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Estazolam

NMR下載 COA and HPLC MSDS下載
names：
8-chloro-6-phenyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine
CAS號(hào)：
29975-16-4
MDL Number：
MF(分子式)： C16H11ClN4 MW(分子量)： 294.74
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文別名	Estazolam
英文別名	Estazolam; Eurodin; Nuctalon; ProSom; Esilgan; Julodin; Nuctalon; ProSom; Takeda Brand of Estazolam; Tasedan;
CAS號(hào)	29975-16-4
Inchi	InChI=1S/C16H11ClN4/c17-12-6-7-14-13(8-12)16(11-4-2-1-3-5-11)18-9-15-20-19-10-21(14)15/h1-8,10H,9H2
InchiKey	CDCHDCWJMGXXRH-UHFFFAOYSA-N
分子式 Formula	C16H11ClN4
分子量 Molecular Weight	294.74
溶解度Solubility
性狀	Solid powder
儲(chǔ)藏條件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

產(chǎn)品說(shuō)明	Estazolam(CAS:29975-16-4):僅限應(yīng)用于工業(yè)或者科學(xué)研究過程中非醫(yī)療目的，不應(yīng)用于人類或動(dòng)物的臨床診斷以及治過程療，該產(chǎn)品非藥用，非食用。
Introduction	Estazolam is discontinued (DEA controlled substance). Estazolam is a benzodiazepine with anxiolytic, anticonvulsant, hypnotic, and muscle relaxant properties. Estazolam binds to the gamma-aminobutyric acid (GABA) receptor at a site distinct from the inhibitory neurotransmitter GABA binding site in the limbic system of the central nervous system.
Application1
Application2
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危險(xiǎn)性	Warning
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[1]Yen CF, Ko CH, Chang YP, Yu CY, Huang MF, Yeh YC, Lin JJ, Chen CS. Dependence,misuse, and beliefs regarding use of hypnotics by elderly psychiatric patientstaking zolpidem, estazolam, or flunitrazepam. Asia Pac Psychiatry. 2015Sep;7(3):298-305. doi: 10.1111/appy.12147. Epub 2014 Oct 8. PubMed PMID:25296384.

[2]Wang ZZ, Wang YP, Yang B, Wan JP, Wang J. Clinical efficacies of treatingrefractory insomnia patients with estazolam plus alternating current magneticfield. Chin Med J (Engl). 2012 Sep;125(17):3175-6. PubMed PMID: 22932202.

[3] Yuan JX, Wang YJ, Yun KM. [Stability of estazolam in dog tissues preserved informaldehyde solution]. Fa Yi Xue Za Zhi. 2011 Apr;27(2):117-9, 124. Chinese.PubMed PMID: 21604450.

[4] Bu J, Zhuo XY. [The influence of estazolam on human neurobehavioral function].Fa Yi Xue Za Zhi. 2010 Feb;26(1):30-2. Chinese. PubMed PMID: 20232740.

[5] Li HC, Chen XG, Tian X. [Analysis on somnipathy related factors in elderlypatients with stroke and comparative study on the efficacy of treatment bytraditional Chinese medicine and by estazolam]. Zhongguo Zhong Xi Yi Jie He ZaZhi. 2009 Mar;29(3):204-7. Chinese. PubMed PMID: 19548433.

6: Harahap Y, Sasongko L, Prasaja B, Indriati E, Lusthom W, Lipin. Comparativebioavailability of two estazolam tablet formulations in Indonesian healthyvolunteers. Arzneimittelforschung. 2008;58(10):501-4. doi:10.1055/s-0031-1296548. PubMed PMID: 19025059.7: Miura M, Otani K, Ohkubo T. Identification of human cytochrome P450 enzymesinvolved in the formation of 4-hydroxyestazolam from estazolam. Xenobiotica. 2005May;35(5):455-65. PubMed PMID: 16012077.8: Aoshima T, Fukasawa T, Otsuji Y, Okuyama N, Gerstenberg G, Miura M, Ohkubo T,Sugawara K, Otani K. Effects of the CYP2C19 genotype and cigarette smoking on thesingle oral dose pharmacokinetics and pharmacodynamics of estazolam. ProgNeuropsychopharmacol Biol Psychiatry. 2003 May;27(3):535-8. PubMed PMID:12691790.9: Gu JK, Xia R, Zhong DF, Sun L. [Identification of estazolam, alprazolam andtriazolam in human urine by LC/MSn]. Yao Xue Xue Bao. 2002 Feb;37(2):138-40.Chinese. PubMed PMID: 12579961.10: Toyo'oka T, Kumaki Y, Kanbori M, Kato M, Nakahara Y. Determination ofhypnotic benzodiazepines (alprazolam, estazolam, and midazolam) and theirmetabolites in rat hair and plasma by reversed-phase liquid-chromatography withelectrospray ionization mass spectrometry. J Pharm Biomed Anal. 2003 Jan15;30(6):1773-87. PubMed PMID: 12485719.1

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