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Chetomin

NMR下載 COA and HPLC MSDS下載
names：
Chetomin, HIF signaling inhibitor
CAS號：
1403-36-7
MDL Number：
MF(分子式)： C31H30N6O6S4 MW(分子量)： 710.857
EINECS: Reaxys Number:
Pubchem ID:10417379 Brand:BIOFOUNT

Chetomin(1403-36-7)是一種從毛殼菌屬中分離的天然產(chǎn)物，具有抗菌和抗真菌特性。它是一種低氧誘導(dǎo)因子 (HIF) 信號傳導(dǎo)的小分子抑制劑，在低納摩爾濃度下破壞 HIF-1α 和 HIF-2α 與 p300 的結(jié)合，Chetomin 可有效減弱細(xì)胞和小鼠體內(nèi)的 HIF 通路。它抑制癌細(xì)胞和異種移植物中的 HIF 依賴性信號傳導(dǎo)、細(xì)胞生長和腫瘤生長。

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中文別名	Chetomin(1403-36-7);HIF信號抑制劑;HIF signaling inhibitor
英文別名	Chetomin, HIF signaling inhibitor(1403-36-7);CTM;NSC-289491;NSC 289491;NSC289491
CAS號	1403-36-7
Inchi	InChI=1S/C31H30N6O6S4/c1-33-25(42)30(15-38)34(2)23(40)28(33,44-46-30)12-17-13-36(21-11-7-4-8-18(17)21)27-14-29-24(41)35(3)31(16-39,47-45-29)26(43)37(29)22(27)32-20-10-6-5-9-19(20)27/h4-11,13,22,32,38-39H,12,14-16H2,1-3H3/t22-,27+,28+,29+,30+,31+/m1/s1
InchiKey	ZRZWBWPDBOVIGQ-YWZWRZHGSA-N
分子式 Formula	C31H30N6O6S4
分子量 Molecular Weight	710.857
溶解度Solubility
性狀	白色至淺黃色固體
儲藏條件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

產(chǎn)品說明	Chetomin(1403-36-7)是一種從毛殼菌屬中分離的天然產(chǎn)物，具有抗菌和抗真菌特性。它是一種低氧誘導(dǎo)因子 (HIF) 信號傳導(dǎo)的小分子抑制劑，在低納摩爾濃度下破壞 HIF-1α 和 HIF-2α 與 p300 的結(jié)合，Chetomin 可有效減弱細(xì)胞和小鼠體內(nèi)的 HIF 通路。
Introduction	Chetomin is a natural product isolated from Chaetomium species which has antibacterial and antifungal properties. Chetomin induces degradation of XIAP and enhances TRAIL sensitivity in urogenital cancer cells. Chetomin, targeting HIF-1α/p300 complex, exhibits antitumour activity in multiple myeloma.
Application1
Application2
Application3

警示圖
危險(xiǎn)性	Warning
危險(xiǎn)性警示	P264處理后徹底清洗+P280戴防護(hù)手套/穿防護(hù)服/戴防護(hù)眼罩/戴防護(hù)面具+P305如果進(jìn)入眼睛+P351用水小心沖洗幾分鐘+P338取出隱形眼鏡（如果有）并且易于操作,繼續(xù)沖洗+P337如果眼睛刺激持續(xù)+P313獲得醫(yī)療建議/護(hù)理
安全聲明	H315 H319 H335
安全防護(hù)	P264 P302+P352 P304+P340 P305+P351+P338 P332+P313 P337+P313
備注

[1]Wu Q, Li G, Deng S, Ouyang L, Li L, Liu L, Luo N, Song X, He G, Gong C, Wei Y. Enhanced antitumor activity and mechanism of biodegradable polymeric micelles-encapsulated chetomin in both transgenic zebrafish and mouse models. Nanoscale. 2014 Oct 21;6(20):11940-52. doi: 10.1039/c4nr02978j. Epub 2014 Sep [1] PubMed PMID: 25175172.

