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Didesmethylrocaglamide

NMR下載 COA and HPLC MSDS下載
names：
(1R,2R,3S,3aR,8bS)-2,3,3a,8b-Tetrahydro-1,8b-dihydroxy-6,8-dimethoxy-3a-(4-methoxyphenyl)-3-phenyl-1H-cyclopenta[b]benzofuran-2-carboxamide
CAS號(hào)：
177262-30-5
MDL Number：
MF(分子式)： C27H27NO7 MW(分子量)： 477.513
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文別名	Didesmethylrocaglamide
英文別名	Didesmethylrocaglamide; DDR; rocaglamide-derivative.
CAS號(hào)	177262-30-5
Inchi	InChI=1S/C27H27NO7/c1-32-17-11-9-16(10-12-17)27-22(15-7-5-4-6-8-15)21(25(28)30)24(29)26(27,31)23-19(34-3)13-18(33-2)14-20(23)35-27/h4-14,21-22,24,29,31H,1-3H3,(H2,28,30)/t21-,22-,24-,26+,27+/m1/s1
InchiKey	RMNPQEWLGQURNX-PXIJUOARSA-N
分子式 Formula	C27H27NO7
分子量 Molecular Weight	477.513
溶解度Solubility
性狀	Solid powder
儲(chǔ)藏條件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

產(chǎn)品說(shuō)明	Didesmethylrocaglamide(CAS:177262-30-5):僅限應(yīng)用于工業(yè)或者科學(xué)研究過(guò)程中非醫(yī)療目的，不應(yīng)用于人類或動(dòng)物的臨床診斷以及治過(guò)程療，該產(chǎn)品非藥用，非食用。
Introduction	Didesmethylrocaglamide is a naturally occurring 1H-cyclopenta[b]benzofuran lignans of the rocaglamide type isolated from three Aglaia species (Aglaia duperreana, A. oligophylla and A. spectabilis). Didesmethylrocaglamide inhibited cell growth in a similar concentration range as the well-known anticancer drug vinblastine sulfate. Didesmethylrocaglamide arrested MPNST cells at G2-M, increased the sub-G1 population, induced cleavage of caspases and PARP, and elevated the levels of the DNA-damage response marker γH2A.X, while decreasing the expression of AKT and ERK1/2, consistent with translation inhibition.
Application1
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警示圖
危險(xiǎn)性	Warning
危險(xiǎn)性警示
安全聲明
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[1]Chang LS, Oblinger JL, Burns SS, Huang J, Anderson LW, Hollingshead MG, Shen R, Pan L, Agarwal G, Ren Y, Roberts RD, O'Keefe BR, Kinghorn AD, Collins JM. Targeting Protein Translation by Rocaglamide and Didesmethylrocaglamide to Treat MPNST and Other Sarcomas. Mol Cancer Ther. 2020 Mar;19(3):731-74[1]doi: 10.1158/1535-7163.MCT-19-0809. Epub 2019 Dec 17. PMID: 31848295; PMCID: PMC7056570.

[2]Bohnenstengel FI, Steube KG, Meyer C, Quentmeier H, Nugroho BW, Proksch P. 1H-cyclopenta[b]benzofuran lignans from Aglaia species inhibit cell proliferation and alter cell cycle distribution in human monocytic leukemia cell lines. Z Naturforsch C J Biosci. 1999 Dec;54(12):1075-83. doi: 10.1515/znc-1999-1212. PMID: 10685499.

[3] Bohnenstengel FI, Steube KG, Meyer C, Nugroho BW, Hung PD, Kiet LC, Proksch P. Structure activity relationships of antiproliferative rocaglamide derivatives from Aglaia species (Meliaceae). Z Naturforsch C J Biosci. 1999 Jan- Feb;54(1-2):55-60. PMID: 10223787.

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