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7-Deazainosine

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names：
4H-Pyrrolo(2,3-d)pyrimidin-4-one, 1,7-dihydro-7-beta-D-ribofuranosyl- (8CI)(9CI)
CAS號：
2862-16-0
MDL Number：
MF(分子式)： C11H13N3O5 MW(分子量)： 267.24
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文別名	7-Deazainosine
英文別名	7-Deazainosine; Deaminohydroxytubercindin; 7 Deazainosine; 7Deazainosine.
CAS號	2862-16-0
Inchi	InChI=1S/C11H13N3O5/c15-3-6-7(16)8(17)11(19-6)14-2-1-5-9(14)12-4-13-10(5)18/h1-2,4,6-8,11,15-17H,3H2,(H,12,13,18)/t6-,7-,8-,11-/m1/s1
InchiKey	DPRSKJHWKNHBOW-KCGFPETGSA-N
分子式 Formula	C11H13N3O5
分子量 Molecular Weight	267.24
溶解度Solubility
性狀	Solid powder
儲藏條件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

產(chǎn)品說明	7-Deazainosine(CAS:2862-16-0):僅限應(yīng)用于工業(yè)或者科學(xué)研究過程中非醫(yī)療目的，不應(yīng)用于人類或動物的臨床診斷以及治過程療，該產(chǎn)品非藥用，非食用。
Introduction	7-Deazainosine is a biochemical.
Application1
Application2
Application3

警示圖
危險性	Warning
危險性警示
安全聲明
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[1]Leonard P, Ingale SA, Ding P, Ming X, Seela F. Studies on the glycosylation of pyrrolo[2,3-d] pyrimidines with 1-O-acetyl-2,3,5-tri-O-benzoyl-beta-D-ribofuranose: the formation of regioisomers during toyocamycin and 7-deazainosine syntheses. Nucleosides Nucleotides Nucleic Acids. 2009 May;28(5):678-94. doi: 10.1080/15257770903091953. PubMed PMID: 20183609.

[2]Al Safarjalani ON, Rais RH, Kim YA, Chu CK, Naguib FN, el Kouni MH. 7-Deaza-6-benzylthioinosine analogues as subversive substrate of Toxoplasma gondii adenosine kinase: activities and selective toxicities. Biochem Pharmacol. 2008 Oct 15;76(8):958-66. doi: 10.1016/j.bcp.2008.07.035. Epub 2008 Aug 7. PubMed PMID: 18755159; PubMed Central PMCID: PMC2581922.

[3] Ciliberti N, Durini E, Manfredini S, Vertuani S. 7-deazainosine derivatives: synthesis and characterization of 7- and 7,8-substituted pyrrolo [2,3-d]pyrimidine ribonucleosides. Nucleosides Nucleotides Nucleic Acids. 2008 May;27(5):525-33. doi: 10.1080/15257770802089009. PubMed PMID: 18569790.

[4] Moreau C, Wagner GK, Weber K, Guse AH, Potter BV. Structural determinants for N1/N7 cyclization of nicotinamide hypoxanthine 5'-dinucleotide (NHD+) derivatives by ADP-ribosyl cyclase from aplysia californica: Ca2+-mobilizing activity of 8-substituted cyclic inosine 5'-diphosphoribose analogues in T-lymphocytes. J Med Chem. 2006 Aug 24;49(17):5162-76. PubMed PMID: 16913705.

[5] Mao C, Cook WJ, Zhou M, Federov AA, Almo SC, Ealick SE. Calf spleen purine nucleoside phosphorylase complexed with substrates and substrate analogues. Biochemistry. 1998 May 19;37(20):7135-46. PubMed PMID: 9585525.

6: Hirota K, Monguchi Y, Sako M, Kitade Y. Substitution effect of purine nucleosides on diisobutylaluminum hybride reduction. Nucleic Acids Symp Ser. 1995;(34):15-6. PubMed PMID: 8841529.7: Kim J, Pordesimo EO, Toth SI, Schmitz FJ, Van Altena I. Pantherinine, a cytotoxic aromatic alkaloid, and 7-deazainosine from the ascidian Aplidium pantherinum. J Nat Prod. 1993 Oct;56(10):1813-6. PubMed PMID: 8277319.8: Kim SH, Okazaki K, Okabe T, Nishimura T, Kondo T, Tanaka N, Suzuki H. Structure-activity relationships of cadeguomycin analogs. J Antibiot (Tokyo). 1991 Jun;44(6):659-64. PubMed PMID: 2071491.9: Bzowska A, Kulikowska E, Shugar D. Properties of purine nucleoside phosphorylase (PNP) of mammalian and bacterial origin. Z Naturforsch C. 1990 Jan-Feb;45(1-2):59-70. PubMed PMID: 2109978.10: Wood SG, Ubasawa A, Martin D, Jiricny J. Guanine and adenine analogues as tools in the investigation of the mechanisms of mismatch repair in E. coli. Nucleic Acids Res. 1986 Aug 26;14(16):6591-602. PubMed PMID: 3529037; PubMed Central PMCID: PMC311666.1

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