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Demethoxyviridin

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names：
(1R,11bR)-1-Hydroxy-11b-methyl-1,7,8,11b-tetrahydrocyclopenta[7,8]phenanthro[10,1-bc]furan-3,6,9(2H)-trione
CAS號(hào)：
56660-21-0
MDL Number：
MF(分子式)： C19H14O5 MW(分子量)： 322.32
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文別名	Demethoxyviridin
英文別名	Demethoxyviridin; DMV
CAS號(hào)	56660-21-0
Inchi	InChI=1S/C19H14O5/c1-19-11-4-2-8-9(3-5-12(8)20)15(11)17(23)18-16(19)10(7-24-18)13(21)6-14(19)22/h2,4,7,14,22H,3,5-6H2,1H3/t14-,19+/m1/s1
InchiKey	SWJBYJJNDIXFSA-KUHUBIRLSA-N
分子式 Formula	C19H14O5
分子量 Molecular Weight	322.32
溶解度Solubility
性狀	Solid powder
儲(chǔ)藏條件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

產(chǎn)品說(shuō)明	Demethoxyviridin(CAS:56660-21-0):僅限應(yīng)用于工業(yè)或者科學(xué)研究過(guò)程中非醫(yī)療目的，不應(yīng)用于人類(lèi)或動(dòng)物的臨床診斷以及治過(guò)程療，該產(chǎn)品非藥用，非食用。
Introduction	Demethoxyviridin, or DMV, is a low-nanomolar inhibitor of mammalian Ptdlns 3-kinase that binds to the catalytic subunit (p110) of the enzyme. Demethoxyviridin is also an antifungal agent structurally related to wortmannin.
Application1
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Application3

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[1]Kiran I, Ilhan S, Akar T, Tur L, Erol E. Synthesis and evaluation of demethoxyviridin derivatives as potential antimicrobials. Z Naturforsch C. 2005 Sep-Oct;60(9-10):686-92. PubMed PMID: 16320609.

[2]Yuan H, Pupo MT, Blois J, Smith A, Weissleder R, Clardy J, Josephson L. A stabilized demethoxyviridin derivative inhibits PI3 kinase. Bioorg Med Chem Lett. 2009 Aug 1;19(15):4223-7. doi: 10.1016/j.bmcl.2009.05.105. Epub 2009 May 30. PubMed PMID: 19523825; PubMed Central PMCID: PMC2877487.

[3] Giner JL, Kehbein KA, Cook JA, Smith MC, Vlahos CJ, Badwey JA. Synthesis of fluorescent derivatives of wortmannin and demethoxyviridin as probes for phosphatidylinositol 3-kinase. Bioorg Med Chem Lett. 2006 May 1;16(9):2518-21. Epub 2006 Feb 7. PubMed PMID: 16464575.

[4] Zheng QC, Chen GD, Kong MZ, Li GQ, Cui JY, Li XX, Wu ZY, Guo LD, Cen YZ, Zheng YZ, Gao H. Nodulisporisteriods A and B, the first 3,4-seco-4-methyl-progesteroids from Nodulisporium sp. Steroids. 2013 Sep;78(9):896-901. doi: 10.1016/j.steroids.2013.05.007. Epub 2013 May 17. PubMed PMID: 23685090.

[5] Bonser RW, Thompson NT, Randall RW, Tateson JE, Spacey GD, Hodson HF, Garland LG. Demethoxyviridin and wortmannin block phospholipase C and D activation in the human neutrophil. Br J Pharmacol. 1991 May;103(1):1237-41. PubMed PMID: 1908735; PubMed Central PMCID: PMC1908105.

6: Petritsch C, Woscholski R, Edelmann HM, Parker PJ, Ballou LM. Selective inhibition of p70 S6 kinase activation by phosphatidylinositol 3-kinase inhibitors. Eur J Biochem. 1995 Jun 1;230(2):431-8. PubMed PMID: 7607212.7: Woscholski R, Kodaki T, McKinnon M, Waterfield MD, Parker PJ. A comparison of demethoxyviridin and wortmannin as inhibitors of phosphatidylinositol 3-kinase. FEBS Lett. 1994 Apr 4;342(2):109-14. PubMed PMID: 8143860.8: Baumruker T, Pendl GG, Prieschl EE. Gene regulation after Fc epsilon RI stimulation in the murine mast cell line CPII. Int Arch Allergy Immunol. 1997 May-Jul;113(1-3):39-41. PubMed PMID: 9130478.9: Pendl GG, Prieschl EE, Thumb W, Harrer NE, Auer M, Baumruker T. Effects of phosphatidylinositol-3-kinase inhibitors on degranulation and gene induction in allergically triggered mouse mast cells. Int Arch Allergy Immunol. 1997 Apr;112(4):392-9. PubMed PMID: 9104796.10: Cross MJ, Hodgkin MN, Plumb JA, Brunton VG, Stewart A, MacAully G, Hill R, Kerr DJ, Workman P, Wakelam MJ. Inhibition of phospholipid signalling and proliferation of Swiss 3T3 cells by the wortmannin analogue demethoxyviridin. Biochim Biophys Acta. 1997 Nov 28;1362(1):29-38. PubMed PMID: 9434097.1

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