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AU 1421

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names：
5-Methyl-2-(2-(1-naphthyl)ethenyl)-4-piperidinopyridine hydrochloride
CAS號(hào)：
115717-83-4
MDL Number：
MF(分子式)： C23H25ClN2 MW(分子量)： 364.92
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文別名	AU 1421
英文別名	AU 1421, AU1421, AU-1421
CAS號(hào)	115717-83-4
Inchi	1S/C23H24N2.ClH/c1-18-17-24-21(16-23(18)25-14-5-2-6-15-25)13-12-20-10-7-9-19-8-3-4-11-22(19)20;/h3-4,7-13,16-17H,2,5-6,14-15H2,1H3;1H/b13-12-;
InchiKey	FIRAEJACZMKMQE-USGGBSEESA-N
分子式 Formula	C23H25ClN2
分子量 Molecular Weight	364.92
溶解度Solubility
性狀	Solid powder
儲(chǔ)藏條件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

產(chǎn)品說(shuō)明	AU 1421(CAS:115717-83-4):僅限應(yīng)用于工業(yè)或者科學(xué)研究過(guò)程中非醫(yī)療目的，不應(yīng)用于人類或動(dòng)物的臨床診斷以及治過(guò)程療，該產(chǎn)品非藥用，非食用。
Introduction	AU 1421 is a K(+)-site-directed pyridine derivative which activates hydrolysis of the K(+)-sensitive phosphoenzyme of sarcoplasmic reticulum Ca(2+)-ATPase and inactivates that of K(+)-transporting ATPases.
Application1
Application2
Application3

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危險(xiǎn)性	Warning
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[1]Nagamune H, Fukushima Y, Takada J, Yoshida K, Unami A, Shimooka T, Terada H. The lipophilic weak base (Z)-5-methyl-2-[2-(1-naphthyl)ethenyl]-4-piperidinopyridine (AU-1421) is a potent protonophore type cationic uncoupler of oxidative phosphorylation in mitochondria. Biochim Biophys Acta. 1993 Mar 1;1141(2-3):231-7. PubMed PMID: 8382953.

[2]Fukushima Y, Asano S, Takada J. K(+)-site-directed pyridine derivative, AU-1421, activates hydrolysis of the K(+)-sensitive phosphoenzyme of sarcoplasmic reticulum Ca(2+)-ATPase and inactivates that of K(+)-transporting ATPases. Biochim Biophys Acta. 1992 Apr 29;1106(1):71-6. PubMed PMID: 1533792.

[3] Hioki Y, Takada J, Hidaka Y, Yano M. Environmental differences of a pyridine derivative (AU-1421)-access sites between (H+,K+)-ATPase and (Na+,K+)-ATPase. J Pharmacobiodyn. 1991 Mar;14(3):170-5. PubMed PMID: 1652636.

[4] Takada J, Hioki Y, Yano M. (Z)-5-methyl-2-[2-(1-naphthyl)ethenyl]-4-piperidinopyridine (AU-1421), calcium ions and ethylenediamine as the K(+)-site directed probe for Na+/K(+)-ATPase. Biochim Biophys Acta. 1990 Nov 15;1041(2):123-8. PubMed PMID: 2176105.

[5] Takada J. Reversible inhibition of sodium and potassium-dependent adenosine triphosphatase by the pyridine derivative, AU-1421 during turnover cycle. Biochem Pharmacol. 1990 Oct 1;40(7):1527-31. PubMed PMID: 2171532.

6: Hioki Y, Takada J, Hidaka Y, Takeshita H, Hosoi M, Yano M. A newly synthesized pyridine derivative, (Z)-5-methyl-2-[2-(1-naphthyl)ethenyl]-4-piperidinopyridine hydrochloride (AU-1421), as a reversible gastric proton pump inhibitor. Arch Int Pharmacodyn Ther. 1990 May-Jun;30

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