(R)-10,11-dimethoxy-7-methyl-6,7,7a,8-tetrahydro-5H-[1,3]dioxolo[4',5'4,5]benzo[1,2,3-de]benzo[g]quinoline
CAS號(hào)：
28832-07-7
MDL Number：
MF(分子式)： C20H21NO4 MW(分子量)： 339.39
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文別名	Dicentrine, (-)-
英文別名	Dicentrine, (-)-; L-Dicentrine; NSC-251699; NSC 251699; NSC251699;
CAS號(hào)	28832-07-7
Inchi	InChI=1S/C20H21NO4/c1-21-5-4-11-7-17-20(25-10-24-17)19-13-9-16(23-3)15(22-2)8-12(13)6-14(21)18(11)19/h7-9,14H,4-6,10H2,1-3H3/t14-/m1/s1
InchiKey	YJWBWQWUHVXPNC-CQSZACIVSA-N
分子式 Formula	C20H21NO4
分子量 Molecular Weight	339.39
溶解度Solubility
性狀	Solid powder
儲(chǔ)藏條件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

產(chǎn)品說明	Dicentrine, (-)-(CAS:28832-07-7):僅限應(yīng)用于工業(yè)或者科學(xué)研究過程中非醫(yī)療目的，不應(yīng)用于人類或動(dòng)物的臨床診斷以及治過程療，該產(chǎn)品非藥用，非食用。
Introduction	Dicentrine, (-)- is an aporphinic alkaloid found in several plant species, mainly from Lauraceae family, which showed significant antinociceptive activity in an acute model of visceral pain in mice. It has also been shown to reduce spontaneous nociception and attenuating mechanical and cold hypersensitivity, probably via a TRPA1-dependent mechanism.
Application1
Application2
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警示圖
危險(xiǎn)性	Warning
危險(xiǎn)性警示
安全聲明
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[1]Tiwari S, Awasthi M, Singh S, Pandey VP, Dwivedi UN. Modulation of interaction of mutant TP53 and wild type BRCA1 by alkaloids: a computational approach towards targeting protein-protein interaction as a futuristic therapeutic intervention strategy for breast cancer impediment. J Biomol Struct Dyn. 2017 Oct 2

3:1-12. doi: 10.1080/07391102.2017.1388286. [Epub ahead of print] PubMed PMID: 28978265.

[3]Ma P, Li T, Ji F, Wang H, Pang J. Effect of GABA on blood pressure and blood dynamics of anesthetic rats. Int J Clin Exp Med. 2015 Aug 15;8(8):14296-302. eCollection 2015. PubMed PMID: 26550413; PubMed Central PMCID: PMC4613098.

[4]Lin HF, Huang HL, Liao JF, Shen CC, Huang RL. Dicentrine Analogue-Induced G2/M Arrest and Apoptosis through Inhibition of Topoisomerase II Activity in Human Cancer Cells. Planta Med. 2015 Jul;81(10):830-7. doi: 10.1055/s-0035-1546128. Epub 2015 Jul 9. PubMed PMID: 26158522.

[5] Dong JW, Cai L, Fang YS, Xiao H, Li ZJ, Ding ZT. Proaporphine and aporphine alkaloids with acetylcholinesterase inhibitory activity from Stephania epigaea. Fitoterapia. 2015 Jul;10

4:102-7. doi: 10.1016/j.fitote.2015.05.019. Epub 2015 May 29. PubMed PMID: 26028544.

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