[2]Yano K, Horinaka M, Yoshida T, Yasuda T, Taniguchi H, Goda AE, Wakada M, Yoshikawa S, Nakamura T, Kawauchi A, Miki T, Sakai T. Chetomin induces degradation of XIAP and enhances TRAIL sensitivity in urogenital cancer cells. Int J Oncol. 2011 Feb;38(2):365-74. doi: 10.3892/ijo.2010.874. Epub 2010 Dec 15. PubMed PMID: 21165560.

[3] Welch TR, Williams RM. Studies on the Biosynthesis of Chetomin: Enantiospecific Synthesis of a Putative, Late-Stage Biosynthetic Intermediate. Tetrahedron. 2013 Jan 1;69(2):770-773. PubMed PMID: 24489414; PubMed Central PMCID: PMC3908826.

[4] Viziteu E, Grandmougin C, Goldschmidt H, Seckinger A, Hose D, Klein B, Moreaux J. Chetomin, targeting HIF-1α/p300 complex, exhibits antitumour activity in multiple myeloma. Br J Cancer. 2016 Mar 1;114(5):519-23. doi: 10.1038/bjc.2016.20. Epub 2016 Feb 11. PubMed PMID: 26867162; PubMed Central PMCID: PMC4782210.

[5] Staab A, Loeffler J, Said HM, Diehlmann D, Katzer A, Beyer M, Fleischer M, Schwab F, Baier K, Einsele H, Flentje M, Vordermark D. Effects of HIF-1 inhibition by chetomin on hypoxia-related transcription and radiosensitivity in HT 1080 human fibrosarcoma cells. BMC Cancer. 2007 Nov 13;7:213. PubMed PMID: 17999771; PubMed Central PMCID: PMC2200672.

6: Jin Z, Aixi Y, Baiwen Q, Zonghuan L, Xiang H. Inhibition of hypoxia-inducible factor-1 alpha radiosensitized MG-63 human osteosarcoma cells in vitro. Tumori. 2015 Sep-Oct;101(5):578-84. doi: 10.5301/tj.5000243. Epub 2015 Aug 4. PubMed PMID: 26350185.7: Kessler J, Hahnel A, Wichmann H, Rot S, Kappler M, Bache M, Vordermark D. HIF-1α inhibition by siRNA or chetomin in human malignant glioma cells: effects on hypoxic radioresistance and monitoring via CA9 expression. BMC Cancer. 2010 Nov 4;10:605. doi: 10.1186/1471-2407-10-605. PubMed PMID: 21050481; PubMed Central PMCID: PMC2992520.8: Jen WC, Jones GA. Effects of chetomin on growth and acidic fermentation products of rumen bacteria. Can J Microbiol. 1983 Oct;29(10):1399-404. PubMed PMID: 6686488.9: Hiraki M, Hwang SY, Cao S, Ramadhar TR, Byun S, Yoon KW, Lee JH, Chu K, Gurkar AU, Kolev V, Zhang J, Namba T, Murphy ME, Newman DJ, Mandinova A, Clardy J, Lee SW. Small-Molecule Reactivation of Mutant p53 to Wild-Type-like p53 through the p53-Hsp40 Regulatory Axis. Chem Biol. 2015 Sep 17;22(9):1206-16. doi: 10.1016/j.chembiol.2015.07.016. Epub 2015 Aug 27. PubMed PMID: 26320861; PubMed Central PMCID: PMC4670040.10: Reece KM, Richardson ED, Cook KM, Campbell TJ, Pisle ST, Holly AJ, Venzon DJ, Liewehr DJ, Chau CH, Price DK, Figg WD. Epidithiodiketopiperazines (ETPs) exhibit in vitro antiangiogenic and in vivo antitumor activity by disrupting the HIF-1α/p300 complex in a preclinical model of prostate cancer. Mol Cancer. 2014 Apr 28;1

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