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Anonaine

NMR下載 COA and HPLC MSDS下載
names：
5H-Benzo(g)-1,3-benzodioxolo(6,5,4-de)quinoline, 6,7,7a,8-tetrahydro-, (R)-
CAS號(hào)：
1862-41-5
MDL Number：
MF(分子式)： C17H15NO2 MW(分子量)： 265.31
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文別名	Anonaine
英文別名	Anonaine, Anonain
CAS號(hào)	1862-41-5
Inchi	1S/C17H15NO2/c1-2-4-12-10(3-1)7-13-15-11(5-6-18-13)8-14-17(16(12)15)20-9-19-14/h1-4,8,13,18H,5-7,9H2/t13-/m1/s1
InchiKey	VZTUKBKUWSHDFM-CYBMUJFWSA-N
分子式 Formula	C17H15NO2
分子量 Molecular Weight	265.31
溶解度Solubility
性狀	Solid powder
儲(chǔ)藏條件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

產(chǎn)品說明	Anonaine(CAS:1862-41-5):僅限應(yīng)用于工業(yè)或者科學(xué)研究過程中非醫(yī)療目的，不應(yīng)用于人類或動(dòng)物的臨床診斷以及治過程療，該產(chǎn)品非藥用，非食用。
Introduction	Anonaine is a bioactive benzylisoquinoline alkaloid, present in members of the plant families Magnoliaceae and Annonaceae. Anonaine is known to inhibit growth in human cervical cancer and lung carcinoma H1299 cells. Apoptosis in these cells is believed to occur by generation of nitric oxide and reactive oxygen species, reduction in intracellular glutathione concentration, activation of caspases and apoptosis-related proteins, and damage to DNA.
Application1
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[1]Li HT, Wu HM, Chen HL, Liu CM, Chen CY. The pharmacological activities of (-)-anonaine. Molecules. 2013 Jul 12;18(7):8257-63. doi: 10.3390/molecules18078257. Review. PubMed PMID: 23857128.

[2]Chen BH, Chang HW, Huang HM, Chong IW, Chen JS, Chen CY, Wang HM. (-)-Anonaine induces DNA damage and inhibits growth and migration of human lung carcinoma h1299 cells. J Agric Food Chem. 2011 Mar 23;59(6):2284-90. doi: 10.1021/jf103488j. Epub 2011 Mar 1. PubMed PMID: 21361287.

[3] Chen CY, Liu TZ, Tseng WC, Lu FJ, Hung RP, Chen CH, Chen CH. (-)-Anonaine induces apoptosis through Bax- and caspase-dependent pathways in human cervical cancer (HeLa) cells. Food Chem Toxicol. 2008 Aug;46(8):2694-702. doi: 10.1016/j.fct.2008.04.024. Epub 2008 Apr 27. PubMed PMID: 18524447.

[4] Lee JJ, Jin CM, Kim YK, Ryu SY, Lim SC, Lee MK. Effects of anonaine on dopamine biosynthesis and L-DOPA-induced cytotoxicity in PC12 cells. Molecules. 2008 Feb 27;13(2):475-87. PubMed PMID: 18305432.

[5] Valiente M, D'Ocon P, Noguera MA, Cassels BK, Lugnier C, Ivorra MD. Vascular activity of (-)-anonaine, (-)-roemerine and (-)-pukateine, three natural 6a(R)-1,2-methylenedioxyaporphines with different affinities for alpha1-adrenoceptor subtypes. Planta Med. 2004 Jul;70(7):603-9. PubMed PMID: 15254852.

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