購物車 
-
Forasartan
- names：
5-[(3,5-dibutyl-1,2,4-triazol-1-yl)methyl]-2-[2-(2H-tetrazol-5-yl)phenyl]pyridine
- CAS號：
145216-43-9
MDL Number： - MF(分子式)： C23H28N8 MW(分子量)： 416.52
- EINECS: Reaxys Number:
- Pubchem ID: Brand:BIOFOUNT
| 貨品編碼 | 規(guī)格 | 純度 | 價(jià)格 (￥) | 現(xiàn)價(jià)(￥) | 特價(jià)(￥) | 庫存描述 | 數(shù)量 | 總計(jì) (￥) |
|---|
- 大包裝詢價(jià) 提供各種包裝，敬請垂詢
- 收藏商品 商品點(diǎn)評 加入購物車 立即購買
| 中文別名 | Forasartan |
| 英文別名 | Forasartan; SC-52458; SC 52458; SC52458. |
| CAS號 | 145216-43-9 |
| Inchi | InChI=1S/C23H28N8/c1-3-5-11-21-25-22(12-6-4-2)31(28-21)16-17-13-14-20(24-15-17)18-9-7-8-10-19(18)23-26-29-30-27-23/h7-10,13-15H,3-6,11-12,16H2,1-2H3,(H,26,27,29,30) |
| InchiKey | YONOBYIBNBCDSJ-UHFFFAOYSA-N |
| 分子式 Formula | C23H28N8 |
| 分子量 Molecular Weight | 416.52 |
| 溶解度Solubility | |
| 性狀 | Solid powder |
| 儲藏條件 Storage conditions | Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years). |
| 產(chǎn)品說明 | Forasartan(CAS:145216-43-9):僅限應(yīng)用于工業(yè)或者科學(xué)研究過程中非醫(yī)療目的，不應(yīng)用于人類或動物的臨床診斷以及治過程療，該產(chǎn)品非藥用，非食用。 |
| Introduction | Forasartan is a nonpeptide angiotensin II receptor antagonist with antihypertensive activity. Forasartan competes with angiotensin II for binding at the AT1 receptor subtype in vascular smooth muscle, thereby blocking angiotensin II-mediated vasoconstriction resulting in vascular dilatation. In addition, the antagonistic effect on AT1 in the adrenal gland, prevents angiotensin II-induced stimulation of aldosterone synthesis and secretion by the adrenal cortex. |
| Application1 | |
| Application2 | |
| Application3 |
| [1]Kushiku K, Yamada H, Shibata K, Tokunaga R, Katsuragi T, Furukawa T.Upregulation of immunoreactive angiotensin II release and angiotensinogen mRNAexpression by high-frequency preganglionic stimulation at the canine cardiacsympathetic ganglia. Circ Res. 2001 Jan 19;88(1):110-6. PubMed PMID: 11139482. |
| [2]Aki Y, Tomohiro A, Nishiyama A, Kiyomoto K, Kimura S, Abe Y. The role ofbasally synthesized nitric oxide in modulating the renal vasoconstrictor actionof angiotensin II. Hypertens Res. 1997 Dec;20(4):251-6. PubMed PMID: 9453259. |
| [3] McMahon EG, Yang PC, Babler MA, Suleymanov OD, Palomo MA, Olins GM, Cook CS.Effects of SC-52458, an angiotensin AT1 receptor antagonist, in the dog. Am JHypertens. 1997 Jun;10(6):671-7. PubMed PMID: 9194514. |
| [4] Usune S, Furukawa T. Effects of SC-52458, a new nonpeptide angiotensin IIreceptor antagonist, on increase in cytoplasmic Ca2+ concentrations andcontraction induced by angiotensin II and K(+)-depolarization in guinea-pigtaenia coli. Gen Pharmacol. 1996 Oct;27(7):1179-85. PubMed PMID: 8981065. |
