-
(Z)-9-丙烯基腺嘌呤
- names:
(Z)-9-Propenyladenine
- CAS號(hào):
1464851-21-5
MDL Number: - MF(分子式): C8H9N5 MW(分子量): 175.19
- EINECS: Reaxys Number:
- Pubchem ID:97304985 Brand:BIOFOUNT
| 貨品編碼 | 規(guī)格 | 純度 | 價(jià)格 (¥) | 現(xiàn)價(jià)(¥) | 特價(jià)(¥) | 庫存描述 | 數(shù)量 | 總計(jì) (¥) |
|---|---|---|---|---|---|---|---|---|
| YZM000694-5mg | 5mg | 97.8% | ¥ 3341.00 | ¥ 3341.00 | 2-3天 | ¥ 0.00 | ||
| YZM000694-1mg | 1mg | 97.8% | ¥ 1072.50 | ¥ 1072.50 | 2-3天 | ¥ 0.00 |
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| 中文別名 | (Z)-9-丙烯基腺嘌呤(1464851-21-5);(Z)-9-(丙-1-烯-1-基)-9H-嘌呤-6-胺;ZINC95936042;CS-6247;HY-100079A;9-[((Z)-1-丙烯基] -9H-嘌呤-6-胺; |
| 英文別名 | (Z)-9-Propenyladenine(1464851-21-5);(Z)-Mutagenic Impurity of Tenofovir Disoproxil;(Z)-9-(prop-1-en-1-yl)-9H-purin-6-amine;ZINC95936042;CS-6247;HY-100079A;9-[(Z)-1-Propenyl]-9H-purine-6-amine; |
| CAS號(hào) | 1464851-21-5 |
| Inchi | No data available |
| InchiKey | No data available |
| 分子式 Formula | C8H9N5 |
| 分子量 Molecular Weight | 175.19 |
| 溶解度Solubility | 生物體外In Vitro:DMSO溶解度≥ 31 mg/mL(176.95 mM)*"≥" means soluble可溶, but saturation unknown溶解度未知. |
| 性狀 | 固體粉末,Power |
| 儲(chǔ)藏條件 Storage conditions | -20°C 3 years年 4°C 2 years年 / In solvent溶液中:-80°C 6 months月 -20°C 1 month月 |
(Z)-9-丙烯基腺嘌呤(1464851-21-5,(Z)-9-Propenyladenine)實(shí)驗(yàn)注意事項(xiàng):
1.實(shí)驗(yàn)前需戴好防護(hù)眼鏡,穿戴防護(hù)服和口罩,佩戴手套,避免與皮膚接觸。
2.實(shí)驗(yàn)過程中如遇到有毒或者刺激性物質(zhì)及有害物質(zhì)產(chǎn)生,必要時(shí)實(shí)驗(yàn)操作需要手套箱內(nèi)完成以免對實(shí)驗(yàn)人員造成傷害
3.實(shí)驗(yàn)后產(chǎn)生的廢棄物需分類存儲(chǔ),并交于專業(yè)生物廢氣物處理公司處理,以免造成環(huán)境污染Experimental considerations:
1. Wear protective glasses, protective clothing and masks, gloves, and avoid contact with the skin during the experiment.
2. The waste generated after the experiment needs to be stored separately, and handed over to a professional biological waste gas treatment company to avoid environmental pollution.
Tags:(Z)-9-丙烯基腺嘌呤試劑,(Z)-9-丙烯基腺嘌呤雜質(zhì),(Z)-9-丙烯基腺嘌呤中間體,(Z)-9-丙烯基腺嘌呤密度,(Z)-9-丙烯基腺嘌呤溶解度,(Z)-9-丙烯基腺嘌呤旋光度,(Z)-9-丙烯基腺嘌呤閃點(diǎn),(Z)-9-丙烯基腺嘌呤結(jié)構(gòu)式,(Z)-9-丙烯基腺嘌呤購買,(Z)-9-丙烯基腺嘌呤MSDS,
| 產(chǎn)品說明 | (Z)-9-丙烯基腺嘌呤(1464851-21-5,(Z)-9-Propenyladenine)是富馬酸替諾福韋二吡呋酯中的誘變雜質(zhì) |
| Introduction | (Z)-9-丙烯基腺嘌呤(1464851-21-5,(Z)-9-Propenyladenine) is a mutagenic impurity in tenof ovir disoproxil fumarate. |
| Application1 | Tenof ovir is an antiretroviral drug known as nucleotide analogue reverse transcriptase (NtART) inhibitor, which blocks reverse transcriptase, a crucial virus enzyme in HIV and HBV. |
| Application2 | |
| Application3 |
(Z)-9-丙烯基腺嘌呤(1464851-21-5,(Z)-9-Propenyladenine)藥理學(xué):
(Z)-9-Propenyladenine 是富馬酸替諾福韋二吡呋酯中的誘變雜質(zhì)。替諾福韋是一種抗逆轉(zhuǎn)錄病毒藥物,是核苷酸類似物逆轉(zhuǎn)錄酶(NtART)抑制劑,能阻斷HIV-1和HBV的逆轉(zhuǎn)錄酶。
| 警示圖 | |
| 危險(xiǎn)性 | warning |
| 危險(xiǎn)性警示 | Not available |
| 安全聲明 | H303吞入可能有害+H313皮膚接觸可能有害+H2413吸入可能對身體有害 |
| 安全防護(hù) | P264處理后徹底清洗+P280戴防護(hù)手套/穿防護(hù)服/戴防護(hù)眼罩/戴防護(hù)面具+P305如果進(jìn)入眼睛+P351用水小心沖洗幾分鐘+P338取出隱形眼鏡(如果有)并且易于操作,繼續(xù)沖洗+P337如果眼睛刺激持續(xù)+P2393獲得醫(yī)療建議/護(hù)理 |
| 備注 | 實(shí)驗(yàn)過程中防止吸入、食入,做好安全防護(hù) |
| Preparation method of tenofovir intermediate Publication Number CN-106588932-A 2016-12-20 |
(Z)-9-丙烯基腺嘌呤(1464851-21-5,(Z)-9-Propenyladenine)參考文獻(xiàn):
1、Preparation method of tenofovir intermediate LYU YANHUA
Abstract The invention discloses a preparation method of a tenofovir intermediate. The preparation method comprises the following steps: 1, contacting and reacting adenine with (Z)-1-halopropylene in an organic solvent in the presence of hexamethylphosphoramide to obtain (Z)-9-propenyladenine; and 2, reacting the (Z)-9-propenyladenine with metachloroperbenzoic acid under the catalysis of a chiral catalyst to obtain the tenofovir intermediate (R)-9-(2-hydroxypropyl)adenine, wherein the chiral catalyst is D-(-)-tartaric acid. The raw materials of the preparation method of the tenofovir intermediate are easy to obtain, so cost control is facilitated; the target product is obtained through introducing relative configuration Z shape alkene and carrying out selective oxidation without using a large amount of a chiral compound, so the product selectivity is good, and the yield is high; and the method has the advantages of no special strict conditions, mild reaction conditions, and convenience in amplified production operation and industrial application promotion.
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