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Luteoskyrin

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names：
(5aS,6S,13aR,14S,17R,18S,19R,20R)-1,4,7,9,12,15,17,20-octahydroxy-3,11-dimethyl-14-hydro-5H,6H-6,13a,5a,14-(epibutane[1,2,3,4]tetrayl)cycloocta[1,2-b5,6-b']dinaphthalene-5,8,13,16-tetraone
CAS號(hào)：
21884-44-6
MDL Number：
MF(分子式)： C30H22O12 MW(分子量)： 574.49
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文別名	Luteoskyrin
英文別名	Luteoskyrin; Flavomycelin;
CAS號(hào)	21884-44-6
Inchi	InChI=1S/C30H22O12/c1-5-3-7(31)9-11(19(5)33)27(41)29-13-14-24(38)17(29)26(40)16-22(36)10-8(32)4-6(2)20(34)12(10)28(42)30(14,16)18(23(13)37)25(39)15(29)21(9)35/h3-4,13-14,17-18,23-24,31-34,37-40H,1-2H3/t13-,14+,17-,18-,23+,24+,29-,30+/m0/s1
InchiKey	KXNUPFFSGSRABD-KCIWCSDFSA-N
分子式 Formula	C30H22O12
分子量 Molecular Weight	574.49
溶解度Solubility
性狀	Solid powder
儲(chǔ)藏條件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

產(chǎn)品說(shuō)明	Luteoskyrin(CAS:21884-44-6):僅限應(yīng)用于工業(yè)或者科學(xué)研究過(guò)程中非醫(yī)療目的，不應(yīng)用于人類(lèi)或動(dòng)物的臨床診斷以及治過(guò)程療，該產(chǎn)品非藥用，非食用。
Introduction	Luteoskyrin is a hepatotoxic and hepatocarcinogenic bisdihydroanthraquinone produced by Penicillium islandicum Sopp.
Application1
Application2
Application3

警示圖
危險(xiǎn)性	Warning
危險(xiǎn)性警示
安全聲明
安全防護(hù)
備注

[1]Masuda T, Ito J, Akuzawa S, Ishii K, Takagi H, Ueno Y. Hepatic accumulation and hepatotoxicity of luteoskyrin in mice. Toxicol Lett. 1992 Jun;61(1):9-20. PubMed PMID: 1609444.

[2]Tseng HH, Tseng TC. Effects of naled and dichlorvos on growth and production of Luteoskyrin byPenicillium islandicum. Mycotoxin Res. 1993 Mar;9(1):35-40. doi: 10.1007/BF03192230. PubMed PMID: 23606065.

[3] Ueno Y, Ishikawa I. Production of luteoskyrin, a hepatotoxic pigment, by Penicillium islandicum Sopp. Appl Microbiol. 1969 Sep;18(3):406-9. PubMed PMID: 5373676; PubMed Central PMCID: PMC377994.

[4] Ueno I, Sekijima M, Hoshino M, Ohya-Nishiguchi H, Ueno Y. Spin-trapping and direct EPR investigations on the hepatotoxic and hepatocarcinogenic actions of luteoskyrin, an anthraquinoid mycotoxin produced by Penicillium islandicum Sopp. Generations of superoxide anion and luteoskyrin semiquinone radical in the redox systems consisted of luteoskyrin and liver NADPH- or NADH-dependent reductases. Free Radic Res. 1995 Jul;23(1):41-50. PubMed PMID: 7647918.

[5] Ueno I. Sex and age differences in luteoskyrin hepatotoxicity. Ann Nutr Aliment. 1977;31(4-6):789-802. PubMed PMID: 566069.

6: Ueno I, Hoshino M, Maitani T, Kanegasaki S, Ueno Y. Luteoskyrin, an anthraquinoid hepatotoxin, and ascorbic acid generate hydroxyl radical in vitro in the presence of a trace amount of ferrous iron. Free Radic Res Commun. 1993;19 Suppl 1:S95-100. PubMed PMID: 8282236.7: Ghosh AC, Manmade A, Kobbe B, Townsend JM, Demain AL. Production of luteoskyrin and isolation of a new metabolite, pibasterol, from Penicillium islandicum Sopp. Appl Environ Microbiol. 1978 Mar;35(3):563-6. PubMed PMID: 565188; PubMed Central PMCID: PMC242880.8: Mizutani K, Kumagai S, Mochizuki N, Kitagawa Y, Sugita-Konishi Y. Determination of a yellow rice toxin, luteoskyrin, in rice by using liquid chromatography-tandem mass spectrometry with electrospray ionization. J Food Prot. 2009 Jun;72(6):1321-6. PubMed PMID: 19610349.9: Tseng HH, Tseng TC. Effects of butylated hydroxyanisole, butylated hydroxytoluene and tertiary butylhydroquinone on growth and luteoskyrin production byPenicillium islandicum. Mycopathologia. 1995;129(2):73-8. doi: 10.1007/BF01103463. PubMed PMID: 20878563.10: KITAGAWA I, SHIBATA S. Metabolic products of fungi. X. The structure of rubroskyrin and its relation to the structure of luteoskyrin. Pharm Bull. 1956 Aug;4(4):309-13. PubMed PMID: 13378957.1

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