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CL-184005

NMR下載 COA and HPLC MSDS下載
names：
2-(methoxycarbonyl)-3-(tetradecyloxy)phenyl (3-((5-methylthiazol-3-ium-3-yl)methyl)phenyl) phosphate
CAS號：
140466-18-8
MDL Number：
MF(分子式)： C33H46NO7PS MW(分子量)： 631.7648
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文別名	CL-184005
英文別名	CL-184005; CL 184005; CL184005
CAS號	140466-18-8
Inchi	InChI=1S/C33H46NO7PS/c1-4-5-6-7-8-9-10-11-12-13-14-15-22-39-30-20-17-21-31(32(30)33(35)38-3)41-42(36,37)40-29-19-16-18-28(23-29)25-34-24-27(2)43-26-34/h16-21,23-24,26H,4-15,22,25H2,1-3H3
InchiKey	VGVUQNMRGKNUJA-UHFFFAOYSA-N
分子式 Formula	C33H46NO7PS
分子量 Molecular Weight	631.7648
溶解度Solubility
性狀	Solid powder
儲藏條件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

產(chǎn)品說明	CL-184005(CAS:140466-18-8):僅限應(yīng)用于工業(yè)或者科學(xué)研究過程中非醫(yī)療目的，不應(yīng)用于人類或動(dòng)物的臨床診斷以及治過程療，該產(chǎn)品非藥用，非食用。
Introduction	CL-184005 is a platelet activating factor (PAF) inhibitor potentially for the treatment of gram-negative bacterial infection and septic shock. CL-184005 interferes with tumor necrosis factor synthesis induced by S. aureus. Spleen-associated tumor necrosis factor protein was also decreased by pretreatment with CL-184005.
Application1
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Application3

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危險(xiǎn)性	Warning
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[1]Negro Alvarez JM, Miralles López JC, Ortiz Martínez JL, Abellán Alemán A, Rubio del Barrio R. Platelet-activating factor antagonists. Allergol Immunopathol (Madr). 1997 Sep-Oct;25(5):249-58. Review. PubMed PMID: 9395010.

[2]Chen J, Giris N. Species differences in PAF receptor binding in the lungs between hamster and guinea pig. J Lipid Mediat Cell Signal. 1997 Jun;16(2):63-74. PubMed PMID: 9172049.

[3] Dirkes K, Harris BH, Connolly RJ, Schwaitzberg SD, Dinarello CA, Gelfand JA. Platelet activating factor-antagonist improves survival in experimental staphylococcal septicemia. J Pediatr Surg. 1994 Aug;29(8):1055-7; discussion 1057-8. PubMed PMID: 7965505.

[4] DeJoy SQ, Jeyaseelan R Sr, Torley LW, Pickett WC, Wissner A, Wick MM, Oronsky AL, Kerwar SS. Effect of CL 184,005, a platelet-activating factor antagonist in a murine model of Staphylococcus aureus-induced gram-positive sepsis. J Infect Dis. 1994 Jan;169(1):150-6. PubMed PMID: 8277176.

[5] Tao W, Dougherty R, Johnston P, Pickett W. Recombinant bovine GM-CSF primes superoxide production but not degranulation induced by recombinant bovine interleukin-1 beta in bovine neutrophils. J Leukoc Biol. 1993 Jun;53(6):679-84. PubMed PMID: 8391055.

6: Torley LW, Pickett WC, Carroll ML, Kohler CA, Schaub RE, Wissner A, DeJoy SQ, Oronsky AL, Kerwar SS. Studies of the effect of a platelet-activating factor antagonist, CL 184,005, in animal models of gram-negative bacterial sepsis. Antimicrob Agents Chemother. 1992 Sep;36(9):1971-7. PubMed PMID: 1416889; PubMed Central PMCID: PMC192217.7: Wissner A, Carroll ML, Green KE, Kerwar SS, Pickett WC, Schaub RE, Torley LW, Wrenn S, Kohler CA. Analogues of platelet activating factor. 6. Mono- and bis-aryl phosphate antagonists of platelet activating factor. J Med Chem. 1992 May 1;35(9):1650-62. PubMed PMID: 1578493.

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