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Ara-fluorocytosine

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names：
1-beta-D-Arabinofuranosyl-5-fluorocytosine
CAS號(hào)：
4298-10-6
MDL Number：
MF(分子式)： C9H12FN3O5 MW(分子量)： 261.21
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文別名	Ara-fluorocytosine
英文別名	Ara-fluorocytosine; NSC 529180; NSC-529180; NSC529180
CAS號(hào)	4298-10-6
Inchi	InChI=1S/C9H12FN3O5/c10-3-1-13(9(17)12-7(3)11)8-6(16)5(15)4(2-14)18-8/h1,4-6,8,14-16H,2H2,(H2,11,12,17)/t4-,5-,6+,8-/m1/s1
InchiKey	STRZQWQNZQMHQR-MNCSTQPFSA-N
分子式 Formula	C9H12FN3O5
分子量 Molecular Weight	261.21
溶解度Solubility
性狀	Solid powder
儲(chǔ)藏條件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

產(chǎn)品說明	Ara-fluorocytosine(CAS:4298-10-6):僅限應(yīng)用于工業(yè)或者科學(xué)研究過程中非醫(yī)療目的，不應(yīng)用于人類或動(dòng)物的臨床診斷以及治過程療，該產(chǎn)品非藥用，非食用。
Introduction	Ara-fluorocytosine is a biochemical.
Application1
Application2
Application3

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危險(xiǎn)性	Warning
危險(xiǎn)性警示
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[1]Siddiqui MA, Driscoll JS, Marquez VE, Roth JS, Shirasaka T, Mitsuya H, Barchi JJ Jr, Kelley JA. Chemistry and anti-HIV properties of 2'-fluoro-2',3'-dideoxyarabinofuranosylpyrimidines. J Med Chem. 1992 Jun 12;35(12):2195-20[1]PubMed PMID: 1351945.

[2]Thaler M, Bacher J, O'Leary T, Pizzo PA. Evaluation of single-drug and combination antifungal therapy in an experimental model of candidiasis in rabbits with prolonged neutropenia. J Infect Dis. 1988 Jul;158(1):80-8. PubMed PMID: 3392423.

[3] Snyder RD, van Houten B, Regan JD. The inhibition of ultraviolet radiation-induced DNA repair in human diploid fibroblasts by arabinofuranosyl nucleosides. Chem Biol Interact. 1984 Jun;50(1):1-14. PubMed PMID: 6733802.

[4] Mertelsmann R, Drapkin RL, Gee TS, Kempin S, Passe S, Thaler HT, Arlin Z, Dowling M, Dufour P, McKenzie S, To L, Comacho E, Oettgen HF, Burchenal JH, Clarkson B. Treatment of acute nonlymphocytic leukemia in adults: response to 2,2-anhydro-1-B-D-arabinofuranosyl-5-fluorocytosine and thioguanine on the L-12 protocol. Cancer. 1981 Nov 15;48(10):2136-42. PubMed PMID: 6170414.

[5] Watanabe KA, Reichman U, Chu CK, Hollenberg DH, Fox JJ. Nucleosides. 116. 1-(beta-D-Xylofuranosyl)-5-fluorocytosines with a leaving group on the 3' position. Potential double-barreled masked precursors of anticancer nucleosides. J Med Chem. 1980 Oct;23(10):1088-94. PubMed PMID: 7420353.

6: Brugarolas A, Buesa JM, Lacave AJ, Gracia Marco M, Valle Pereda M. Phase I and II clinical study of anhydro-ara-5-fluorocytosine (AAFC) and ICRF-159 combination in adenocarcinoma of digestive origin. Cancer Clin Trials. 1978 Winter;1(4):289-95. PubMed PMID: 93030.7: Kreis W, Woodcock TM, Meyers MB, Carlevarini LA, Krakoff IH. Physiologic disposition of cytosine arabinoside and its derivatives in man. Cancer Treat Rep. 1977 Jul;61(4):723-6. PubMed PMID: 195729.8: Cook AF. Fluorinated Pyrimidine nucleosides. 1. Synthesis of a nitrogen analogue of the antitumor agent 2,2'-anhydro-1-beta-D-arabinofuranosyl-5-fluorocytosine hydrochloride. J Med Chem. 1977 Mar;20(3):344-8. PubMed PMID: 66315.9: Basler GA, Shapiro WR. Comparison of 2,2'-anhydro-1-beta-D-arabinofuranosyl-5-fluorocytosine and cytosine arabinoside in the treatment of murine brain tumor. Cancer Treat Rep. 1976 Jul;60(7):875-9. PubMed PMID: 64295.10: Schneyer CA, Galbraith WM. Evaluation of sialogogic action of cyclocytidine (NSC-145668) and anhydro-ara-5-fluorocytidine (NSC-166641). Cancer Chemother Rep. 1975 Sep-Oct;59(5):1019. PubMed PMID: 1203892.1

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