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Debutyldronedarone

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names：
Methanesulfonamide, N-(2-butyl-3-(4-(3-(butylamino)propoxy)benzoyl)-5-benzofuranyl)-
CAS號：
141626-35-9
MDL Number：
MF(分子式)： C27H36N2O5S MW(分子量)： 500.65
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文別名	Debutyldronedarone
英文別名	Debutyldronedarone; SR 35021; UNII-C3801M93QC.
CAS號	141626-35-9
Inchi	InChI=1S/C27H36N2O5S/c1-4-6-9-25-26(23-19-21(29-35(3,31)32)12-15-24(23)34-25)27(30)20-10-13-22(14-11-20)33-18-8-17-28-16-7-5-2/h10-15,19,28-29H,4-9,16-18H2,1-3H3
InchiKey	IJVZZGIAELTWBB-UHFFFAOYSA-N
分子式 Formula	C27H36N2O5S
分子量 Molecular Weight	500.65
溶解度Solubility
性狀	Solid powder
儲藏條件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

產品說明	Debutyldronedarone(CAS:141626-35-9):僅限應用于工業(yè)或者科學研究過程中非醫(yī)療目的，不應用于人類或動物的臨床診斷以及治過程療，該產品非藥用，非食用。
Introduction	Debutyldronedarone is a major circulating active metabolite of dronedarone in humans. Dronedarone is a derivative of amiodarone--a popular antiarrhythmic drug. It was developed to overcome the limiting iodine-associated toxicities of amiodarone.
Application1
Application2
Application3

警示圖
危險性	Warning
危險性警示
安全聲明
安全防護
備注

[1]Santos M, García LC, Checura C, Donadío LG, Fernandez C, Orgueira H, Comin MJ. Synthesis and characterization of new related substances of the antiarrhythmic drug dronedarone hydrochloride. J Pharm Biomed Anal. 2015 Oct 10;11

4:441-6. doi: 10.1016/j.jpba.2015.06.026. Epub 2015 Jun 22. PubMed PMID: 26133102.

[3]van Beeren HC, Kwakkel J, Ackermans MT, Wiersinga WM, Fliers E, Boelen A. Action of specific thyroid hormone receptor α(1) and β(1) antagonists in the central and peripheral regulation of thyroid hormone metabolism in the rat. Thyroid. 2012 Dec;22(12):1275-82. doi: 10.1089/thy.2012.0135. PubMed PMID: 22985455.

[4]Xie C, Yang S, Zhong D, Dai X, Chen X. Simultaneous determination of dronedarone and its active metabolite debutyldronedarone in human plasma by liquid chromatography-tandem mass spectrometry: application to a pharmacokinetic study. J Chromatogr B Analyt Technol Biomed Life Sci. 2011 Oct 15;879(28):3071-5. doi: 10.1016/j.jchromb.2011.09.004. Epub 2011 Sep 9. PubMed PMID: 21937291.

[5] Bolderman RW, Hermans JJ, Maessen JG. Determination of the class III antiarrhythmic drugs dronedarone and amiodarone, and their principal metabolites in plasma and myocardium by high-performance liquid chromatography and UV-detection. J Chromatogr B Analyt Technol Biomed Life Sci. 2009 Jun 15;877(18-19):1727-31. doi: 10.1016/j.jchromb.2009.04.029. Epub 2009 Apr 24. PubMed PMID: 19427276.

5: Van Beeren HC, Jong WM, Kaptein E, Visser TJ, Bakker O, Wiersinga WM. Dronerarone acts as a selective inhibitor of 3,5,3'-triiodothyronine binding to thyroid hormone receptor-alpha

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