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Alclofenac lysinate

NMR下載 COA and HPLC MSDS下載
names：
Benzeneacetic acid, 3-chloro-4-(2-propenyloxy)-, compd. with L-lysine (11)
CAS號(hào)：
59960-34-8
MDL Number：
MF(分子式)： C17H25ClN2O5 MW(分子量)： 372.846
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文別名	Alclofenac lysinate
英文別名	Alclofenac lysinate
CAS號(hào)	59960-34-8
Inchi	InChI=1S/C11H11ClO3.C6H14N2O2/c1-2-5-15-10-4-3-8(6-9(10)12)7-11(13)14;7-4-2-1-3-5(8)6(9)10/h2-4,6H,1,5,7H2,(H,13,14);5H,1-4,7-8H2,(H,9,10)/t;5-/m.0/s1
InchiKey	YDINFUGJNRFTDV-ZSCHJXSPSA-N
分子式 Formula	C17H25ClN2O5
分子量 Molecular Weight	372.846
溶解度Solubility
性狀	Solid powder
儲(chǔ)藏條件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

產(chǎn)品說明	Alclofenac lysinate(CAS:59960-34-8):僅限應(yīng)用于工業(yè)或者科學(xué)研究過程中非醫(yī)療目的，不應(yīng)用于人類或動(dòng)物的臨床診斷以及治過程療，該產(chǎn)品非藥用，非食用。
Introduction	Alclofenac is an anti-inflammatory agent used in the treatment of rheumatoid arthritis; acts also as an analgesic and an antipyretic.
Application1
Application2
Application3

警示圖
危險(xiǎn)性	Warning
危險(xiǎn)性警示
安全聲明
安全防護(hù)
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[1]Knights KM, Winner LK, Elliot DJ, Bowalgaha K, Miners JO. Aldosterone glucuronidation by human liver and kidney microsomes and recombinant UDP-glucuronosyltransferases: inhibition by NSAIDs. Br J Clin Pharmacol. 2009 Sep;68(3):402-12. doi: 10.1111/j.1365-2125.2009.03469.x. PubMed PMID: 19740398; PubMed Central PMCID: PMC2766480.

[2]Grimes DA, Hubacher D, Lopez LM, Schulz KF. Non-steroidal anti-inflammatory drugs for heavy bleeding or pain associated with intrauterine-device use. Cochrane Database Syst Rev. 2006 Oct 18;(4):CD006034. Review. PubMed PMID: 17054271.

[3] Selinsky BS, Gupta K, Sharkey CT, Loll PJ. Structural analysis of NSAID binding by prostaglandin H2 synthase: time-dependent and time-independent inhibitors elicit identical enzyme conformations. Biochemistry. 2001 May 1;40(17):5172-80. PubMed PMID: 11318639.

[4] Fillet M, Bechet I, Piette V, Crommen J. Separation of nonsteroidal anti-inflammatory drugs by capillary electrophoresis using nonaqueous electrolytes. Electrophoresis. 1999 Jul;20(9):1907-15. PubMed PMID: 10445335.

[5] Delbeke FT, Landuyt J, Debackere M. Disposition of human drug preparations in the horse. III. Orally administered alclofenac. J Vet Pharmacol Ther. 1994 Oct;17(5):353-8. PubMed PMID: 7853459.

6: Lee CK, Uchida T, Kitagawa K, Yagi A, Kim NS, Goto S. Effect of hydrophilic and lipophilic vehicles on skin permeation of tegafur, alclofenac and ibuprofen with or without permeation enhancers. Biol Pharm Bull. 1993 Dec;16(12):1264-9. PubMed PMID: 7907514.7: Delbeke FT, Landuyt J, Debackere M. Determination of alclofenac in equine plasma and urine by high-performance liquid chromatography. J Chromatogr. 1993 Nov 24;621(2):209-14. PubMed PMID: 7905004.8: Uchida T, Lee CK, Sekiya N, Goto S. Enhancement effect of an ethanol/Panasate 800 binary vehicle on anti-inflammatory drug permeation across excised hairless mouse skin. Biol Pharm Bull. 1993 Feb;16(2):168-71. PubMed PMID: 8364453.9: Kamiya Y, Nakabayashi K, Suzuki M, Motohashi S, Maemura C, Kitamoto K, Nagasawa T. [A case of concurrent occurrence of acute renal failure and nephrotic syndrome induced by alclofenac]. Nihon Naika Gakkai Zasshi. 1989 Jul;78(7):958-63. Japanese. PubMed PMID: 2571652.10: de Jong EG, Kiffers J, Maes RA. The determination of non-steroidal anti-inflammatory drugs by GC-MS-MS in equine urine. J Pharm Biomed Anal. 1989;7(12):1617-22. PubMed PMID: 2490551.1

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