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CM-10-18

NMR下載 COA and HPLC MSDS下載
names：
(2R,3R,4R,5S)-1-(7-ethyl-7-hydroxynonyl)-2-(hydroxymethyl)-3,4,5-piperidinetriol
CAS號(hào)：
1159614-57-9
MDL Number：
MF(分子式)： C17H35NO5 MW(分子量)： 333.469
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文別名	CM-10-18
英文別名	CM-10-18; CM-10-18; CM-10-18; CM-1018; CM-1018; CM-1018.
CAS號(hào)	1159614-57-9
Inchi	InChI=1S/C17H35NO5/c1-3-17(23,4-2)9-7-5-6-8-10-18-11-14(20)16(22)15(21)13(18)12-19/h13-16,19-23H,3-12H2,1-2H3/t13-,14+,15-,16-/m1/s1
InchiKey	VLVMPUBHMJVGPH-QKPAOTATSA-N
分子式 Formula	C17H35NO5
分子量 Molecular Weight	333.469
溶解度Solubility
性狀	Solid powder
儲(chǔ)藏條件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

產(chǎn)品說明	CM-10-18(CAS:1159614-57-9):僅限應(yīng)用于工業(yè)或者科學(xué)研究過程中非醫(yī)療目的，不應(yīng)用于人類或動(dòng)物的臨床診斷以及治過程療，該產(chǎn)品非藥用，非食用。
Introduction	CM-10-18 is a potent ER α-glucosidase inhibitor. CM-10-18 efficiently protected the lethality of dengue virus infection of mice. CM-10-18 demonstrated superior in vitro antiviral activity against representative viruses from four viral families causing hemorrhagic fever.
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[1]Chang J, Warren TK, Zhao X, Gill T, Guo F, Wang L, Comunale MA, Du Y, Alonzi DS, Yu W, Ye H, Liu F, Guo JT, Mehta A, Cuconati A, Butters TD, Bavari S, Xu X, Block TM. Small molecule inhibitors of ER α-glucosidases are active against multiple hemorrhagic fever viruses. Antiviral Res. 2013 Jun;98(3):432-40. doi: 10.1016/j.antiviral.2013.03.023. PubMed PMID: 23578725; PubMed Central PMCID: PMC3663898.

[2]Chang J, Schul W, Yip A, Xu X, Guo JT, Block TM. Competitive inhibitor of cellular α-glucosidases protects mice from lethal dengue virus infection. Antiviral Res. 2011 Nov;92(2):369-71. doi: 10.1016/j.antiviral.2011.08.003. PubMed PMID: 21854808; PubMed Central PMCID: PMC3209657.

[3] Chang J, Schul W, Butters TD, Yip A, Liu B, Goh A, Lakshminarayana SB, Alonzi D, Reinkensmeier G, Pan X, Qu X, Weidner JM, Wang L, Yu W, Borune N, Kinch MA, Rayahin JE, Moriarty R, Xu X, Shi PY, Guo JT, Block TM. Combination of α-glucosidase inhibitor and ribavirin for the treatment of dengue virus infection in vitro and in vivo. Antiviral Res. 2011 Jan;89(1):26-34. doi: 10.1016/j.antiviral.2010.11.002. PubMed PMID: 21073903; PubMed Central PMCID: PMC3018560.

[4] Yu W, Gill T, Wang L, Du Y, Ye H, Qu X, Guo JT, Cuconati A, Zhao K, Block TM, Xu X, Chang J. Design, synthesis, and biological evaluation of N-alkylated deoxynojirimycin (DNJ) derivatives for the treatment of dengue virus infection. J Med Chem. 2012 Jul 12;55(13):6061-75. doi: 10.1021/jm300171v. PubMed PMID: 22712544; PubMed Central PMCID: PMC3395807.

[5] Zhao X, Guo F, Comunale MA, Mehta A, Sehgal M, Jain P, Cuconati A, Lin H, Block TM, Chang J, Guo JT. Inhibition of endoplasmic reticulum-resident glucosidases impairs severe acute respiratory syndrome coronavirus and human coronavirus NL63 spike protein-mediated entry by altering the glycan processing of angiotensin I-converting enzyme 2. Antimicrob Agents Chemother. 2015 Jan;59(1):206-16. doi: 10.1128/AAC.03999-14. PubMed PMID: 25348530; PubMed Central PMCID: PMC4291352.

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