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Alacepril

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names：
(3-(acetylthio)-2-methylpropanoyl)-L-prolyl-L-phenylalanine
CAS號：
74258-86-9
MDL Number：
MF(分子式)： C20H26N2O5S MW(分子量)： 406.497
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文別名	Alacepril
英文別名	Alacepril; DU-1219; DU 1219; DU1219; Cetapril; Alaceprilum
CAS號	74258-86-9
Inchi	InChI=1S/C20H26N2O5S/c1-13(12-28-14(2)23)19(25)22-10-6-9-17(22)18(24)21-16(20(26)27)11-15-7-4-3-5-8-15/h3-5,7-8,13,16-17H,6,9-12H2,1-2H3,(H,21,24)(H,26,27)/t13?,16-,17-/m0/s1
InchiKey	FHHHOYXPRDYHEZ-LMARGRMVSA-N
分子式 Formula	C20H26N2O5S
分子量 Molecular Weight	406.497
溶解度Solubility
性狀	Solid powder
儲藏條件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

產(chǎn)品說明	Alacepril(CAS:74258-86-9):僅限應用于工業(yè)或者科學研究過程中非醫(yī)療目的，不應用于人類或動物的臨床診斷以及治過程療，該產(chǎn)品非藥用，非食用。
Introduction	Alacepril, also known as Cetapril and DU-1219, is an angiotensin-converting enzyme inhibitor and is commonly used as an antihypertensive.
Application1
Application2
Application3

警示圖
危險性	Warning
危險性警示
安全聲明
安全防護
備注

[1]Sakatani A, Miyagawa Y, Takemura N. Evaluation of the effect of an angiotensin-converting enzyme inhibitor, alacepril, on drug-induced renin-angiotensin-aldosterone system activation in normal dogs. J Vet Cardiol. 2016 Sep;18(3):248-54. doi: 10.1016/j.jvc.2016.05.00[1]PubMed PMID: 27364087.

[2]Sugimoto K, Fujii Y, Takubo I, Shiga T, Sunahara H, Aoki T, Orito K. Pharmacodynamics of alacepril in healthy cats. J Feline Med Surg. 2016 Feb 29. pii: 1098612X16636420. [Epub ahead of print] PubMed PMID: 26927816.

[3] Nonoguchi H, Kiyama S, Kitamura K, Naruse M, Tomita M, Tazoe N, Tajiri M, Nakayama Y, Kohda Y, Inoue T, Tomita K. Long-term plasma levels and dose modulation of alacepril in patients with chronic renal failure. Hypertens Res. 2008 Jan;31(1):29-36. doi: 10.1291/hypres.31.29. PubMed PMID: 18360015.

[4] Katoh H, Itagaki T, Suzuki K, Obata Y, Adachi Y, Doi M, Sato S. [Successful extubation in a patient with alacepril-induced tongue angioedema]. Masui. 2010 Apr;59(4):519-22. Japanese. PubMed PMID: 20420150.

[5] Usui S, Kubota M, Iguchi K, Kiho T, Sugiyama T, Katagiri Y, Hirano K. Sialic acid 9-O-acetylesterase catalyzes the hydrolyzing reaction from alacepril to deacetylalacepril. Pharm Res. 2003 Aug;20(8):1309-16. PubMed PMID: 12948030.

6: Shimozawa M, Naito Y, Manabe H, Uchiyama K, Katada K, Kuroda M, Nakabe N, Yoshida N, Yoshikawa T. The inhibitory effect of alacepril, an angiotensin-converting enzyme inhibitor, on endothelial inflammatory response induced by oxysterol and TNF-alpha. Redox Rep. 2004;9(6):354-9. PubMed PMID: 15720832.7: Kinugawa T, Osaki S, Kato M, Ogino K, Shimoyama M, Tomikura Y, Igawa O, Hisatome I, Shigemasa C. Effects of the angiotensin-converting enzyme inhibitor alacepril on exercise capacity and neurohormonal factors in patients with mild-to-moderate heart failure. Clin Exp Pharmacol Physiol. 2002 Dec;29(12):1060-5. PubMed PMID: 12390293.8: Osaki S, Kinugawa T, Ogino K, Kato M, Furuse Y, Tomikura Y, Igawa O, Hisatome, Shigemasa C. Effects of acute and chronic alacepril treatment on exercise capacity and hemodynamics in patients with heart failure: a preliminary study. Int J Clin Pharmacol Ther. 2002 Feb;40(2):69-74. PubMed PMID: 11862975.9: Atarashi K, Takagi M, Minami M, Ishiyama A. Effects of alacepril and amlodipine on the renal injury induced by a high-cholesterol diet in rats. J Hypertens. 1999 Dec;17(12 Pt 2):1983-6. PubMed PMID: 10703899.10: Miyazaki M, Takai S. Antiatherosclerotic effect of alacepril, an angiotensin-converting enzyme inhibitor, in monkeys fed a high-cholesterol diet. Hypertens Res. 1999 Mar;22(1):49-54. PubMed PMID: 10221351.1

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