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Apaxifylline

NMR下載 COA and HPLC MSDS下載
names：
1H-Purine-2,6-dione, 3,7-dihydro-8-(3-oxocyclopentyl)-1,3-dipropyl-, (S)-
CAS號：
151581-23-6
MDL Number：
MF(分子式)： C16H22N4O3 MW(分子量)： 318.38
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文別名	Apaxifylline
英文別名	Apaxifylline
CAS號	151581-23-6
Inchi	1S/C16H22N4O3/c1-3-7-19-14-12(15(22)20(8-4-2)16(19)23)17-13(18-14)10-5-6-11(21)9-10/h10H,3-9H2,1-2H3,(H,17,18)/t10-/m0/s1
InchiKey	RUHGOZFOVBMWOO-JTQLQIEISA-N
分子式 Formula	C16H22N4O3
分子量 Molecular Weight	318.38
溶解度Solubility
性狀	Solid powder
儲藏條件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

產(chǎn)品說明	Apaxifylline(CAS:151581-23-6):僅限應(yīng)用于工業(yè)或者科學(xué)研究過程中非醫(yī)療目的，不應(yīng)用于人類或動物的臨床診斷以及治過程療，該產(chǎn)品非藥用，非食用。
Introduction	Apaxifylline is a selective Adenosine A1 antagonist.
Application1
Application2
Application3

警示圖
危險(xiǎn)性	Warning
危險(xiǎn)性警示
安全聲明
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[1]Zhou Y, Tong L, Chu X, Deng F, Tang J, Tang Y, Dai Y. The Adenosine A1 Receptor Antagonist DPCPX Inhibits Tumor Progression via the ERK/JNK Pathway in Renal Cell Carcinoma. Cell Physiol Biochem. 2017;43(2):733-742. doi: 10.1159/000481557. Epub 2017 Sep 27. PubMed PMID: 28950257.

[2]Dastjerdi MN, Rarani MZ, Valiani A, Mahmoudieh M. The effect of adenosine A1 receptor agonist and antagonist on p53 and caspase 3, 8, and 9 expression and apoptosis rate in MCF-7 breast cancer cell line. Res Pharm Sci. 2016 Jul;11(4):303-10. doi: 10.4103/1735-5362.189301. PubMed PMID: 27651810; PubMed Central PMCID: PMC5022378.

[3] Zhai W, Chen D, Shen H, Chen Z, Li H, Yu Z, Chen G. A1 adenosine receptor attenuates intracerebral hemorrhage-induced secondary brain injury in rats by activating the P38-MAPKAP2-Hsp27 pathway. Mol Brain. 2016 Jun 14;9(1):66. doi: 10.1186/s13041-016-0247-x. PubMed PMID: 27301321; PubMed Central PMCID: PMC4908780.

[4] Dastjerdi MN, Valiani A, Mardani M, Ra MZ. Adenosine A1 receptor modifies P53 expression and apoptosis in breast cancer cell line Mcf-7. Bratisl Lek Listy. 2016;117(4):242-6. PubMed PMID: 27075390.

[5] Searl TJ, Dynda DI, Alanee SR, El-Zawahry AM, McVary KT, Silinsky EM. A1 Adenosine Receptor-Mediated Inhibition of Parasympathetic Neuromuscular Transmission in Human and Murine Urinary Bladder. J Pharmacol Exp Ther. 2016 Jan;356(1):116-22. doi: 10.1124/jpet.115.228882. Epub 2015 Nov 3. PubMed PMID: 26534943; PubMed Central PMCID: PMC4702072.

6: Kusek J, Yang Q, Witek M, Gruber CW, Nanoff C, Freissmuth M. Chaperoning of the A1-adenosine receptor by endogenous adenosine - an extension of the retaliatory metabolite concept. Mol Pharmacol. 2015 Jan;87(1):39-51. doi: 10.1124/mol.114.094045. Epub 2014 Oct 29. PubMed PMID: 25354767; PubMed Central PMCID: PMC4513639.7: Nascimento FP, Macedo-Júnior SJ, Pamplona FA, Luiz-Cerutti M, Córdova MM, Constantino L, Tasca CI, Dutra RC, Calixto JB, Reid A, Sawynok J, Santos AR. Adenosine A1 receptor-dependent antinociception induced by inosine in mice: pharmacological, genetic and biochemical aspects. Mol Neurobiol. 2015;51(3):1368-78. doi: 10.1007/s12035-014-8815-5. Epub 2014 Jul 27. PubMed PMID: 25064055.

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SDS 1.0 中文

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