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L-732531

NMR下載 COA and HPLC MSDS下載
names：
L-732531
CAS號(hào)：
148365-48-4
MDL Number：
MF(分子式)： C53H78N2O13 MW(分子量)： 951.2
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文別名	(1R,9S,12S,13R,14S,17R,18Z,21S,23S,24R,25S,27R)-17-ethyl-1,14-dihydroxy-12-[(1E)-1-[(1R,3R,4R)-4-{[1-(2-hydroxyethyl)-1H-indol-5-yl]oxy}-3-methoxycyclohexyl]prop-1-en-2-yl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0^{4,9}]octacos-18-ene-2,3,10,16-tetrone
英文別名	L-732531; L 732531; L732531;
CAS號(hào)	148365-48-4
Inchi	InChI=1S/C53H78N2O13/c1-10-37-24-31(2)23-32(3)25-46(64-8)49-47(65-9)27-34(5)53(62,68-49)50(59)51(60)55-19-12-11-13-41(55)52(61)67-48(35(6)42(57)30-43(37)58)33(4)26-36-14-17-44(45(28-36)63-7)66-39-15-16-40-38(29-39)18-20-54(40)21-22-56/h15-16,18,20,24,26,29,32,34-37,41-42,44-49,56-57,62H,10-14,17,19,21-23,25,27-28,30H2,1-9H3/b31-24+,33-26+/t32-,34+,35+,36-,37+,41-,42-,44+,45+,46-,47-,48+,49+,53+/m0/s1
InchiKey	UTOJCEZANIVKJJ-IUQQQLKSSA-N
分子式 Formula	C53H78N2O13
分子量 Molecular Weight	951.2
溶解度Solubility
性狀	Solid powder
儲(chǔ)藏條件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

產(chǎn)品說明	L-732531(CAS:148365-48-4):僅限應(yīng)用于工業(yè)或者科學(xué)研究過程中非醫(yī)療目的，不應(yīng)用于人類或動(dòng)物的臨床診斷以及治過程療，該產(chǎn)品非藥用，非食用。
Introduction	L-732531 is a tacrolimus-related immunosuppressant with reduced toxicity.
Application1
Application2
Application3

警示圖
危險(xiǎn)性	Warning
危險(xiǎn)性警示
安全聲明
安全防護(hù)
備注

[1]Padilla PI, Chang MJ, Pacheco-Rodriguez G, Adamik R, Moss J, Vaughan M. Interaction of FK506-binding protein 13 with brefeldin A-inhibited guanine nucleotide-exchange protein 1 (BIG1): effects of FK506. Proc Natl Acad Sci U S A. 2003 Mar 4;100(5):2322-7. Epub 2003 Feb 26. PubMed PMID: 12606707; PubMed Central PMCID: PMC151339.

[2]Karanam BV, Miller RR, Colletti A, Montgomery T, Carey KD, Hawkins T, Tang YS, Lavin M, Stearns RA, Chiu SH, Vincent SH. Disposition of L-732,531, a potent immunosuppressant, in rats and baboons. Drug Metab Dispos. 1998 Oct;26(10):949-57. PubMed PMID: 9763399.

[3] Salowe SP, Hermes JD. Competitive and slow-binding inhibition of calcineurin by drug x immunophilin complexes. Arch Biochem Biophys. 1998 Jul 15;355(2):165-74. PubMed PMID: 9675023.

[4] Dumont FJ, Koprak S, Staruch MJ, Talento A, Koo G, DaSilva C, Sinclair PJ, Wong F, Woods J, Barker J, Pivnichny J, Singer I, Sigal NH, Williamson AR, Parsons WH, Wyvratt M. A tacrolimus-related immunosuppressant with reduced toxicity. Transplantation. 1998 Jan 15;65(1):18-26. PubMed PMID: 9448138.

[5] Peterson LB, Cryan JG, Rosa R, Martin MM, Wilusz MB, Sinclair PJ, Wong F, Parsons JN, O'Keefe SJ, Parsons WH, Wyvratt M, Sigal NH, Williamson AR, Wiederrecht GJ. A tacrolimus-related immunosuppressant with biochemical properties distinct from those of tacrolimus. Transplantation. 1998 Jan 15;65(1):10-8. PubMed PMID: 9448137.

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