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Bencycloquidium Bromide

NMR下載 COA and HPLC MSDS下載
names：
3-(2-cyclopentyl-2-hydroxy-2-phenylethoxy)-1-methylquinuclidin-1-ium bromide
CAS號(hào)：
860804-18-8
MDL Number：
MF(分子式)： C21H32BrNO2 MW(分子量)： 410.396
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文別名	Bencycloquidium Bromide
英文別名	Bencycloquidium Bromide; BCQB.
CAS號(hào)	860804-18-8
Inchi	InChI=1S/C21H32NO2.BrH/c1-22-13-11-17(12-14-22)20(15-22)24-16-21(23,19-9-5-6-10-19)18-7-3-2-4-8-18;/h2-4,7-8,17,19-20,23H,5-6,9-16H2,1H3;1H/q+1;/p-1
InchiKey	LMUJEWVKOCYOQL-UHFFFAOYSA-M
分子式 Formula	C21H32BrNO2
分子量 Molecular Weight	410.396
溶解度Solubility
性狀	Solid powder
儲(chǔ)藏條件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

產(chǎn)品說(shuō)明	Bencycloquidium Bromide(CAS:860804-18-8):僅限應(yīng)用于工業(yè)或者科學(xué)研究過(guò)程中非醫(yī)療目的，不應(yīng)用于人類或動(dòng)物的臨床診斷以及治過(guò)程療，該產(chǎn)品非藥用，非食用。
Introduction	Bencycloquidium Bromide, also known as BCQB, is a muscarinic M3 antagonist potentially for the treatment of allergic rhinitis and chronic obstructive. Bencycloquidium bromide inhibits nasal hypersecretion in a rat model of allergic rhinitis. BCQB showed high affinity toward the M(3) receptor in Chinese hamster ovary (CHO) cells (M(3) pKi=8.21, M(2) pKi=7.21, and M(1) pKi=7.86); pA(2)=8.85, 8.71 and 8.57 in methacholine-induced contraction of trachea, ileum and urinary bladder, 8.19 in methacholine-induced bradycardia of right atrium in vitro, respectively.
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危險(xiǎn)性	Warning
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[1]Zhang SJ, Jiang JX, Ren QQ, Xie QM, Xiong YK. Effects of the inhalation of the m3 receptor antagonist bencycloquidium bromide in a mouse cigarette smoke-induced airway inflammation model. Drug Dev Res. 2015 May;76(3):123-3[1]doi: 10.1002/ddr.21248. Epub 2015 May 1[1]PubMed PMID: 25958838.

[2]Long R, Zhou Y, Huang J, Peng L, Meng L, Zhu S, Li J. Bencycloquidium bromide inhibits nasal hypersecretion in a rat model of allergic rhinitis. Inflamm Res. 2015 Apr;64(3-4):213-23. doi: 10.1007/s00011-015-0800-6. Epub 2015 Feb 18. PubMed PMID: 25690567.

[3] Agbokponto JE, Luo Z, Liu R, Liu Z, Liang M, Ding L. Study of pharmacokinetic interaction of paroxetine and roxithromycin on bencycloquidium bromide in healthy subjects. Eur J Pharm Sci. 2015 Mar 10;69:37-43. doi: 10.1016/j.ejps.2014.12.019. Epub 2015 Jan 2. PubMed PMID: 25559065.

[4] Agbokponto JE, Zhang L, Hu L, Feng H, Ding L. In vitro metabolism of bencycloquidium bromide and its inhibitory effects on human P450 isoenzymes: implication of CYP2D6, CYP2C19 and CYP3A4/5. Eur J Drug Metab Pharmacokinet. 2016 Feb;41(1):69-77. doi: 10.1007/s13318-014-0237-2. Epub 2014 Nov 26. PubMed PMID: 25425116.

[5] Sun L, Ding L, Wang Y, Zhou W, Yan Z, Sun W, Zhang H, Ou N, Chen X. Pharmacokinetics, safety and tolerability of Bencycloquidium bromide, a novel selective muscarinic M1/M3 receptor antagonist, after single and multiple intranasal doses in healthy chinese subjects: an open-label, single-center, first-in-human study. Drugs R D. 2012 Mar 1;12(1):17-28. doi: 10.2165/11599330-000000000-00000. PubMed PMID: 22339483; PubMed Central PMCID: PMC3585954.

6: Cao R, Dong XW, Jiang JX, Yan XF, He JS, Deng YM, Li FF, Bao MJ, Xie YC, Chen XP, Xie QM. M(3) muscarinic receptor antagonist bencycloquidium bromide attenuates allergic airway inflammation, hyperresponsiveness and remodeling in mice. Eur J Pharmacol. 2011 Mar 25;655(1-3):83-90. doi: 10.1016/j.ejphar.2011.01.024. Epub 2011 Jan 28. PubMed PMID: 21277298.7: Jiang JX, Cao R, Deng WD, Jin F, Dong XW, Zhu Y, Chen XP, Xie YC, Bao MJ, Li FF, Xie QM. Characterization of bencycloquidium bromide, a novel muscarinic M(3) receptor antagonist in guinea pig airways. Eur J Pharmacol. 2011 Mar 25;655(1-3):74-82. doi: 10.1016/j.ejphar.2011.01.017. Epub 2011 Jan 24. PubMed PMID: 21272572.8: Li J, He H, Zhou Y, Yuan P, Chen X. Subchronic toxicity and toxicokinetics of long-term intranasal administration of bencycloquidium bromide: a 91-day study in dogs. Regul Toxicol Pharmacol. 2011 Mar;59(2):343-52. doi: 10.1016/j.yrtph.2010.11.006. Epub 2010 Dec 2. PubMed PMID: 21130130.9: Jiang B, Ruan Z, Lou H, Dong X, Xie Q. Determination of bencycloquidium bromide in dog plasma by liquid chromatography with electrospray ionization tandem mass spectrometry. Biomed Chromatogr. 2010 May;24(5):490-6. doi: 10.1002/bmc.1316. PubMed PMID: 19688815.10: Zhou W, Ding L, Xu G, Wang Y, Sun L, He J, Huang Y, Hu L, Chen X. Determination of bencycloquidium bromide in human urine using weak cation-exchange solid-phase extraction and LC-ESI-MS: Method validation and application to kinetic study of urinary excretion. J Pharm Biomed Anal. 2009 Aug 15;50(1):35-40. doi: 10.1016/j.jpba.2009.03.012. Epub 2009 Mar 24. PubMed PMID: 19395213.1

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