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KB-5246

NMR下載 COA and HPLC MSDS下載
names：
KB-5246
CAS號：
119474-55-4
MDL Number： MFCD00877050
MF(分子式)： C18H17ClFN3O4S MW(分子量)： 425.86
EINECS: Reaxys Number:
Pubchem ID:163306678 Brand:BIOFOUNT

KB-5246(119474-55-4,CTK0H7912)是一種四環(huán)喹諾酮，KB-5246具有抗菌活性。

貨品編碼	規(guī)格	純度	價格 (￥)	現(xiàn)價(￥)	特價(￥)	庫存描述	數(shù)量	總計 (￥)
YZM000412-1mg	1mg	>97%	￥ 14644.50	￥ 14644.50		2-3天	- +	￥ 0.00

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中文別名	KB-5246(119474-55-4);3H，8H-4-Oxa-1-thia-9b-氮雜環(huán)戊基[cd]苯-9-9-羧酸，6-氟-5-（4-甲基-1-哌嗪基）-8-氧代-，鹽酸鹽(1:1);CTK0H7912;
英文別名	KB-5246(119474-55-4);3H,8H-4-Oxa-1-thia-9b-azacyclopenta[cd]phenalene-9-carboxylicacid, 6-fluoro-5-(4-methyl-1-piperazinyl)-8-oxo-, hydrochloride (1:1);CTK0H7912;
CAS號	119474-55-4
Inchi	InChI=1S/C18H18FN3O4S.ClH/c1-21-2-4-22(5-3-21)15-14(19)8-6-10(23)13(18(24)25)17-11(8)12-9(20-27-17)7-26-16(12)15;/h11-12H,2-7H2,1H3,(H,24,25);1H
InchiKey	URZNPRNEDQSWGC-UHFFFAOYSA-N
分子式 Formula	C18H17ClFN3O4S
分子量 Molecular Weight	425.86
溶解度Solubility
性狀	Solid
儲藏條件 Storage conditions	室溫,請根據(jù)產(chǎn)品建議的存儲條件進(jìn)行存儲,Please store the product under the recommended condition sin the description.

KB-5246(119474-55-4,CTK0H7912)毒理性質(zhì)：

生物	測試類型	路線	報告劑量（標(biāo)準(zhǔn)化劑量）	影響	資源
mouse	LD50	intravenous	237mg/kg (237mg/kg)		Journal of Medicinal Chemistry. Vol. 35, Pg. 94, 1992.
mouse	LD50	oral	1231mg/kg (1231mg/kg)		Journal of Medicinal Chemistry. Vol. 35, Pg. 94, 1992.

KB-5246(119474-55-4,CTK0H7912)實驗注意事項：
1.實驗前需戴好防護眼鏡，穿戴防護服和口罩，佩戴手套，避免與皮膚接觸。
2.實驗過程中如遇到有毒或者刺激性物質(zhì)及有害物質(zhì)產(chǎn)生，必要時實驗操作需要手套箱內(nèi)完成以免對實驗人員造成傷害
3.實驗后產(chǎn)生的廢棄物需分類存儲，并交于專業(yè)生物廢氣物處理公司處理，以免造成環(huán)境污染Experimental considerations:
1. Wear protective glasses, protective clothing and masks, gloves, and avoid contact with the skin during the experiment.
2. The waste generated after the experiment needs to be stored separately, and handed over to a professional biological waste gas treatment company to avoid environmental pollution.

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產(chǎn)品說明	KB-5246(119474-55-4,CTK0H7912)是一種四環(huán)喹諾酮，KB-5246具有抗菌活性。
Introduction	KB-5246(119474-55-4,CTK0H7912)is a tetracyclic quinolone and displays antibacterial activities.
Application1
Application2
Application3

KB-5246(119474-55-4,CTK0H7912)藥理學(xué)：

1、KB-5246是四環(huán)喹諾酮，具有抗菌活性。90％的KB-5246分離株（MIC90s）對革蘭氏陽性菌如金黃色葡萄球菌（包括耐甲氧西林的金黃色葡萄球菌，表皮葡萄球菌，肺炎鏈球菌和化膿鏈球菌）的MIC為0.39μg / mL。KB5246抑制90％的分離株的大腸桿菌，肺炎克雷伯氏菌，產(chǎn)酸克雷伯菌在0.10微克/ mL的濃度或更少。當(dāng)添加MIC或更高濃度的KB-5246時，孵育24小時后未觀察到再生長。

2、KB-5246對肺炎鏈球菌 2132感染的50％有效劑量值為50.5 mg / kg體重。KB-5246對金黃色葡萄球菌史密斯，銅綠假單胞菌 GN11189和粘質(zhì)沙雷氏菌 GN7577感染的活性與氧氟沙星相當(dāng)，但大于諾氟沙星。

警示圖
危險性	warning
危險性警示	Not available
安全聲明	H303吞入可能有害+H313皮膚接觸可能有害+H2413吸入可能對身體有害
安全防護	P264處理后徹底清洗+P280戴防護手套/穿防護服/戴防護眼罩/戴防護面具+P305如果進(jìn)入眼睛+P351用水小心沖洗幾分鐘+P338取出隱形眼鏡（如果有）并且易于操作,繼續(xù)沖洗+P337如果眼睛刺激持續(xù)+P2393獲得醫(yī)療建議/護理
備注	實驗過程中防止吸入、食入，做好安全防護

Kotera Y, et al. In vitro and in vivo antibacterial activities of KB-5246, a new tetracyclic quinolone. Antimicrob Agents Chemother. 1989 Nov;33(11):1896-900.

KB-5246(119474-55-4,CTK0H7912)參考文獻(xiàn)：

1、In vitro and in vivo antibacterial activities of KB-5246, a new tetracyclic quinolone
Y Kotera 1, S Mitsuhashi

Abstract The in vitro and in vivo antibacterial activities of KB-5246, a tetracyclic quinolone, were compared with those of ciprofloxacin, ofloxacin, and norfloxacin. KB-5246 demonstrated a broad antibacterial spectrum. The in vitro activity of KB-5246 against gram-negative bacteria was higher than that of ofloxacin or norfloxacin and was comparable to that of ciprofloxacin. KB-5246 demonstrated the greatest activity against gram-positive bacteria of the four agents tested. Among Streptococcus pyogenes strains resistant to 1.56 micrograms of norfloxacin per ml, there were 26 strains susceptible to 0.2 micrograms of KB-5246 per ml. Similarly, among the Staphylococcus aureus and Staphylococcus epidermidis strains resistant to 3.13 micrograms of norfloxacin per ml, there were 23 S. aureus and 11 S. epidermidis strains susceptible to 0.39 micrograms of KB-5246 per ml. Among the Streptococcus pneumoniae and Enterococcus faecalis strains resistant to 12.5 micrograms of norfloxacin per ml, there were 5 S. pneumoniae and 10 E. faecalis strains susceptible to 0.39 micrograms of KB-5246 per ml. KB-5246 had bactericidal activity at the MIC. KB-5246 demonstrated excellent antibacterial activity against various systemic infections in mice. After oral administration, KB-5246 was as active as ofloxacin and about two times more active than norfloxacin.

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