| [5] Ohta K, Kim S, Hamaguchi A, Yukimura T, Miura K, Takaori K, Iwao H. Role ofangiotensin II in extracellular matrix and transforming growth factor-beta 1expression in hypertensive rats. Eur J Pharmacol. 1994 Sep 15;269(1):115-9.PubMed PMID: 7828653. |
6: Olins GM, Corpus VM, Chen ST, McMahon EG, Palomo MA, McGraw DE, Smits GJ, NullCL, Brown MA, Bittner SE, et al. Pharmacology of SC-52458, an orally active,nonpeptide angiotensin AT1 receptor antagonist. J Cardiovasc Pharmacol. 1993Oct;22(4):617-25. PubMed PMID: 7505365.7: de la Hoz JC. [Bee (Apis mellifera, Hymenoptera: Apoidea) visitation tocantaloupe Cucumis melo (Cucurvitaceae) flowers in Panama]. Rev Biol Trop. 2007Jun;55(2):677-80. Spanish. PubMed PMID: 19069779.8: Krovat EM, Langer T. Non-peptide angiotensin II receptor antagonists: chemicalfeature based pharmacophore identification. J Med Chem. 2003 Feb 27;46(5):716-26.PubMed PMID: 12593652.9: Katsuragi T, Sato C, Guangyuan L, Honda K. Inositol(1,4,5)trisphosphate signaltriggers a receptor-mediated ATP release. Biochem Biophys Res Commun. 2002 May3;293(2):686-90. PubMed PMID: 12054523.10: Hagmann M, Nussberger J, Naudin RB, Burns TS, Karim A, Waeber B, Brunner HR.SC-52458, an orally active angiotensin II-receptor antagonist: inhibition ofblood pressure response to angiotensin II challenges and pharmacokinetics innormal volunteers. J Cardiovasc Pharmacol. 1997 Apr;29(4):444-50. PubMed PMID:9156352.1
對不起，暫無產(chǎn)品評價(jià)！
MSDS
SDS 1.0 中文
展開
SDS 1.0 英文
展開
- 相關(guān)產(chǎn)品
-
< >
- 推薦產(chǎn)品
-
< >
- 最新產(chǎn)品
-
< >
新聞
胞爬片免疫組化染色.png)
怎么做細(xì)胞爬片免疫組化染色實(shí)驗(yàn)
細(xì)胞爬片免疫組化染色，是通過細(xì)胞爬片是讓玻片浸在細(xì)胞培養(yǎng)基內(nèi)，細(xì)胞在玻片上生長，主要用于組織學(xué)，免疫組織化學(xué)...
2020/7/20 22:04:33
提取病毒RNA的實(shí)驗(yàn)方法
提取病毒RNA方法分別有：異硫氰酸胍的提取病毒RNA方法、TRIzol LS提取法、Trizol法提取法等等...
2020/7/22 20:29:26
chelex 100樹脂國產(chǎn)替代之路-BIOFOUNT范德生物
Chelex 100螯合離子交換樹脂對銅、鐵和其他重金屬?的偏好顯著高于對鈉、鉀等一價(jià)陽離子的偏好。它對二價(jià)...
2025/11/4 14:22:46
9月開學(xué)季——助研新學(xué)期 范德送好禮
2025/8/28 15:30:55
Waxfilm 實(shí)驗(yàn)室封口膜：技術(shù)與國際市場的雙重突破
在實(shí)驗(yàn)室耗材領(lǐng)域，封口膜是保障實(shí)驗(yàn)準(zhǔn)確性與穩(wěn)定性的關(guān)鍵產(chǎn)品之一。近年來，Waxfilm?實(shí)驗(yàn)室封口膜憑借其卓...
2025/5/13 13:03:40
Waxfilm實(shí)驗(yàn)室封口膜的5大突破
Waxfilm實(shí)驗(yàn)室封口膜作為生物功能膜領(lǐng)域的國產(chǎn)技術(shù)突破和品牌突破，是生物領(lǐng)域中國技術(shù)發(fā)展的縮影。
2025/5/6 17:02:07
各種微流控芯片鍵合方法的優(yōu)缺點(diǎn)
微流控芯片鍵合：目前主要有激光焊接、熱壓鍵合、膠鍵合、超音波焊接，每種方法都有各自的優(yōu)缺點(diǎn)。本文主要介紹聚酯...
2023/7/28 10:43:09
新一代微流控鍵合解決方案
微流控鍵合解決方案：微流控芯片制造的一個(gè)重要環(huán)節(jié)，也是最容易被忽視的--芯片鍵合。其中一個(gè)重要因素是：微流控...
2023/7/27 12:44:28
驗(yàn)動物圖.png)
熒光素鉀鹽使用說明
D-熒光素鉀鹽（K+）設(shè)計(jì)用于體外和體內(nèi)生物發(fā)光測定。D-熒光素的質(zhì)量和純度對于獲得良好和可重復(fù)的結(jié)果至關(guān)重...
2023/7/20 11:05:11
如何選BSA（牛血清白蛋白）
如何選BSA（牛血清白蛋白）：牛血清白蛋白（BSA）有多種形式，如何選擇適合自己的牛血清白蛋白（BSA）是一...
2023/2/14 13:09:18
