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Darotropium bromide

NMR下載 COA and HPLC MSDS下載
names：
(1R,5R)-3-(2-cyano-2,2-diphenylethyl)-8,8-dimethyl-8-azabicyclo[3.2.1]octan-8-ium bromide
CAS號(hào)：
850607-58-8
MDL Number：
MF(分子式)： C24H29BrN2 MW(分子量)： 425.414
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文別名	Darotropium bromide
英文別名	GSK233705B; GSK 233705B; GSK-233705B; GSK233705; GSK 233705; GSK-233705; Darotropium bromide
CAS號(hào)	850607-58-8
Inchi	InChI=1S/C24H29N2.BrH/c1-26(2)22-13-14-23(26)16-19(15-22)17-24(18-25,20-9-5-3-6-10-20)21-11-7-4-8-12-21;/h3-12,19,22-23H,13-17H2,1-2H3;1H/q+1;/p-1/t22-,23-;/m1./s1
InchiKey	CWRNUVNMUYSOFQ-OHIDFYLOSA-M
分子式 Formula	C24H29BrN2
分子量 Molecular Weight	425.414
溶解度Solubility
性狀	Solid powder
儲(chǔ)藏條件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

產(chǎn)品說明	Darotropium bromide(CAS:850607-58-8):僅限應(yīng)用于工業(yè)或者科學(xué)研究過程中非醫(yī)療目的，不應(yīng)用于人類或動(dòng)物的臨床診斷以及治過程療，該產(chǎn)品非藥用，非食用。
Introduction	Darotropium bromide is discontinued (DEA controlled substance). Darotropium bromide, also known as GSK233705 or GSK233705B, is an inhaled, long-acting muscarinic antagonist in development for the treatment of chronic obstructive pulmonary disease (COPD). GSK233705 demonstrated bronchodilatory activity and were well tolerated. Although the onset of bronchodilation was rapid, it was not sustained over 24 h making it unsuitable for once-daily dosing.
Application1
Application2
Application3

警示圖
危險(xiǎn)性	Warning
危險(xiǎn)性警示
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[1]Beier J, van Noord J, Deans A, Brooks J, Maden C, Baggen S, Mehta R, Cahn A.Safety and efficacy of dual therapy with GSK233705 and salmeterol versusmonotherapy with salmeterol, tiotropium, or placebo in a crossover pilot study inpartially reversible COPD patients. Int J Chron Obstruct Pulmon Dis.2012;7:153-64. doi: 10.2147/COPD.S26100. Epub 2012 Mar 5. PubMed PMID: 22419863;PubMed Central PMCID: PMC3299545.

[2]Bateman E, Feldman G, Kilbride S, Brooks J, Mehta R, Harris S, Maden C, CraterG. Efficacy and safety of the long-acting muscarinic antagonist GSK233705delivered once daily in patients with COPD. Clin Respir J. 2012 Oct;6(4):248-57.doi: 10.1111/j.1752-699X.2011.00278.x. Epub 2012 Feb 13. PubMed PMID: 22329914.

[3] Cazzola M, Matera MG. Novel long-acting bronchodilators for COPD and asthma.Br J Pharmacol. 2008 Oct;155(3):291-9. doi: 10.1038/bjp.2008.284. Epub 2008 Jul7. Review. PubMed PMID: 18604231; PubMed Central PMCID: PMC2567883.

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