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Desferrithiocin

NMR下載 COA and HPLC MSDS下載
names：
(S)-4,5-Dihydro-2-(3-hydroxy-2-pyridinyl)-4-methyl-4-thiazolecarboxylic acid monosodium salt
CAS號(hào)：
105635-60-6
MDL Number：
MF(分子式)： C10H9N2NaO3S MW(分子量)： 260.24
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文別名	Desferrithiocin
英文別名	Desferrithiocin; DFT;
CAS號(hào)	105635-60-6
Inchi	InChI=1S/C10H10N2O3S.Na/c1-10(9(14)15)5-16-8(12-10)7-6(13)3-2-4-11-7;/h2-4,13H,5H2,1H3,(H,14,15);/q;+1/p-1/t10-;/m1./s1
InchiKey	UGJSEILLHZKUBG-HNCPQSOCSA-M
分子式 Formula	C10H9N2NaO3S
分子量 Molecular Weight	260.24
溶解度Solubility
性狀	Solid powder
儲(chǔ)藏條件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

產(chǎn)品說明	Desferrithiocin(CAS:105635-60-6):僅限應(yīng)用于工業(yè)或者科學(xué)研究過程中非醫(yī)療目的，不應(yīng)用于人類或動(dòng)物的臨床診斷以及治過程療，該產(chǎn)品非藥用，非食用。
Introduction	Desferrithiocin is an orally effective Fe chelator that is more active than desferrioxamine.
Application1
Application2
Application3

警示圖
危險(xiǎn)性	Warning
危險(xiǎn)性警示
安全聲明
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[1]Taher AT, Saliba AN, Kuo KH, Giardina PJ, Cohen AR, Neufeld EJ, Aydinok Y, Kwiatkowski JL, Jeglinski BI, Pietropaolo K, Berk G, Viprakasit V. Safety and pharmacokinetics of the oral iron chelator SP-420 in β-thalassemia. Am J Hematol. 2017 Dec;92(12):1356-136[1]doi: 10.1002/ajh.24914. Epub 2017 Oct 3[1]PubMed PMID: 28940308.

[2]Kaviani S, Izadyar M, Housaindokht MR. A DFT study on the complex formation between desferrithiocin and metal ions (Mg(2+), Al(3+), Ca(2+), Mn(2+), Fe(3+), Co(2+), Ni(2+), Cu(2+), Zn(2+)). Comput Biol Chem. 2017 Apr;67:114-121. doi: 10.1016/j.compbiolchem.2016.12.012. Epub 2017 Jan 3. PubMed PMID: 28068516.

[3] Bergeron RJ, Bharti N, McManis JS, Wiegand J. Metabolically programmed iron chelators. Bioorg Med Chem. 2015 Sep 1;23(17):5954-71. doi: 10.1016/j.bmc.2015.06.059. Epub 2015 Jun 29. PubMed PMID: 26231739; PubMed Central PMCID: PMC4608554.

[4] Hider RC, Kong X, Abbate V, Harland R, Conlon K, Luker T. Deferitazole, a new orally active iron chelator. Dalton Trans. 2015 Mar 21;44(11):5197-204. doi: 10.1039/c5dt00063g. PubMed PMID: 25687725.

[5] Bergeron RJ, Wiegand J, McManis JS, Bharti N. Desferrithiocin: a search for clinically effective iron chelators. J Med Chem. 2014 Nov 26;57(22):9259-91. doi: 10.1021/jm500828f. Epub 2014 Sep 10. Review. PubMed PMID: 25207964; PubMed Central PMCID: PMC4255733.

6: Bergeron RJ, Wiegand J, Bharti N, McManis JS. Substituent effects on desferrithiocin and desferrithiocin analogue iron-clearing and toxicity profiles. J Med Chem. 2012 Aug 23;55(16):7090-103. doi: 10.1021/jm300509y. Epub 2012 Aug 13. PubMed PMID: 22889170; PubMed Central PMCID: PMC3583384.7: Bergeron RJ, Wiegand J, Bharti N, McManis JS, Singh S. Desferrithiocin analogue iron chelators: iron clearing efficiency, tissue distribution, and renal toxicity. Biometals. 2011 Apr;24(2):239-58. doi: 10.1007/s10534-010-9389-y. Epub 2010 Nov 20. PubMed PMID: 21103911; PubMed Central PMCID: PMC3329216.8: Bergeron RJ, Bharti N, Wiegand J, McManis JS, Singh S, Abboud KA. The impact of polyether chain length on the iron clearing efficiency and physiochemical properties of desferrithiocin analogues. J Med Chem. 2010 Apr 8;53(7):2843-53. doi: 10.1021/jm9018146. PubMed PMID: 20232803; PubMed Central PMCID: PMC2951135.9: Bergeron RJ, Wiegand J, Singh S. Desferrithiocin analogue uranium decorporation agents. Int J Radiat Biol. 2009 Apr;85(4):348-61. doi: 10.1080/09553000902781089. PubMed PMID: 19399680; PubMed Central PMCID: PMC2861555.10: Bergeron RJ, Wiegand J, McManis JS, Bharti N, Singh S. Desferrithiocin analogues and nephrotoxicity. J Med Chem. 2008 Oct 9;51(19):5993-6004. doi: 10.1021/jm8003398. Epub 2008 Sep 13. PubMed PMID: 18788724; PubMed Central PMCID: PMC2778308.1

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